Rational Design of Inner Ear Drug Delivery Systems DOI Creative Commons

Xiayidan Maimaitikelimu,

Zhihong Xuan,

Haoyu Ren

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract The number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well a huge social burden. Among these caused by inner ear lesions accounts for large proportion. Therefore, treatment the important. Inner drug delivery systems, which can reduce side effects systemic administration delivering drugs directly ear, are important in sensorineural loss. Here, development systems focused, including complex physiological structure that they face, types delivered, routes administration, forms carrier platforms. Recent studies this process presented it concluded summary outlook on problems faced possible solutions.

Language: Английский

Light-Driven Microrobots for Targeted Drug Delivery DOI
Qilong Cheng,

Xingqi Lu,

Yunhao Tai

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(9), P. 5562 - 5594

Published: Aug. 15, 2024

As a new micromanipulation tool with the advantages of small size, flexible movement and easy manipulation, light-driven microrobots have wide range prospects in biomedical fields such as drug targeting cell manipulation. Recently, been controlled various ways, light field has become research hotspot by its noncontact precise localization, fast response, biocompatibility. It utilizes force or deformation generated to precisely control microrobot, combines release technology realize targeted application. Therefore, this paper provides an overview provide ideas for manipulation microrobots. Here, briefly categorizes driving mechanisms materials microrobots, which mainly include photothermal, photochemical, biological. Then, typical designs different strategies multiple physical are summarized. Finally, applications bioimaging presented well future demonstrated.

Language: Английский

Citations

6
Age-related hearing loss in older adults: etiology and rehabilitation strategies DOI Creative Commons

Qinzhi Zheng,

Zhuo Xu,

Nan Li

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Oct. 1, 2024

Age-related hearing loss (ARHL) is a prevalent sensory organ disorder among elderly individuals that significantly impacts their cognitive function, psychological well-being, and ability to perform activities of daily living. As the population ages, number ARHL patients increasing. However, Audiological rehabilitation (AR) status not promising. In recent years, there has been an increasing focus on health individuals, significant progress made in researching various age-related disorders. unified definition terms etiology treatment still lacking. This study aims provide reference for future research development AR strategies by reviewing classification, etiology, ARHL.

Language: Английский

Citations

4
Multifunctional nanocomposite-driven microneedles enabling bacteria capturing, detecting, and killing for precision treatment of acne with varying severities DOI
Huaan Li, Hanqi Li,

Yuwei Kou

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163339 - 163339

Published: May 1, 2025

Language: Английский

Citations

0
Rational Design of Inner Ear Drug Delivery Systems DOI Creative Commons

Xiayidan Maimaitikelimu,

Zhihong Xuan,

Haoyu Ren

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract The number of people with hearing loss disorders is enormous, causing great physical and mental stress to patients, as well a huge social burden. Among these caused by inner ear lesions accounts for large proportion. Therefore, treatment the important. Inner drug delivery systems, which can reduce side effects systemic administration delivering drugs directly ear, are important in sensorineural loss. Here, development systems focused, including complex physiological structure that they face, types delivered, routes administration, forms carrier platforms. Recent studies this process presented it concluded summary outlook on problems faced possible solutions.

Language: Английский

Citations

0