Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110771 - 110771
Published: Dec. 1, 2024
Language: Английский
Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Abstract The extracellular matrix (ECM) serves not only as a structural scaffold but also an active regulator of cancer progression, profoundly influencing tumor behaviour and the microenvironment (TME). This review focuses into pivotal role ECM alterations in facilitating metastasis explores therapeutic strategies aimed at counteracting these changes. We analyse targeted interventions against collagen, including approaches to inhibit its biosynthesis disrupt associated signalling pathways critical for architecture cell migration. Additionally, therapies addressing hyaluronan are reviewed, highlighting methods suppress synthesis enzymatic degrade it, thereby mitigating tumor‐promoting effects. discussion extends innovative modulating stiffness, focusing on roles cancer‐associated fibroblasts lysyl oxidases, which key contributors remodelling mechanical signalling. By strategically modifying components, aim enhance efficacy existing treatments, tackle resistance mechanisms, achieve more durable outcomes. Insights from recent studies clinical trials highlight promise overcoming treatment improving patient Advancing our understanding biology leads development effective therapies.
Language: Английский
Citations
3
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 375 - 375
Published: March 15, 2025
Recent progress in material science has led to the development of new drug delivery systems that go beyond conventional approaches and offer greater accuracy convenience application therapeutic agents. This review discusses evolutionary role nanocarriers, hydrogels, bioresponsive polymers enhanced release, target accuracy, bioavailability. Oncology, chronic disease management, vaccine are some applications explored this paper show how these materials improve results, counteract multidrug resistance, allow for sustained localized treatments. The also translational barriers bringing advanced into clinical setting, which include issues biocompatibility, scalability, regulatory approval. Methods overcome challenges surface modifications reduce immunogenicity, scalable production methods such as microfluidics, harmonization systems. In addition, convergence artificial intelligence (AI) machine learning (ML) is opening frontiers personalized medicine. These technologies predictive modeling real-time adjustments optimize needs individual patients. use can be applied rare underserved diseases; thus, strategies gene therapy, orphan drugs development, global distribution may hopes millions
Language: Английский
Citations
2
Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(8)
Published: May 31, 2024
Immune dysregulation is a pivotal factor in the onset and progression of various diseases. In cancer, immune system's inability to discern eliminate abnormal cells leads uncontrolled tumor growth. When faced with resilient pathogens or harmful toxins, system encounters challenges clearance neutralization. Achieving delicate balance pro‐inflammatory anti‐inflammatory signals essential managing range disorders Like other biomedical research domains, nanotechnology has provided innovative approaches for rebalancing host immunity. Among plethora nanotechnology‐based interventions, concept cell membrane‐coated nanoparticles holds significant potential immunomodulatory applications owing their biomimetic properties that allow precise interaction compromised system. This review thoroughly examines novel nanosystems modulation. The exploration covers crucial elements, including origins characteristics membranes, methods employed procurement coating, physicochemical/biological characterization techniques, enhancement therapeutic efficacy via functionalization. Subsequently, case studies‐based analysis utilizing these bioinspired tackling different conditions caused by disturbance been comprehensively discussed.
Language: Английский
Citations
12
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 131802 - 131802
Published: April 25, 2024
Language: Английский
Citations
8
Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1924 - 1924
Published: Nov. 20, 2024
Identifying definitive biomarkers that predict clinical response and resistance to immunotherapy remains a critical challenge. One emerging factor is extracellular acidosis in the tumor microenvironment (TME), which significantly impairs immune cell function contributes failure. However, acidic conditions TME disrupt interaction between cancer cells, driving tumor-infiltrating T cells NK into an inactivated, anergic state. Simultaneously, promotes recruitment activation of immunosuppressive such as myeloid-derived suppressor regulatory (Tregs). Notably, acidity enhances exosome release from Tregs, further amplifying immunosuppression. Tumor thus acts "protective shield," neutralizing anti-tumor responses transforming pro-tumor allies. Therefore, targeting lactate metabolism has emerged promising strategy overcome this barrier, with approaches including buffer agents neutralize pH inhibitors block production or transport, thereby restoring efficacy TME. Recent discoveries have identified genes involved (pHe) regulation, presenting new therapeutic targets. Moreover, ongoing research aims elucidate molecular mechanisms acidification develop treatments modulate levels enhance outcomes. Additionally, future studies are crucial validate safety pHe-targeted therapies patients. Thus, review explores regulation pHe its potential role improving immunotherapy.
Language: Английский
Citations
8
Molecules, Journal Year: 2024, Volume and Issue: 29(13), P. 3131 - 3131
Published: July 1, 2024
The delivery of therapeutic agents faces significant hurdles posed by the endo-lysosomal pathway, a bottleneck that hampers clinical effectiveness. This comprehensive review addresses urgent need to enhance cellular mechanisms overcome these obstacles. It focuses on potential smart nanomaterials, delving into their unique characteristics and in detail. Special attention is given ability strategically evade endosomal entrapment, thereby enhancing efficacy. manuscript thoroughly examines assays crucial for understanding escape uptake dynamics. By analyzing various assessment methods, we offer nuanced insights investigative approaches' multifaceted aspects. We meticulously analyze use nanocarriers, exploring diverse such as pore formation, proton sponge effects, membrane destabilization, photochemical disruption, strategic agents. Each mechanism's effectiveness application mitigating entrapment are scrutinized. paper provides critical overview current landscape, emphasizing advanced systems navigate complexities uptake. Importantly, it underscores transformative role nanomaterials revolutionizing strategies, leading paradigm shift towards improved outcomes.
Language: Английский
Citations
6
Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(8), P. 104060 - 104060
Published: June 12, 2024
The application of nanotechnology has significantly advanced the development novel platforms that enhance disease treatment and diagnosis. A key innovation in this field is creation antitoxin nanoparticles (ATNs), designed to address toxin exposure. These precision-engineered nanosystems have unique physicochemical properties selective binding capabilities, allowing them effectively capture neutralize toxins from various biological, chemical, environmental sources. In review, we thoroughly examine their therapeutic diagnostic potential for managing toxin-related challenges. We also explore recent advancements offer critical insights into design clinical implementation ATNs.
Language: Английский
Citations
4
Frontiers in Biomaterials Science, Journal Year: 2025, Volume and Issue: 4
Published: Feb. 12, 2025
Immunotherapy has emerged as a powerful approach in treating various diseases, yet its success often hinges on the efficacy of adjuvants, agents that boost immune responses to therapeutic targets. Traditional adjuvants have offered foundational support but may fall short achieving specificity and potency required for advanced therapies. This review highlights new generation poised address these limitations. We explore range innovative agents, including non-inflammatory nucleic acid bacterial derivatives, synthetic molecules, which are redefining role immunotherapy. These emerging hold promise enhancing while tailoring therapies specific disease contexts, from cancer infectious diseases. By examining applications potential this aims provide comprehensive understanding how they can advance immunotherapy levels precision. Through development novel stands achieve more targeted sustained impacts, paving way improved outcomes patient care.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Cancer nanovaccines represent a promising approach to cancer immunotherapy, offering advantages such as safety, efficacy, and personalization. However, challenges complex compositions, limited structural control, significant side effects impede their clinical application. In this study, we developed strategy for preparing through the co-assembly of well-defined single-component organic small molecules with antigens. By carefully adjusting length alkyl chains within molecules, achieved precise control over assembly behavior final optimized antigen-loading efficiency. After elucidating relationship between molecular structure resulting nanovaccine assemblies, identified molecule TCSVP, which serves both potent adjuvant an effective antigen carrier. Interestingly, TCSVP efficiently activates STING pathway in dendritic cells. Furthermore, three preventive tumor models, complete resistance rate ≥ 50% against inoculation established robust immune memory lasting up 135 days. Additionally, compared commercially available Freund's adjuvant, demonstrated superior activation while exhibiting negligible immune-related inflammatory effects, indicating favorable safety efficacy profile. This work not only highlights potential development advanced but also provides valuable insights design molecule-based self-adjuvanting nanovaccines.
Language: Английский
Citations
0
Nanomaterials, Journal Year: 2025, Volume and Issue: 15(2), P. 122 - 122
Published: Jan. 16, 2025
Nano-oncologic vaccines represent a groundbreaking approach in the field of cancer immunotherapy, leveraging unique advantages nanotechnology to enhance effectiveness and specificity treatments. These utilize nanoscale carriers deliver tumor-associated antigens immunostimulatory adjuvants, facilitating targeted immune activation promoting robust antitumor responses. By improving antigen presentation localizing within tumor microenvironment, nano-oncologic can significantly increase efficacy particularly when combined with other treatment modalities. This review highlights mechanisms through which operate, their potential overcome existing limitations treatment, ongoing advancements design. Additionally, it discusses delivery approach, such as EPR effects, pH response, ultrasonic magnetic response. The combination therapy effects photothermal therapy, radiotherapy, or checkpoint inhibitors are also discussed. Overall, hold great promise for changing landscape advancing personalized medicine, paving way more effective therapeutic strategies tailored individual patient needs.
Language: Английский
Citations
0