Antibacterial collagen-guar gum hydrogels with zeolitic imidazolate framework-67 (ZIF-67): an innovative platform for advanced wound healing

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: April 1, 2025

The current challenge in developing wound healing dressings lies achieving antibacterial effects while avoiding cytotoxicity to cells that are crucial for the process. Addressing this challenge, Zeolitic Imidazolate Framework-67 (ZIF-67), a cobalt-containing metal-organic framework (MOF), has emerged as promising additive due cobalt's broad-spectrum antimicrobial effects. This study developed semi-interpenetrating polymer network (semi-IPN) hydrogels by incorporating 1-3 wt.% ZIF-67 into collagen-guar gum matrices, resulting biocomposites with tunable structural and functional properties. These exhibit fibrillar-granular morphology, uniform cobalt ion distribution on semi-crystalline surface, strong activity against Escherichia coli (E. coli). At 3 wt.%, accelerates gelation, strengthens crosslinking interactions, enhances storage modulus, thermal stability, hydrolytic resistance of hydrogels. Furthermore, 1 also function in-situ curcumin delivery systems, offering controlled release under physiological conditions significant biodegradation presence collagenase. In vitro tests demonstrate chemical composition these hydrogels, regardless content, effectively supports monocyte fibroblast metabolic activity, promotes cell proliferation, increases interleukin-10 (IL-10) secretion human monocytes. Additionally, absence hemolytic blood further underscores safety suitability hydrogel advanced treatment applications.

Language: Английский

Piezoelectric barium titanate/ PVDF-HFP nanocomposite-mediated soft ultrasound assisted organic dye degradation and antibacterial therapy against Bacillus subtilis and Vibrio cholerae

Materials Today Sustainability, Journal Year: 2025, Volume and Issue: unknown, P. 101102 - 101102

Published: April 1, 2025

Language: Английский

Galectin-1-Targeted Theranostic Nanoprobe for Multimodal Imaging and Photothermal Therapy in Cervical Cancer Lymph Node Metastases

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114714 - 114714

Published: April 1, 2025

Language: Английский