Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics DOI Creative Commons
Wenxin Chen,

Qiyan Guo,

Hong Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Micro- and nanoplastics, particularly those derived from food-contact materials like polyethylene terephthalate (PET), can damage gut barriers, making the gastrointestinal system more vulnerable to inflammation infections. Here, a probiotic-based drug delivery (EcNT@L) is devised mitigate nanoplastics-induced barrier dysfunction by modulating immunity microbiota. Escherichia coli Nissle 1917 (EcN) genetically engineered produce transforming growth factor-β (TGF-β) then modified with an Eudragit L100-55 coating. This probiotic acts as in vivo "drug factory", exerting anti-inflammatory immune-regulatory effects, improved retention bioavailability tract. EcNT@L effectively protects Caco-2 cells infections induced nano PET, primarily activating NF-κB signaling pathway. Besides, demonstrates superior therapeutic efficacy treating infection caused combined presence of PET Salmonella, outperforming commercial antibiotics due its ability modulate immune responses study highlights potential systems addressing dysfunctions, offering promising strategy for mitigating environmental impact micro- nanoplastics.

Language: Английский

Organ-on-a-Chip Applications in Microfluidic Platforms DOI Creative Commons

Ling An,

Yi Liu, Yaling Liu

et al.

Micromachines, Journal Year: 2025, Volume and Issue: 16(2), P. 201 - 201

Published: Feb. 10, 2025

Microfluidic technology plays a crucial role in organ-on-a-chip (OoC) systems by replicating human physiological processes and disease states, significantly advancing biomedical research drug discovery. This article reviews the design fabrication of microfluidic devices. It also explores how these technologies are integrated into OoC platforms to simulate environments, highlighting key principles, technological advances, diverse applications. Through case studies involving simulation multiple organs such as heart, liver, lungs, evaluates impact systems' on screening, toxicity assessment, personalized medicine. In addition, this considers technical challenges, ethical issues, future directions, looks ahead further optimizing functionality biomimetic precision OoCs through innovation, emphasizing its critical promoting medicine treatment strategies.

Language: Английский

Citations

0
Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics DOI Creative Commons
Wenxin Chen,

Qiyan Guo,

Hong Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Micro- and nanoplastics, particularly those derived from food-contact materials like polyethylene terephthalate (PET), can damage gut barriers, making the gastrointestinal system more vulnerable to inflammation infections. Here, a probiotic-based drug delivery (EcNT@L) is devised mitigate nanoplastics-induced barrier dysfunction by modulating immunity microbiota. Escherichia coli Nissle 1917 (EcN) genetically engineered produce transforming growth factor-β (TGF-β) then modified with an Eudragit L100-55 coating. This probiotic acts as in vivo "drug factory", exerting anti-inflammatory immune-regulatory effects, improved retention bioavailability tract. EcNT@L effectively protects Caco-2 cells infections induced nano PET, primarily activating NF-κB signaling pathway. Besides, demonstrates superior therapeutic efficacy treating infection caused combined presence of PET Salmonella, outperforming commercial antibiotics due its ability modulate immune responses study highlights potential systems addressing dysfunctions, offering promising strategy for mitigating environmental impact micro- nanoplastics.

Language: Английский

Citations

0