Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Abstract
Nerve
guidance
conduits
have
demonstrated
great
promise
for
the
restoration
of
injured
peripheral
nerves
in
recent
decades.
Associated
research
has
focused
on
improving
structure
and
function
these
as
well
simplifying
manufacturing
processes.
Herein,
a
novel
decellularized
umbilical
cord
(DUC)
wrapped
with
conductive
hydrogel
is
presented
nerve
regeneration,
which
prepared
by
integrating
DUC
matrix
into
methacrylate
gelatin
(GelMA)/Ti
3
C
2
T
x
MXene
(MXene)
composite
hollow
conduit
(named
DUC–MXene–GelMA
conduit).
The
obtained
displays
superior
mechanical
properties,
electrical
conductivity,
biocompatibility.
Particularly,
ascribed
to
introduction
MXene,
exhibits
satisfactory
biological
effects
promoting
neuron
growth
Schwann
cell
proliferation
migration.
Through
vivo
experiments
using
rat
sciatic
injury
model,
beneficial
axonal
regeneration
motor
recovery
are
demonstrated.
These
findings
indicate
that
may
be
promising
candidate
repair.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Cancer
immunotherapy,
which
leverages
immune
system
components
to
treat
malignancies,
has
emerged
as
a
cornerstone
of
contemporary
therapeutic
strategies.
Yet,
critical
concerns
about
the
efficacy
and
safety
cancer
immunotherapies
remain
formidable.
Nanotechnology,
especially
polymeric
nanoparticles
(PNPs),
offers
unparalleled
flexibility
in
manipulation‐from
chemical
composition
physical
properties
precision
control
nanoassemblies.
PNPs
provide
an
optimal
platform
amplify
potency
minimize
systematic
toxicity
broad
spectrum
immunotherapeutic
modalities.
In
this
comprehensive
review,
basics
polymer
chemistry,
state‐of‐the‐art
designs
from
physicochemical
standpoint
for
encompassing
vaccines,
situ
vaccination,
adoptive
T‐cell
therapies,
tumor‐infiltrating
cell‐targeted
antibodies,
cytokine
therapies
are
delineated.
Each
immunotherapy
necessitates
distinctively
tailored
design
strategies
nanoplatforms.
The
extensive
applications
PNPs,
investigation
their
mechanisms
action
enhanced
particularly
focused
on.
profiles
clinical
research
progress
discussed.
Additionally,
forthcoming
developments
emergent
trends
nano‐immunotherapeutics
poised
transform
treatment
paradigms
into
clinics
explored.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
Abstract
Dentin
hypersensitivity
(DH),
marked
by
exposed
dentinal
tubules,
presents
as
a
sharp
toothache
triggered
stimuli
and
subsides
when
the
are
removed.
To
address
limitations
of
current
commercial
desensitizers
in
terms
acid
resistance,
friction
stability,
black
phosphorus
nanosheet‐composited
methacrylate
gelatin
hydrogel
(GelMA/BP)
is
developed
for
DH
treatment,
leveraging
synergistic
effects
photothermal
therapy
biomineralization.
Incorporating
BP
nanosheet
provided
GelMA/BP
with
stable
response
continuous
release
phosphate
anions,
which
blocked
tubules
converting
light
energy
into
heat
initiating
In
vitro
desensitizing
showed
that
tubule
diameter
GelMA/BP50
group
(0−1.13
µm)
significantly
reduced
compared
to
DH‐model
(0−3.14
µm).
The
achieved
an
86%
occlusion
rate,
resistance
80%,
76%,
long‐term
stability
74%.
vivo
studies
further
validated
efficacy
GelMA/BP50,
showing
reduction
(0−0.37
rate
79%,
alleviated
increased
intake
weight.
These
results
demonstrate
this
acts
effective
sealant,
offering
promising
clinical
benefits
topical
treatment
DH.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 6, 2025
Traumatic
brain
injury
(TBI)
represents
a
significant
global
public
health
issue,
with
effective
management
posing
numerous
challenges.
The
pathophysiology
of
TBI
is
typically
categorized
into
two
phases:
primary
and
secondary
injuries.
Secondary
involves
pathophysiological
mechanisms
such
as
blood-brain
barrier
(BBB)
disruption,
mitochondrial
dysfunction,
oxidative
stress,
inflammatory
responses.
Current
pharmacological
strategies
often
encounter
obstacles
in
treating
effectively,
primarily
due
to
challenges
BBB
penetration,
inadequate
target
site
accumulation,
off-target
toxicity.
Versatile
hydrogels
nanoparticles
offer
potential
solutions
these
limitations.
This
review
discusses
recent
progress
utilizing
for
treatment
over
the
past
5
years,
highlighting
their
relevance
underlying
pathophysiology.
Hydrogels
demonstrate
substantial
promise
addressing
injury,
providing
broad
spectrum
future
therapeutic
opportunities.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(19)
Published: March 13, 2024
Abstract
Efferocytosis,
an
intrinsic
regulatory
mechanism
to
eliminate
apoptotic
cells,
will
be
suppressed
due
the
delayed
apoptosis
process
in
aging‐related
diseases,
such
as
osteoarthritis
(OA).
In
this
study,
cartilage
lesion‐localized
hydrogel
microspheres
are
developed
remodel
situ
efferocytosis
reverse
senescence
and
recruit
endogenous
stem
cells
accelerate
repair.
Specifically,
aldehyde‐
methacrylic
anhydride
(MA)‐modified
hyaluronic
acid
(AHM),
loaded
with
pro‐apoptotic
liposomes
(liposomes
encapsulating
ABT263,
A‐Lipo)
PDGF‐BB,
namely
A‐Lipo/PAHM,
prepared
by
microfluidic
photo‐cross‐linking
techniques.
By
a
degraded
porcine
explant
OA
model,
lesion
location
experiment
illustrated
that
aldehyde‐functionalized
promote
affinity
for
cartilage.
vitro
data
showed
A‐Lipo
induced
of
senescent
chondrocytes
(Sn‐chondrocytes),
which
can
then
phagocytosed
macrophages,
remodeling
facilitated
protection
normal
maintained
chondrogenic
differentiation
capacity
MSCs.
vivo
experiments
confirmed
localized
reversed
promoted
repair
OA.
It
is
believed
strategy
great
significance
tissue
regeneration
diseases.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
25, P. 100976 - 100976
Published: Jan. 28, 2024
Osteonecrosis
is
a
devastating
orthopedic
disease
in
clinic
that
generally
occurs
the
femoral
head
associating
with
corticosteroid
use
up
to
49
%
patients.
In
particular,
glucocorticoids
induced
osteonecrosis
of
closely
related
local
immune
response
characterized
by
abnormal
macrophage
activation
and
inflammatory
cell
infiltration
at
necrotic
site,
forming
pro-inflammatory
microenvironment
dominated
M1
macrophages,
thus
leads
failure
bone
repair
regeneration.
Here,
we
report
regeneration
strategy
constructs
an
regulatory
biomaterial
platform
using
injectable
thiolated
hyaluronic
acid
hydrogel
lithium-doped
nano-hydroxyapatite
(Li-nHA@Gel)
delivery
for
treatment.
Li-nHA@Gel
achieved
sustain
longterm
release
Li
ions,
which
might
enhance
M2
polarization
through
JAK1/STAT6/STAT3
signaling
pathway,
following
pro-repair
mediated
enhancement
osteogenic
angiogenic
differentiation.
Moreover,
both
vitro
vivo
studies
indicated
enhanced
polarization,
osteogenesis,
angiogenesis,
promoted
blood
vessel
formation.
Taken
together,
this
novel
immunomodulatory
promotes
enhancing
angiogenesis
could
be
promising
Materials,
Journal Year:
2024,
Volume and Issue:
17(10), P. 2439 - 2439
Published: May 18, 2024
This
comprehensive
review
delves
into
the
world
of
hyaluronic
acid
(HA)
hydrogels,
exploring
their
creation,
characteristics,
research
methodologies,
and
uses.
HA
hydrogels
stand
out
among
natural
polysaccharides
due
to
distinct
features.
Their
exceptional
biocompatibility
makes
them
a
top
choice
for
diverse
biomedical
purposes,
with
great
ability
coexist
harmoniously
living
cells
tissues.
Furthermore,
biodegradability
permits
gradual
breakdown
by
bodily
enzymes,
enabling
creation
temporary
frameworks
tissue
engineering
endeavors.
Additionally,
since
is
vital
component
extracellular
matrix
(ECM)
in
numerous
tissues,
can
replicate
ECM's
structure
functions.
mimicry
pivotal
applications
providing
an
ideal
setting
cellular
growth
maturation.
Various
cross-linking
techniques
like
chemical,
physical,
enzymatic,
hybrid
methods
impact
mechanical
strength,
swelling
capacity,
degradation
speed
hydrogels.
Assessment
tools
such
as
rheological
analysis,
electron
microscopy,
spectroscopy,
tests,
studies
are
employed
examine
attributes.
HA-based
feature
prominently
engineering,
drug
distribution,
wound
recovery,
ophthalmology,
cartilage
mending.
Crafting
enables
production
biomaterials
sought-after
qualities,
offering
avenues
advancements
realm
biomedicine.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(46)
Published: June 19, 2024
Abstract
The
presence
of
bacterial
persisters
is
a
key
factor
contributing
to
chronic
infection.
However,
no
effective
treatment
methods
are
currently
available.
Thus,
platform
developed,
called
reactive
oxygen
species
(ROS)
bomb,
based
on
microenvironment‐adaptive
hydrogel
microspheres,
oxidize
the
cell
membranes
in
periprosthetic
joint
infection
(PJI).
Fenton
reagent
hydroxy
iron
oxide
(FeOOH)
and
glucose
oxidase
(GOx)/calcium
phosphate
(CaP)
acid‐responsive
shell
sequentially
induced
surface
mesoporous
polydopamine
(PDA)
nanoparticles
by
PDA‐mediated
ion
precipitation
interfacial
adhesion,
followed
coloaded
with
into
microfluidic
hyaluronic
acid
microspheres.
Hydroxyl
radicals
explosively
generated
through
GOx‐mediated
oxidase,
H
2
O
production,
its
Fenton‐like
reactions
FeOOH,
which
also
benefit
from
weakly
acidic
microenvironment
around
persisters,
result
destruction
membrane,
subsequent
overflow
cellular
contents
such
as
dsDNA,
proteins,
K
+
.
bactericidal
rates
methicillin‐resistant
Staphylococcus
aureus
epidermidis
up
99.14%
98.96%,
loads
lesion
location
significantly
decreased
after
ROS
bombs
treated,
effectively
alleviated
inflammation
bone
resorption
damage.
This
work
provides
new
strategy
toward
clearance
shows
great
application
potential
other
infection‐related
diseases.
