A general strategy towards activatable nanophotosensitizer for phototoxicity-free photodynamic therapy DOI

Guozhu Tan,

Q.P. Zhong, Jibin Zhang

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 15(3), P. 943 - 964

Published: Dec. 2, 2024

Language: Английский

Stem cells vesicles-loaded type I pro-photosensitizer for synergetic oxygen-independent phototheranostics and microenvironment regulation in infected diabetic wounds DOI
Qin Zeng, Ying Zhang, Judun Zheng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159239 - 159239

Published: Jan. 10, 2025

Language: Английский

Citations

9
Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment DOI Creative Commons
Mengyao Yang, Xin Wang,

Mengke Peng

et al.

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Language: Английский

Citations

2
A new era of cancer phototherapy: mechanisms and applications DOI
Yuanwei Wang, Ke Ma,

Miaomiao Kang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The past decades have witnessed great strides in phototherapy as an experimental option or regulation-approved treatment numerous cancer indications.

Language: Английский

Citations

13
Minimized background tumor imaging through self-assembled disulfide dicyanine nanoparticles DOI
Liming Hu, Peng Wang, Lei Wan

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 334, P. 125908 - 125908

Published: Feb. 16, 2025

Language: Английский

Citations

1
Challenging and new opportunities for prodrug technology DOI
Helin Li,

Xuelian Shen,

Yu Chu

et al.

Investigational New Drugs, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

0
A Microneedle Patch Delivers Mitochondria‐ and Lysosomes‐ Dual Targeting Prodrug‐Like Photosensitizers with Regulated Photoactivity for Precise Photodynamic Therapy DOI Open Access
Zheng Liu,

Zhimin Tang,

Ying Yin

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Antitumor photodynamic therapy (PDT) faces huge challenges as selectivity and phototoxic damage, requiring delivery photosensitizers (PSs) to specifically accumulate in tumors even organelle, avoid the damage during delivery. Herein, a microneedle patch (AIE-mito-TPP@MN) containing mitochondria- lysosomes- dual targeting prodrug-like PSs (AIE-mito-TPP/AlPcSNa4) that is self-assembled by mitochondria-targeted aggregation-induced-emission molecule (AIE-mito-TPP) lysosome-targeted aluminum phthalocyanine tetrasulfonate (AlPcSNa4), developed achieve cancer-cell-organelle-specific for precise PDT with high low damage. AIE-mito-TPP/AlPcSNa4 displays activity via regulated photoactivity reduce caused "always on" PSs. Meanwhile, AIE-mito-TPP/AlPcSNa4@MN can insert into epidermis rapid tumor lesion, enhance selective accumulation cells. The higher lysosomal acidity cells facilitates disassembly promotes targeting. Under light irradiation, impairs mitochondrial function induce deeper apoptosis at dose (≈6 µg), presenting greater therapeutic efficacy than AIE-mito-TPP@MN, AlPcSNa4@MN, or intravenous injection. Moreover, presents good biocompatibility lower normal cells, well of Therefore, organelle-targeting possesses great potential selectivity.

Language: Английский

Citations

0
GSH-responsive nanomedicine for disease smart imaging and therapy DOI

Zi Fu,

Di Zhou, Zeyang Liu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216554 - 216554

Published: Feb. 27, 2025

Language: Английский

Citations

0
Controlling stimulus sensitivity by tailoring nanoparticle core hydrophobicity DOI Creative Commons
Xiao Zhang, Bowen Zhao, Shiwei Fu

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This study introduces a novel and efficient approach for constructing stimulus-responsive polycarbonates with tunable stimulus sensitivity by tailoring nanoparticle core hydrophobicity.

Language: Английский

Citations

0
Switchable Nanophotosensitizers as Pyroptosis Inducers for Targeted Boosting of Antitumor Photoimmunotherapy DOI

Xiaoxi Zhao,

Q.P. Zhong,

Naibijiang Abudouaini

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Photodynamic therapy (PDT) has emerged as a promising modality for cancer treatment, but its clinical application is constrained by unexpected phototoxicity arising from nonspecific photosensitizer activation and their "always-on" nature. Herein, we developed switchable nanophotosensitizer, poly(cation-π) nanoparticles (NP), which achieves supramolecular assembly through cation-π interactions. By coupling choline cationic moieties with aromatic photosensitizers (ZnPc), the polymer facilitates self-assembly driven interactions NP engineering. Surprisingly, photoactivity of ZnPc was completely quenched upon complexation via interactions, thereby significantly avoiding skin phototoxicity. Upon targeting tumor cells, undergoes GSH-responsive degradation process that weakens leading to spontaneous restoration amplifying immunogenic pyroptosis. In vivo studies demonstrated achieved high inhibition rate 84% while effectively This work provides novel perspective enhancing safety efficacy PDT-based treatment.

Language: Английский

Citations

0
Development and Application of Organic Sonosensitizers in Cancer Therapy DOI Creative Commons
Yuhan Ding,

Yuchen Yang,

Ömer Aras

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.

Language: Английский

Citations

0