Ecological and Health Risk Mediated by Micro(nano)plastics Aging Process: Perspectives and Challenges

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Aged micro(nano)plastics (MNPs) are normally the ultimate state of plastics in environment after aging. The changes physical and chemical characteristics aged MNPs significantly influence their environmental behavior by releasing additives, forming byproducts, adsorbing contaminants. However, a systematic review is lacking on effects ecological human health regarding increasing but scattered studies results. This Review first summarizes unique methods for quantifying aging degree. Then we focused potential impacts organisms, ecosystems, health, including "Trojan horse" under real conditions. Through combining meta-analysis analytic hierarchy process (AHP) model, demonstrated that, compared to virgin MNPs, would result biomass decrease oxidative stress increase organisms lead total N/P greenhouse gas emissions ecosystems while causing cell apoptosis, antioxidant system reaction, inflammation health. Within framework risk assessment, used quotient (RQ) physiologically based pharmacokinetic (PBK) models as examples illustrate importance considering degree data acquisition, model building, formula evaluation. Given risks our urgent call more understand hazards real-world environments.

Language: Английский

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In Vitro Toxicity and Modeling Reveal Nanoplastic Effects on Marine Bivalves

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 17228 - 17239

Published: June 15, 2024

Nanoplastics (NPs) represent a growing concern for global environmental health, particularly in marine ecosystems where they predominantly accumulate. The impact of NPs on benthic organisms, such as bivalves, raises critical questions regarding ecological integrity and food safety. Traditional methods assessing NP toxicity are often limited by their time-intensive nature ethical considerations. Herein, we explore the toxicological effects bivalve

Language: Английский

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Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Oct. 17, 2024

It has long been widely acknowledged that ultraviolet (UV) light is an environment risk factor can lead to cancer, particularly skin cancer. However, it worth noting UV radiation holds potential for cancer treatment as a relatively high-energy electromagnetic wave. With the help of nanomaterials, role caught increasing attention in treatment. In this review, we briefly summarized types UV-induced cancers, including malignant melanoma, squamous cell carcinoma, basal Merkel carcinoma. Importantly, discussed primary mechanisms underlying carcinogenesis, mutations by DNA damage, immunosuppression, inflammation and epigenetic alterations. Historically limited its shallow penetration depth, introduction nanomaterials dramatically transformed utilization The direct effect itself generally leads suppression growth initiation apoptosis ferroptosis. also be utilized activate photosensitizers reactive oxygen species (ROS) production, sensitize radiotherapy achieve controlled drug release. Finally, comprehensively weigh significant risks limitations associated with therapeutic use radiation. And contradictory exposure promoting inhibiting tumor discussed. This review provides clues clinical therapy well future study directions field. precise delivery control or wavelength dose effects are needed thorough understanding

Language: Английский

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Co-exposure of decabromodiphenyl ethane and polystyrene nanoplastics damages grass carp (Ctenopharyngodon idella) hepatocytes: Focus on the role of oxidative stress, ferroptosis, and inflammatory reaction

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 940, P. 173575 - 173575

Published: May 31, 2024

Language: Английский

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Micro/nano plastics in the urinary system: Pathways, mechanisms, and health risks

Environment International, Journal Year: 2024, Volume and Issue: 193, P. 109109 - 109109

Published: Nov. 1, 2024

Micro/Nano plastics (MNPs) pollutants are widespread in the environment, raising significant concerns about their biosafety. Emerging studies indicate that urinary system is a primary accumulation site for MNPs, leading to severe tissue and functional damage. This review aims summarize recent research on potential hazards MNPs may pose system, highlighting mechanisms of toxicity current state knowledge. Studies have shown enter human body through drinking water, food chain, inhalation, skin contact. They penetrate bloodstream via digestive, respiratory, systems, subsequently dispersing various organs, including system. The might induce cellular oxidative stress, inflammation, apoptosis, autophagy, "intestine-kidney axis", other possible toxic mechanisms. These processes could disrupt kidney metabolic functions promote fibrosis, thereby potentially increasing risk diseases. Despite ongoing research, understanding MNPs' impact remains limited. Therefore, this provides comprehensive overview highlights key challenges, outlines future directions. It offers theoretical basis development effective protective measures policies.

Language: Английский

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Machine Learning-Aided 3D Dynamic SERS Strategy for Physiological Mapping: Biotoxicity of Environmentally Dimensional Aged Nanoplastics and Corresponding Protein Corona Complexes

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(42), P. 16629 - 16638

Published: Oct. 9, 2024

Nanoplastics (NPs) are emerging pollutants that undergo inevitable aging in the environment, raising concerns about human exposure and health hazards. Research on cytotoxicity of various polymer types NPs, aged nanoplastics (aNPs), their interactions with proteins (aNPs-protein corona) is still nascent. Traditional detection methods often rely end point assays restricted temporal resolution analysis single or multiple biomarkers. Here, we propose a novel approach integrating 3D dynamic SERS strategy (DSS) machine learning to rapidly analyze cell fate death modes induced by aNPs, aNPs-protein corona complexes at molecular level. PS, PVC, PMMA, PC products from water environment were used prepare corresponding impact UV irradiation physicochemical properties was examined. DSS systematically maps changes cellular secretome caused these NPs. Machine effectively extracts information complex spectra, differentiating between biological samples. Results show prolonged increases sensitivity ferroptosis while protein aNPs significantly mitigates toxicity associated surface oxygen-containing functional groups, resulting reduced similarity signatures. technique analyzes overall metabolite profile level rather than individual This study first attempt compare biotoxicity diverse coronas levels hepatocytes, enhancing our understanding impacts

Language: Английский

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Unveiling ferroptosis: a new frontier in skin disease research

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 4, 2024

Ferroptosis, a form of regulated cell death distinct from apoptosis, necrosis, and autophagy, is increasingly recognized for its role in skin disease pathology. Characterized by iron accumulation lipid peroxidation, ferroptosis has been implicated the progression various conditions, including psoriasis, photosensitive dermatitis, melanoma. This review provides an in-depth analysis molecular mechanisms underlying compares cellular effects with other forms context health disease. We systematically examine five specific diseases, ichthyosis, polymorphous light eruption (PMLE), vitiligo, melanoma, detailing influence on pathogenesis progression. Moreover, we explore current clinical landscape ferroptosis-targeted therapies, discussing their potential managing treating diseases. Our aim to shed therapeutic modulating research practice.

Language: Английский

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