Synthesis and Characterization of Photocurable Difunctional Monomers for Medical Applications DOI Open Access
Gökhan Demirci, Agata Goszczyńska, Martyna Sokołowska

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3584 - 3584

Published: Dec. 21, 2024

Photocurable materials offer a rapid transition from liquid to solid state, and have recently received great interest in the medical field. However, while dental resins are very popular, only few been developed for soft tissue repair. This study aims synthesize difunctional methacrylate monomer using dibutyltin dilaurate which is suitable photocuring of materials. These were compared with PhotoBioCure® (Szczecin, Poland) material similar molecular weight, Mn ~7000 g/mol on average. Infrared spectroscopy was used monitor two-step synthesis catalyzed dilaurate, spectroscopic chromatographic methods determine chemical structure weight monomers. Photopolymerization kinetics under varying light intensities explored nitrogen atmosphere representative The mechanical testing resulting elastomeric films confirmed tensile strength modulus values consistent parameters range 3–4 MPa. 3D printability macromonomers also assessed. Additionally, cytotoxicity assessments cultured cells showed high cell viability (97%) all new Overall, we demonstrate that monomers converted flexible solids during photopolymerization show potential biomedical applications.

Language: Английский

Bioprinting and Intellectual Property: Challenges, Opportunities, and the Road Ahead DOI Creative Commons
Antreas Kantaros, Theodore Ganetsos, Florian Ion Tiberiu Petrescu

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(1), P. 76 - 76

Published: Jan. 15, 2025

Bioprinting, an innovative combination of biotechnology and additive manufacturing, has emerged as a transformative technology in healthcare, enabling the fabrication functional tissues, organs, patient-specific implants. The implementation aforementioned, however, introduces unique intellectual property (IP) challenges that extend beyond conventional biotechnology. study explores three critical areas concern: IP protection for bioprinting hardware bioinks, ownership ethical management digital files derived from biological data, implications commercializing bioprinted tissues organs. Employing multidisciplinary approach, paper analyzes existing frameworks, highlights their limitations when applied to bioprinting, examines dilemmas, such human commodification innovations. Findings suggest current laws inadequately address complexities particularly managing intersection proprietary technologies considerations. underscores need adaptive legal frameworks balance innovation with equitable access sustainability. Recommendations include development tailored policies enhanced international collaboration harmonize protections across jurisdictions. This work aims provide comprehensive foundation stakeholders navigate rapidly evolving landscape IP.

Language: Английский

Citations

9
Development of an alginate-based bioink with enhanced hemostatic and antibacterial properties DOI
Mengde Zhang,

Linhao Hou,

Wei Song

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140549 - 140549

Published: Jan. 31, 2025

Language: Английский

Citations

0
Light-Activated Decellularized Extracellular Matrix-Based Bioinks for Enhanced Mechanical Integrity DOI Creative Commons
Minji Kim, Dayoon Kang, Hohyeon Han

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101859 - 101859

Published: May 1, 2025

Language: Английский

Citations

0
Synthesis and Characterization of Photocurable Difunctional Monomers for Medical Applications DOI Open Access
Gökhan Demirci, Agata Goszczyńska, Martyna Sokołowska

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3584 - 3584

Published: Dec. 21, 2024

Photocurable materials offer a rapid transition from liquid to solid state, and have recently received great interest in the medical field. However, while dental resins are very popular, only few been developed for soft tissue repair. This study aims synthesize difunctional methacrylate monomer using dibutyltin dilaurate which is suitable photocuring of materials. These were compared with PhotoBioCure® (Szczecin, Poland) material similar molecular weight, Mn ~7000 g/mol on average. Infrared spectroscopy was used monitor two-step synthesis catalyzed dilaurate, spectroscopic chromatographic methods determine chemical structure weight monomers. Photopolymerization kinetics under varying light intensities explored nitrogen atmosphere representative The mechanical testing resulting elastomeric films confirmed tensile strength modulus values consistent parameters range 3–4 MPa. 3D printability macromonomers also assessed. Additionally, cytotoxicity assessments cultured cells showed high cell viability (97%) all new Overall, we demonstrate that monomers converted flexible solids during photopolymerization show potential biomedical applications.

Language: Английский

Citations

0