Photocrosslinkable Biomaterials for 3D Bioprinting: Mechanisms, Recent Advances, and Future Prospects

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12567 - 12567

Published: Nov. 22, 2024

Constructing scaffolds with the desired structures and functions is one of main goals tissue engineering. Three-dimensional (3D) bioprinting a promising technology that enables personalized fabrication devices regulated biological mechanical characteristics similar to natural tissues/organs. To date, 3D has been widely explored for biomedical applications like engineering, drug delivery, screening, in vitro disease model construction. Among different bioinks, photocrosslinkable bioinks have emerged as powerful choice advanced devices, fast crosslinking speed, high resolution, great print fidelity. The biomaterials used light-based printing play pivotal role functional constructs. Herein, this review outlines general approaches related biomaterials, including extrusion-based printing, inkjet stereolithography laser-assisted printing. Further, mechanisms, advantages, limitations photopolymerization photoinitiators are discussed. Next, recent advances synthetic highlighted. Finally, challenges future perspectives envisaged.

Language: Английский

Femtosecond‐Laser Preparation of Hydrogel with Micro/Nano‐Structures and their Biomedical Applications

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Hydrogels with micro/nano‐structures precisely prepared by femtosecond‐laser processing technology are biomaterials that mimic the natural extracellular matrix and can achieve precise regulation of biological properties, such as cell behavior structural–mechanical properties. They also play a crucial role in biomedical fields regenerative medicine, bionanostructural construction, drug transport, particle manipulation. This study summarizes central nonlinear absorption property femtosecond lasers preparation hydrogel micro/nano‐structures. Based on electron‐dynamics model electron‐density flood theory, two main types laser‐processed hydrogel, additive subtractive manufacturing, discussed depth. The modification mechanisms photon–electron energy‐field conversion, multiphoton effect, bubble‐driven bio‐link molding analyzed. Additionally, stimulus‐response diversification functional biomimicry properties structural hydrogels under influences different laser action modes composition ratios investigated for their applications, microactuators, delivery, microscaffolds, vitro simulation vascular networks. On this basis, advantages limitations current summarized reasonable prediction future research law is made.

Language: Английский