Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology DOI Creative Commons
Daniel Ejim Uti, Item Justin Atangwho, Esther Ugo Alum

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 24, 2025

Cancer treatments often exploit oxidative stress to selectively kill tumour cells by disrupting their lipid peroxidation membranes and inhibiting antioxidant enzymes. However, plays a dual role in cancer progression, acting as both promoter suppressor. Balancing through therapy remains challenge, excessive activity may compromise the efficacy of chemotherapy radiotherapy. This review explores antioxidants mitigating while maintaining treatment efficacy. It highlights recent advancements nanotechnology-based targeted delivery optimize therapeutic outcomes. A comprehensive literature was conducted using reputable databases, including PubMed, Scopus, Web Science, ScienceDirect. The search focused on publications from past five years (2020-2025), supplemented relevant studies earlier years. Keywords such "antioxidants," "lipid peroxidation," "nanotechnology therapy," "oxidative stress" were utilized. Relevant articles critically analysed, graphical illustrations created. Emerging evidence suggests that nanoparticles, liposomes, polymeric metal-organic frameworks, others, can effectively encapsulate control release minimizing systemic toxicity. Stimuli-responsive carriers with tumour-specific targeting mechanisms further enhance delivery. Studies indicate these strategies help preserve normal cells, mitigate stress-related damage, improve challenges bioavailability, stability, potential interactions standard therapies remain. Integrating nanotechnology antioxidant-based interventions presents promising approach for optimizing therapy. Future research should focus refining modulation strategies, assessing profiles during treatment, employing biomarkers determine optimal dosing. balanced use adverse effects.

Language: Английский

Harnessing the FOXO-SIRT1 axis: insights into cellular stress, metabolism, and aging DOI
Saurabh Gupta, Muhammad Afzal, Neetu Agrawal

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 26, 2025

Language: Английский

Citations

1
Targeting p70S6K1 Inhibits Glycated Albumin-Induced Triple-Negative Breast Cancer Cell Invasion and Overexpression of Galectin-3, a Potential Prognostic Marker in Diabetic Patients with Invasive Breast Cancer DOI Creative Commons

Fatimah Alanazi,

Abdulmonem A. Alsaleh, Mariam K. Alamoudi

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 612 - 612

Published: March 3, 2025

Background: There is an urgent need to identify new biomarkers for early diagnosis and development of therapeutic strategies diabetes mellitus (DM) patients who have invasive breast cancer (BC). We previously reported the increased activated form 70 kDa ribosomal protein S6 kinase 1 (phospho-p70S6K1) in a triple-negative BC (TNBC) cell line MDA-MB-231 exposed glycated albumin (GA) ductal carcinoma tissues from T2DM patients, compared untreated cells their non-diabetic counterparts, respectively. Objective: aimed explore function p70S6K1 GA-promoted TNBC progression. Methods: By employing small interference (si)RNA technology or blocking its activity using specific pharmacological inhibitor, we monitored invasion Transwell® inserts expression levels signaling proteins cancer-related Western blot. Results: In silico analysis revealed that high mRNA were associated with unfavorable prognosis progression advanced stages DM patients. The downregulation/blockade inhibited phosphorylation ERK1/2, downstream effector, key oncogenic protein, suppression GA-upregulated proteins, including enolase-2, capping CapG, galectin-3, cathepsin D, was observed after downregulation/blockade. Further validation analyses gene galectin-3 resulting poor overall survival disease-free survival. Conclusions: Targeting may present valuable strategy, while could serve as potential prognostic biomarker

Language: Английский

Citations

0
Molecular Insights into Oxidative Stress and Its Clinical Implications DOI Open Access
Maria Trapali,

Vasileios Pavlidis,

Πέτρος Καρκαλούσος

et al.

The Open Medicinal Chemistry Journal, Journal Year: 2025, Volume and Issue: 19(1)

Published: April 24, 2025

Oxidative stress plays a crucial role in the pathophysiology of numerous diseases, including cardiovascular disorders, diabetes, neurodegenerative conditions, and chronic kidney disease. Reactive oxygen species (ROS) reactive nitrogen (RNS) are key contributors to cellular damage through oxidative nitrosative stress, affecting processes such as apoptosis, inflammation, fibrosis. This review explores molecular mechanisms underlying its connection various enzymatic non-enzymatic antioxidants counteracting harmful effects. Emerging therapeutic strategies, Nrf2 activators mitochondria-targeted antioxidants, highlighted promising tools for disease prevention treatment. Understanding interplay between progression can pave way precision medicine approaches, offering more personalized effective treatments.

Language: Английский

Citations

0
Molecular characterization of NOS3 and SOD1 genes as markers for detecting patients with breast cancer DOI
Mohammed Dlshad Mohsin, Abbas Salihi

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: May 19, 2025

Language: Английский

Citations

0
The Role of Diet and Nutrition in Cancer Development and Management: From Molecular Mechanisms to Personalized Interventions DOI Creative Commons
M. S. Ruban,

Elizaveta Pozhidaeva,

Л. В. Болотина

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(10), P. 1788 - 1788

Published: May 18, 2025

Diet plays a crucial role in cancer development and progression, beyond traditional risk factors. This review aims to summarize current evidence on the of diet specific nutrients focusing molecular mechanisms. We also discuss potential personalized dietary interventions, based tumor patient characteristics, enhancing prevention treatment strategies. The covers impact calories, protein, sugar, other components signaling pathways growth factors involved carcinogenesis. examine influence obesity, insulin resistance, metabolic outcomes. article explores strategies, including calorie restriction, ketogenic diets, gut microbiome modulating response anticancer therapies. Finally, we highlight need for further research develop targeted, recommendations an individual’s profile, stage disease, clinical Integrating such approaches into holds promise improving outcomes quality life.

Language: Английский

Citations

0
The association between oxidative balance scores and all-cause mortality and cancer-specific mortality in cancer survivors: a retrospective cohort study DOI Creative Commons
Ruxuan He,

Qilei Zhu,

Y. Ye

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 21, 2025

Background Numerous studies have established that oxidative stress significantly affects the long-term survival of cancer survivors. However, there is currently no comprehensive measure to assess levels in these individuals associates with all-cause, cause-specific, and cardiovascular disease (CVD) mortality. This study aims investigate relationship between Oxidative Balance Score (OBS) American survivors their risks cancer-specific, CVD Methods research included from National Health Nutrition Examination Survey dataset covering 2001–2018 cycles, incorporating appropriate weighting. The OBS, a composite index reflecting status, was constructed based on 16 dietary components 4 lifestyle factors, higher OBS indicating greater antioxidant capacity. Using multivariable Cox regression, restricted cubic splines analysis (RCS), subgroup analysis, sensitivity we examined associations mortality, including further stratified analyses for specific types populations. Results enrolled 2,131 eligible survivors, median follow-up 115 months 673 recorded deaths. Weighted regression results showed each unit increase associated 3% decrease all-cause mortality (Hazard Ratios [HR]: 0.97, 95% Confidence interval [CI]: 0.95, 0.99, p = 0.006). Among participants, those highest quartile (Q4) had 40% lower risk compared lowest (Q1) (HR: 0.60, CI: 0.41, 0.88, 0.009). A similar significant association found cancer-specific while noted RCS highlighted linear negative association. Subgroup indicated stronger among breast patients, without stroke or arthritis individuals. Sensitivity confirmed robustness findings. Conclusion reveals both

Language: Английский

Citations

0
Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology DOI Creative Commons
Daniel Ejim Uti, Item Justin Atangwho, Esther Ugo Alum

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 24, 2025

Cancer treatments often exploit oxidative stress to selectively kill tumour cells by disrupting their lipid peroxidation membranes and inhibiting antioxidant enzymes. However, plays a dual role in cancer progression, acting as both promoter suppressor. Balancing through therapy remains challenge, excessive activity may compromise the efficacy of chemotherapy radiotherapy. This review explores antioxidants mitigating while maintaining treatment efficacy. It highlights recent advancements nanotechnology-based targeted delivery optimize therapeutic outcomes. A comprehensive literature was conducted using reputable databases, including PubMed, Scopus, Web Science, ScienceDirect. The search focused on publications from past five years (2020-2025), supplemented relevant studies earlier years. Keywords such "antioxidants," "lipid peroxidation," "nanotechnology therapy," "oxidative stress" were utilized. Relevant articles critically analysed, graphical illustrations created. Emerging evidence suggests that nanoparticles, liposomes, polymeric metal-organic frameworks, others, can effectively encapsulate control release minimizing systemic toxicity. Stimuli-responsive carriers with tumour-specific targeting mechanisms further enhance delivery. Studies indicate these strategies help preserve normal cells, mitigate stress-related damage, improve challenges bioavailability, stability, potential interactions standard therapies remain. Integrating nanotechnology antioxidant-based interventions presents promising approach for optimizing therapy. Future research should focus refining modulation strategies, assessing profiles during treatment, employing biomarkers determine optimal dosing. balanced use adverse effects.

Language: Английский

Citations

0