Recent advances in the development of metallodrugs for cancer chemoimmunotherapy DOI

Fangmian Wei,

Jinzhe Liang, Xing‐Can Shen

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 526, P. 216319 - 216319

Published: Nov. 28, 2024

Language: Английский

Novel zinc(II) phthalocyanine nanoparticles as diagnosis-treatment nanoprobe for photoacoustic imaging-guided synergistic photothermal/photodynamic-enhanced cancer therapy DOI
Min He,

Yidong Bin,

Lixian Huang

et al.

Inorganic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this work, novel zinc( ii ) phthalocyanine nanoparticles (ZnPcNPs) have been developed and verified to be a promising PTT/PDT agent with high photoconversion efficiency of 30.01% under 660 nm NIR-I laser exposure.

Language: Английский

Citations

0
Metal-based immunogenic cell death inducers for cancer immunotherapy DOI Creative Commons
Jun Zou, Meng Rui Chang, Nikita A. Kuznetsov

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Immunogenic cell death (ICD) has attracted enormous attention over the past decade due to its unique characteristics in cancer and role activating innate adaptive immune responses against tumours. Many efforts have been dedicated screening, identifying discovering ICD inducers, resulting validation of several based on metal complexes. In this review, we provide a comprehensive summary current metal-based their molecular mechanisms for triggering initiation subsequent protective antitumour responses, along with considerations validating both vitro vivo. We also aim offer insights into future development complexes enhanced ICD-inducing properties applications potentiating immunity.

Language: Английский

Citations

0
Supramolecular approaches for the treatment of hypoxic regions in tumours DOI
Irene Regeni, Sylvestre Bonnet

Nature Reviews Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Citations

0
Photo-Activated Ferrocene-Iridium(III) Prodrug Induces Immunogenic Cell Death in Melanoma Stem Cells DOI

Qiaoshan Lie,

Hui Jiang, Xiangwan Lu

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Cancer stem cells (CSCs) are key contributors to tumor resistance, recurrence, and metastasis. Conventional chemotherapy often fails target eradicate CSCs, significantly impairing their therapeutic efficacy. Herein, we design synthesize a photoactivated ferrocene-iridium(III) complex (Ir-3) achieve immunotherapy against melanoma (including cells). In short, Ir-3 effectively targets mitochondria dissociates under light irradiation produce cytotoxic Ir(III) photosensitizer Fe2+ ions. They can generate reactive oxygen species by the Fenton reaction, robustly induce ferroptosis autophagy, eventually trigger immunogenic cell death in Furthermore, exposure, inhibits cell-related properties promotes macrophage-mediated phagocytosis of cells. For vivo studies, is encapsulated DSPE-PEG 2000 form tumor-targeting Ir-3@PEG nanoparticles. After photoactivation, inhibit primary distant tumors, stemness cells, innate adaptive immune responses.

Language: Английский

Citations

0
Recent advances in the development of metallodrugs for cancer chemoimmunotherapy DOI

Fangmian Wei,

Jinzhe Liang, Xing‐Can Shen

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 526, P. 216319 - 216319

Published: Nov. 28, 2024

Language: Английский

Citations

3