Thoracic Cancer,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 27, 2024
ABSTRACT
Background
Existing
studies
have
shown
that
transferrin
receptor
(TfR)
is
highly
expressed
on
the
surface
of
lung
cancer
cells,
and
nanoparticles
(NPs)
been
widely
used
as
delivery
vehicles.
The
aim
this
study
was
to
investigate
effect
targeted
Fe
3
O
4
NPs
modified
with
(Tf)
compared
photothermal
treatment
for
cancer.
Methods
morphology
properties
Fe3O4
Tf
were
tested
by
internal
morphological
characterization
experiments
including
transmission
electron
microscopy,
particle
size
meter
infrared
spectrometer
other
experiments.
materials
investigated
cell
proliferation
apoptosis
experiments,
western
blot
experiment
detect
yes‐associated
protein
1(YAP1)
expression
changes
after
delivering
miR‐15a‐5p.
In
addition,
animal
models
constructed
further
explore
targeting
material.
Results
results
demonstrated
nanomaterial
has
good
stability
properties.
Meanwhile,
we
also
discovered
miR‐15a‐5p
carried
can
inhibit
growth
its
entry
cells.
became
more
evident
when
nanomaterials
assisted
laser
therapy,
verified
in
vivo
vitro
terms
related
mechanism,
inhibited
YAP1
expression,
which
affected
apoptosis.
Conclusion
study,
delivered
combination
therapy
future
research,
synergy
will
provide
a
theoretical
basis
treatment.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 15, 2025
Biometallic
ions
play
a
crucial
role
in
regulating
the
immune
system.
In
recent
years,
cancer
immunotherapy
has
become
breakthrough
treatment,
achieving
good
efficacy
wide
range
of
cancers
with
its
specificity
and
durability
advantages.
However,
existing
therapies
still
face
challenges,
such
as
tolerance
escape.
(e.g.
zinc,
copper,
magnesium,
manganese,
etc.)
can
assist
enhancing
through
activation
cells,
enhancement
tumor
antigen
presentation,
improvement
microenvironment.
addition,
biometallic
derivatives
directly
inhibit
cell
progression
offer
possibility
effectively
overcoming
limitations
current
by
promoting
responses
reducing
immunosuppressive
signals.
This
review
explores
potential
application
prospects
immunotherapy,
providing
new
ideas
for
future
clinical
metal
part
helping
to
guide
development
more
effective
safe
therapeutic
regimens.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
Current
immunotherapies
such
as
immune
checkpoint
blockades
(ICBs)
have
revolutionized
oncotherapy
regime;
however,
their
responsiveness
and
efficiencies
among
patients
with
head
neck
squamous
cell
carcinoma
(HNSCC)
remain
quite
limited.
The
existence
of
therapeutic-refractory
cancer
stem
cells
(CSCs)
inadequate
activation
the
cyclic
guanosine
monophosphate-adenosine
monophosphate
synthase/interferon
gene
stimulator
(cGAS/STING)
signaling
pathway
greatly
contribute
to
evasion
immunotherapeutic
resistance.
Herein,
we
sought
develop
a
nanocomplex
for
HNSCC
therapy
by
simultaneous
CSCs
eradication
STING
activation.
PTC209/MnO2@BSA
(bovine
serum
albumin)
nanoparticles
(PMB
NPs)
synthesized
via
facile
green
process
are
reported,
wherein
released
manganese
(Mn)
ions
under
acidic
tumor
microenvironment
significantly
enhance
cGAS-STING
signals
facilitate
dendritic
maturation
unleash
T-cell-mediated
response.
Meanwhile,
PTC209
from
PMB
NPs
targets
BMI1+
suppress
stemness
epithelial-mesenchymal
transition
(EMT)
elicits
apoptosis
further
potentiate
Mn-based
metalloimmunotherapy.
Both
in
vitro
vivo
experiments
elucidate
that
function
designed,
exerting
powerful
chemotherapeutic
impacts
impede
growth
metastasis
well
bolster
anti-PD-1-based
ICB.
Collectively,
our
findings
provide
promising
therapeutic
strategy
against
combinational
elimination
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
During
the
treatment
of
solid
tumors,
local
therapeutic
approaches
carry
risk
incomplete
radical
cure,
which
may
lead
to
rapid
tumor
growth.
Incomplete
microwave
ablation
(iMWA)
can
induce
tumors
exhibit
highly
invasive
and
uncontrollable
growth,
is
related
immunosuppressive
microenvironment.
A
multifunctional
bimetallic
Ca/Zn
nanoagonist
(PZH/Zn@CaNA)
with
a
biomimetic
liposome-modified
surface
tissues
after
iMWA
developed.
In
response
acidic
microenvironment,
released
traditional
Chinese
medicine
preparation
Pien
Tze
Huang
(PZH)
reduced
protein
expressions
JAK2-STAT3
signaling
pathway,
thereby
slowing
down
proliferation
growth
hepatocellular
carcinoma
(HCC).
Furthermore,
ions
Ca2⁺
Zn2⁺
cascade
enhance
killing
effect
oxidative
stress,
generating
substantial
amounts
reactive
oxygen
species.
This
process
induces
pyroptosis
releases
significant
quantities
damage
associated
molecular
patterns,
triggering
immune
activation
mechanisms
STING
pathway
that
reshape
HCC
microenvironment
resulting
from
iMWA.
strategy
markedly
differs
previous
chemoimmunotherapies,
not
only
effectively
addressed
problem
conventional
drugs
showing
heterogeneous
distribution
in
regions,
but
also
verified
critical
role
played
by
PZH/Zn@CaNA
inhibiting
iMWA-induced
regulating
stress
remodeling
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101649 - 101649
Published: March 11, 2025
Encouraged
by
the
clinical
success
of
proteasome
inhibitors
treating
hematological
malignancy,
continuous
efforts
are
being
made
to
improve
their
efficacy
and
expand
applications
solid
tumor
therapy.
In
this
study,
liposomes
were
used
encapsulate
inhibitor
carfilzomib
(CFZ)
calcium
peroxide
(CaO2)
nanoparticles
for
effective
combination
therapy
targeting
interplay
between
overload
oxidative
stress.
Low-dose
CaO2
synergistically
enhances
anticancer
effect
CFZ
in
human
glioblastoma
U-87
MG
cells.
The
reactive
oxygen
species
(ROS)
generation
glutathione
depletion
low-dose
complement
CFZ-induced
ubiquitinated
protein
accumulation
further
triggering
endoplasmic
reticulum
(ER)
stress
leading
mitochondrial
dysfunction.
liposome-based
codelivery
system
is
capable
transporting
simultaneously
tumor,
results
a
superior
antitumor
tumor-bearing
mice
compared
with
monotherapy.
Taken
together,
holds
great
potential
sensitize
treatment
tumors,
work
also
presents
new
strategy
crosstalk
future
cancer
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Abstract
Cancer
immunotherapy,
which
leverages
the
body's
immune
system
to
combat
cancer,
offers
promise
of
lower
toxicity
and
higher
therapeutic
efficacy
compared
conventional
treatments.
However,
current
immunotherapeutic
approaches
face
significant
challenges
including
variable
patient
response,
immune‐related
adverse
events,
high
costs,
underscoring
urgent
need
for
innovative
strategies.
Metal‐based
nanomaterials
have
emerged
as
a
promising
avenue
in
cancer
immunotherapy
due
their
unique
physicochemical
properties
immune‐regulating
capabilities.
Despite
potential,
concerns
about
toxicity,
incomplete
understanding
modulation
mechanisms,
early‐stage
design
strategies
hinder
clinical
translation.
This
review
summarizes
recent
advancements
metal‐based
elucidates
mechanisms
by
they
enhance
antitumor
immunity
responses,
explores
potential
synergistic
effects
combining
multiple
metals.
We
also
discuss
key
future
perspectives
application,
aiming
provide
theoretical
foundation
development
immunotherapies
promote
broader
application
treatment.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 16, 2025
Abstract
The
cyclic
guanosine
monophosphate‐adenosine
monophosphate
synthase
(cGAS)‐stimulator
of
interferon
genes
(STING)
signaling
pathway
is
an
important
innate
immune
that
has
shown
remarkable
potential
in
cancer
immunotherapy.
However,
the
clinical
therapeutic
efficacy
limited
due
to
insufficient
penetration
STING
agonists
into
tumors.
In
this
study,
a
special
piezo‐STING
agonist
(ZnS‐Cur@CM,
Z/C@M)
composed
zinc
sulfide
nanosheets,
curcumin,
and
tumor
cell
membranes
based
on
principle
piezocatalytic
for
water
splitting
generate
gas
designed,
which
effectively
reduces
intratumoral
delivery
resistance,
markedly
enhancing
depth
drug
Under
ultrasound,
Z/C@M
rapidly
decomposes
interstitial
fluid
produce
hydrogen,
leading
decreased
pressure
increased
accumulation
within
tumor.
Additionally,
reactive
oxygen
species
generated
by
piezocatalysis
damage
mitochondria
cells,
resulting
release
mitochondrial
DNA
activation
cGAS‐STING
pathway.
Moreover,
released
Zn
2+
acidic
microenvironment
further
enhances
signal
transduction.
reduce
through
improve
tumors,
also
activates
treatment.
This
study
provides
novel
perspective
