Photorheologic Silicone Composites with Adaptive Properties by Utilizing Light‐Degradable Organosilica Nanoparticles as Fillers DOI Creative Commons

Florian Klodwig,

Laura Finck,

Nina Ehlert

et al.

Advanced Materials Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Abstract Implementing inorganic filler particles is a powerful method for improving the mechanical properties of polymer composites. The physical are determined by interaction with polymer. Thus, factors like surface‐to‐volume ratio and surface modification important. Besides strategies influencing these prior filler, this approach applies post‐treatment composite. present publication focuses on bringing stimuli‐responsive to composite material changing chemical composition structure particles. Instead creating responsive polymer, concept use photo‐degradable organosilica nanoparticles that can change polymer/filler after it has been prepared. After synthesis nitrobenzyl ether containing investigation photochemical processes, preparation composites silicones described. Vinyl groups attached surfaces secure homogeneous distribution inside matrix. light‐induced decomposition, investigated. Other than expected, becomes stiffer, which explained an increase in area silica particles, accompanied emergence hydroxy interact polysiloxane.

Language: Английский

Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

4
Revolutionizing Drug Delivery: The Impact of Advanced Materials Science and Technology on Precision Medicine DOI Creative Commons
Mohamed El‐Tanani, Shakta Mani Satyam, Syed Arman Rabbani

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 375 - 375

Published: March 15, 2025

Recent progress in material science has led to the development of new drug delivery systems that go beyond conventional approaches and offer greater accuracy convenience application therapeutic agents. This review discusses evolutionary role nanocarriers, hydrogels, bioresponsive polymers enhanced release, target accuracy, bioavailability. Oncology, chronic disease management, vaccine are some applications explored this paper show how these materials improve results, counteract multidrug resistance, allow for sustained localized treatments. The also translational barriers bringing advanced into clinical setting, which include issues biocompatibility, scalability, regulatory approval. Methods overcome challenges surface modifications reduce immunogenicity, scalable production methods such as microfluidics, harmonization systems. In addition, convergence artificial intelligence (AI) machine learning (ML) is opening frontiers personalized medicine. These technologies predictive modeling real-time adjustments optimize needs individual patients. use can be applied rare underserved diseases; thus, strategies gene therapy, orphan drugs development, global distribution may hopes millions

Language: Английский

Citations

2
Biomimetic Trypsin-Responsive Structure-Bridged Mesoporous Organosilica Nanomedicine for Precise Treatment of Acute Pancreatitis DOI
Yanan Wang,

Deyao Qian,

Xinyuan Wang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(29), P. 19283 - 19302

Published: July 11, 2024

Developing strategies to target injured pancreatic acinar cells (PACs) in conjunction with primary pathophysiology-specific pharmacological therapy presents a challenge the management of acute pancreatitis (AP). We designed and synthesized trypsin-cleavable organosilica precursor bridged by arginine-based amide bonds, leveraging trypsin's ability selectively identify guanidino groups on arginine via Asp189 at active S1 pocket cleave carboxy-terminal (C-terminal) bond catalytic triads. The precursors were incorporated into framework mesoporous silica nanoparticles (MSNs) for encapsulating membrane-permeable Ca

Language: Английский

Citations

10
Recent Advances in Silica-Based Nanomaterials for Enhanced Tumor Imaging and Therapy DOI
Junjie Zhang, Zilu Liu, Zhijing Zhang

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7133 - 7169

Published: Nov. 4, 2024

Cancer remains a formidable challenge, inflicting profound physical, psychological, and financial burdens on patients. In this context, silica-based nanomaterials have garnered significant attention for their potential in tumor imaging therapy owing to exceptional properties, such as biocompatibility, customizable porosity, versatile functionalization capabilities. This review meticulously examines the latest advancements application of therapy. It underscores enhancing various cancer modalities, including fluorescence imaging, magnetic resonance computed tomography, positron emission ultrasound multimodal approaches. Moreover, delves into therapeutic efficacy chemotherapy, radiotherapy, phototherapy, immunotherapy, gas therapy, sonodynamic chemodynamic starvation gene Critical evaluations biosafety profiles degradation pathways these within biological environments are also presented. By discussing current challenges prospects, aims provide nuanced perspective clinical translation nanomaterials, thereby highlighting promise revolutionizing diagnostics, enabling real-time monitoring responses, advancing personalized medicine.

Language: Английский

Citations

4
Tunable Stimuli-Responsive Module Based on α-Hydroxymethyl-α,β-Unsaturated Carbonyl Scaffold DOI

Rongfeng Shen,

Baoxin Zhang, Lanning Zhao

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The α-hydroxymethyl-α,β-unsaturated carbonyl (HMUC) scaffold represents a valuable framework for constructing nucleophile-responsive materials.

Language: Английский

Citations

0
Harnessing stimuli-responsive NO nanomaterials for advanced multi-disease therapy DOI
Junjie Zhang, Haiyang Guo, Longguang Tang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216540 - 216540

Published: Feb. 27, 2025

Language: Английский

Citations

0
A Facile Approach To Develop Ion Pair Micelles Satellited Freshly Derived Neutrophils For Targeted Tumor Therapy DOI Open Access
Garima Sharma,

Kwanjira Wangpimool,

Jomon George Joy

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Immune cells show enormous potential for targeted nanoparticle delivery due to their intrinsic tumor-homing skills. However, the immune can internalize nanoparticles, leading cellular functional impairments, degradation of and delayed release drugs from cells. To address these issues, this study introduces an approach synthesis freshly derived neutrophils (NUs)-based nanocarriers system where NUs are surfaced by dialdehyde alginate-coated self-assembled micelles loaded with mitoxantrone (MIT) indocyanine green (ICG) (i.e., dA(MI@IPM)s) stimuli-responsive tumor-targeted therapy. Here, dA(MI@IPM)s not internalized NUs, but they anchored on membrane via distearoylphosphatidylethanolamine-polyethylene glycol-polyethylenimine anchors. Owing natural recruitment ability tumor microenvironment, NUs-anchored accumulation is higher at site than free dA(MI@IPM)s, readily detach get in The disassembles inside cancer upon near-infrared irradiation photosensitizing effect ICG, releasing MIT significantly inhibiting growth. This simple fast prepare, opening up exciting possibilities personalized treatment using patient's autologous NUs.

Language: Английский

Citations

0
Nanomedicine with simple structure for programmable heat-shock protein inhibition and sensitized synergistic therapy DOI Creative Commons
Hanji Huang, Yan Sun, Jinhong Cai

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161307 - 161307

Published: March 1, 2025

Language: Английский

Citations

0
Photorheologic silicone composites with adaptive properties by utilizing light-degradable organosilica nanoparticles as fillers DOI Creative Commons

Florian Klodwig,

Laura Finck,

Nina Ehlert

et al.

Published: June 12, 2024

Implementing inorganic filler particles is a powerful method for improving the mechanical properties of formed composites. Fillers made silicon dioxides can be found in countless polymeric materials. Because interaction silica with polymer determines physical properties, factors like surface-to-volume ratio (controlled via particle size) and surface modification are important. Systems which just physically dispersed behave significantly differently to those covalent anchoring fillers. Another possible functionality we focus on current publication that they bring stimuli-responsive system. Our concept photo-degradable organosilica nanoparticles change polymer/filler composite after it has been prepared. huge applicability polysiloxanes ranging from building materials medicine, silicones were selected as center interest paper. After synthesis containing bridging nitrobenzyl ether, investigation photochemical decomposition processes, preparation composites described. It shown vinyl groups attached surfaces crucial securing homogeneous distribution inside matrix. Finally, light-induced executed investigated by dynamic analysis. Other than expected, material becomes stiffer. This effect explained coupled increase accompanied emergence hydroxy interact polysiloxane backbone.

Language: Английский

Citations

1
Insights into Tumor Size-Dependent Nanoparticle Accumulation Using Deformed Organosilica Nanoprobes DOI
Yuchen Miao,

Hengda Du,

Wenqing Zhang

et al.

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Deformed organosilica nanoprobes (CDPF) exhibit enhanced accumulation within larger tumors, highlighting the pivotal role of tumor microenvironment in optimization nanoparticle-based therapeutic strategies.

Language: Английский

Citations

1