Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157041 - 157041
Published: Oct. 1, 2024
Language: Английский
Research, Journal Year: 2024, Volume and Issue: 7
Published: Jan. 1, 2024
Islet transplantation has now become a promising treatment for insulin-deficient diabetes mellitus. Compared to traditional treatments, cell therapy can restore endogenous insulin supplementation, but its large-scale clinical application is impeded by donor shortages, immune rejection, and unsuitable sites. To overcome these challenges, an increasing number of studies have attempted transplant hydrogel-encapsulated islet cells treat diabetes. This review mainly focuses on the strategy pancreatic diabetic therapy, including different sources encapsulated in hydrogels, encapsulation methods, hydrogel types, series accessorial manners improve outcomes. In addition, formation challenges as well prospects are also presented.
Language: Английский
Citations
4
Small Structures, Journal Year: 2024, Volume and Issue: unknown
Published: July 28, 2024
Atopic dermatitis (AD), a chronic and inflammatory skin disease, has brought huge physiological psychological burdens to patients, which causes wide concerns in society. Herein, multifunctional microneedle (MN) patch is proposed integrated with desirable moisturizer intelligent drug delivery capacity for AD treatment. Such MN consists of hyaluronic acid (HA) backing near‐infrared (NIR) responsive tips containing black phosphorous quantum dots (BPQDs), low‐melting agarose, polyvinylpyrrolidone (PVP), triamcinolone acetonide (TA). Among them, the soluble HA serves as long‐term relieving dryness symptoms AD. By introducing NIR excitable photothermal BPQDs into state composite material can be adjusted intelligently via NIR, thus achieving controllable release encapsulated TA tips. Besides, PVP enough mechanical strength help MNs successfully penetrate thickened patients. Based on these advantages, it demonstrated that reveals satisfactory therapeutic effect model Balb/c mice. These results indicate potential values treatment diseases other related biomedical fields.
Language: Английский
Citations
4
Smart Medicine, Journal Year: 2025, Volume and Issue: 4(1)
Published: Feb. 26, 2025
Wound healing has been a continuous critical focus in clinical practice, posing the ongoing challenges and burdens to patients. Current attempts tend develop multi-drug loaded patches with spatial design. Herein, we present multifunctional microneedle patch that integrates different drugs into separated regions for wound treatment. The is composed of silk fibroin-methacryloyl (SilMA) as base, silver nanoparticles (AgNPs) gelatin methacryloyl (GelMA) tips vascular endothelial growth factor (VEGF). backing endowed antimicrobial properties by AgNPs act an barrier against bacterium invasion. In addition, encapsulated VEGF can effectively promote cell proliferation angiogenesis, which favorable repair. Based on these characteristics, such integrated system significantly prevented bacterial infection promoted vivo. Therefore, it conceived find more practical values other fields.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 17, 2025
Inner ear disorders are among the predominant etiology of hearing loss. The blood-labyrinth barrier limits ability drugs to attain pharmacologically effective concentrations within inner ear; consequently, delivering systemically is insufficient for effectively treating disorders. Hence, it imperative create efficient, minimal or non-invasive methods administering ear. However, development such a system hindered by three main factors: anatomical unavailability, lack sustained drug delivery, and individual variability. Advances in biomaterials technology have created new opportunities overcoming existing barriers, offering great hope treatment Hydrogel- nanoparticle-based delivery systems can carry targeted designated locations long-term, release. Furthermore, range devices, including microneedles, micropumps, cochlear implants, when paired with biomaterials, enhance ear, making more effective. Therefore, biomaterial-based offer possibility extensive clinical uses promise restore millions patients
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 16, 2025
As the prevalence of metabolic diseases such as diabetes and obesity continue to rise, search for more effective convenient treatments has become a crucial issue in medical research. Microneedles (MNs), an innovative drug delivery system, have shown advantages treatment recent years. MNs-based which use MNs deliver drugs directly subcutaneous tissue, improve bioavailability reduce systemic side effects. This review aims summarize latest concepts, designs, types MNs, investigate materials manufacturing methods used their construction. Subsequently, mechanisms graded release research progress are further summarized. article focuses on application common diseases, with special emphasis optimization diabetic anti-obesity MNs. The main challenges future perspectives production evaluation well enhancing efficacy improving safety, elucidated.
Language: Английский
Citations
0
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(20), P. 5134 - 5149
Published: Jan. 1, 2024
This review discusses the application of microneedle technology in biomedical detection, emphasizing advantages painless and minimally invasive testing, points out future prospects healthcare.
Language: Английский
Citations
3
Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Language: Английский
Citations
3
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156130 - 156130
Published: Sept. 1, 2024
Language: Английский
Citations
3
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 5, 2024
Abstract Microneedles (MNs), composed of an array micro‐sized needles and a supporting base, have transcended their initial use to replace hypodermic in drug delivery fluid collection, advancing toward multifunctional platforms. In this review, four major areas are summarized interdisciplinary engineering approaches combined with MNs technology. First, electronics engineering, the most extensively researched field, enables applications biomonitoring, electrical stimulation, closed‐loop theranostics through generation, transmission, transformation signals. Second, electromagnetic responsiveness induction offers prospects for remote programmable therapeutic applications. Third, photonic endows novel functionalities, such as waveguiding manipulation enhance optical capabilities facilitate visualization disease progression treatment processes. Lastly, it reviewed role mechanical conferring shape adaptability motion features necessary various This review focuses on functionalities that emerge from intersection complementary technologies, aiming inspire further research innovation microneedle technology biomedical
Language: Английский
Citations
3
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(21), P. 25417 - 25426
Published: May 17, 2023
Bacterial biofilms pose severe threats to public health worldwide and are intractable by conventional antibiotic treatment. Antimicrobial photodynamic therapy (PDT) is emerging as a promising strategy for eradicating virtue of low invasiveness, broad-spectrum antibacterial activity, nondrug resistance. However, its practical efficacy impeded the water solubility, aggregation, poor penetration photosensitizers (PSs) into dense extracellular polymeric substances (EPS) biofilms. Herein, we develop dissolving microneedle (DMN) patch composed sulfobutylether-β-cyclodextrin (SCD)/tetra(4-pyridyl)-porphine (TPyP) supramolecular PS enhanced biofilm eradication. The inclusion TPyP SCD cavity can drastically inhibit aggregation TPyP, thereby allowing nearly tenfold reactive oxygen species production high efficacy. Moreover, TPyP/SCD-based DMN (TSMN) possesses excellent mechanical performance that easily pierce EPS with depth ∼350 μm, enabling sufficient contact bacteria optimal elimination bacterial Furthermore, TSMN could efficiently eradicate Staphylococcus aureus infection in vivo good biosafety. This study offers platform efficient other PDTs.
Language: Английский
Citations
8