Amplifying Ca2+ Overload by Engineered Biomaterials for Synergistic Cancer Therapy DOI
Jun‐Long Liang, Yangyang Cao, Kangle Lv

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123027 - 123027

Published: Dec. 15, 2024

Language: Английский

Role of Oxidative Stress in the Occurrence, Development, and Treatment of Breast Cancer DOI Creative Commons
Rui Dong, Jing Wang,

Rijian Guan

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 104 - 104

Published: Jan. 17, 2025

Breast cancer is one of the most prevalent cancers worldwide. Recent studies have increasingly emphasized role oxidative stress in initiation and progression breast cancer. This article reviews how imbalance influences occurrence advancement cancer, elucidating intricate mechanisms through which reactive oxygen species (ROS) operate this context their potential therapeutic applications. By highlighting these critical insights, review aims to enhance our understanding as a target for innovative strategies management

Language: Английский

Citations

3
Bidirectional Amplification of Oxidative Stress via Mitochondria-Targeted Co-Delivery of Nanogolds and Chlorin e6 Using ROS-Responsive Organosilica Nanocarriers DOI
Dongsheng Yu, Jianming Yuan,

Chiyi Ou

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Functional Evolution of Gold Nanoclusters under Light‐Induction: From Fluorescence to Multi‐Enzyme Mimetic Transition DOI Open Access
Jing Yang,

Ruishu Xu,

Haiyan Li

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Gold nanoclusters (AuNCs) exhibit unique physicochemical properties but their functional transitions under external stimuli remain underexplored. This study reveals that ultraviolet (UV) irradiation triggers structural evolution in AuNCs, causing fluorescence loss while activating dual enzyme-mimetic activities. UV-induced particle enlargement and surface restructuring endow AuNCs with peroxidase-like (POD-like) laccase-like functionalities. The POD-like activity enables sensitive glucose detection human serum, the capability facilitates simultaneous degradation of phenolic pollutants wastewater. These light-responsive transformations demonstrate AuNCs' dynamic adaptability, bridging intrinsic catalytic properties. findings elucidate photo-regulation mechanisms nanomaterial functionality, proposing a novel strategy for designing multifunctional nanosystems applicable biosensing environmental remediation. work advances development adaptive nanomaterials programmable features biomedical ecological applications.

Language: Английский

Citations

0
A Spatiotemporally Controlled and Mitochondria-Targeted Prodrug of Hydrogen Sulfide Enables Mild Mitochondrial Uncoupling for the Prevention of Lipid Deposition DOI
Xian Zhang,

Mengjie Ye,

Yuxin Ge

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(21), P. 19188 - 19199

Published: Oct. 23, 2024

Mild mitochondrial uncoupling offers therapeutic benefits for various diseases like obesity by regulating cellular energy metabolism. However, effective chemical intervention tools inducing mild mitochondria-targeted are limited. Herein, we have developed a H2S prodrug M1 with unique property of on-demand photoactivated generation accompanied self-reporting fluorescence real-time tracking. Upon photoirradiation, decomposes in mitochondria to generate and turn-on fluorescent coumarin derivative the visualization quantification H2S. is confirmed induce reactive oxygen species (ROS)-dependent uncoupling, activating mitochondria-associated adenosine monophosphate-activated protein kinase (AMPK) suppress palmitic acid (PA)-induced lipid deposition hepatocytes. The functions induced strictly controlled mitochondria, representing fresh strategy prevent improve metabolic syndrome increasing expenditure.

Language: Английский

Citations

1
Triple-helix β-glucan-based self-assemblies, synthesis, characterization and anticarcinogenic effect DOI
Liqin Cai, Xiang Shao, Xiaoyan Mao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 286, P. 138427 - 138427

Published: Dec. 9, 2024

Language: Английский

Citations

0
Cell membrane camouflaged Cu-doped mesoporous polydopamine for combined CT/PTT/CDT synergistic treatment of breast cancer DOI Open Access
Di Meng, Shuoye Yang,

Lin Ju

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117539 - 117539

Published: Oct. 9, 2024

Language: Английский

Citations

0
Amplifying Ca2+ Overload by Engineered Biomaterials for Synergistic Cancer Therapy DOI
Jun‐Long Liang, Yangyang Cao, Kangle Lv

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123027 - 123027

Published: Dec. 15, 2024

Language: Английский

Citations

0