PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic Framework with Effective Nanozyme Performance and Cuproptosis Induction Efficacy for Enhanced PD-L1-based Immunotherapy

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101317 - 101317

Published: Oct. 30, 2024

Language: Английский

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Metal-based immunogenic cell death inducers for cancer immunotherapy

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Immunogenic cell death (ICD) has attracted enormous attention over the past decade due to its unique characteristics in cancer and role activating innate adaptive immune responses against tumours. Many efforts have been dedicated screening, identifying discovering ICD inducers, resulting validation of several based on metal complexes. In this review, we provide a comprehensive summary current metal-based their molecular mechanisms for triggering initiation subsequent protective antitumour responses, along with considerations validating both vitro vivo. We also aim offer insights into future development complexes enhanced ICD-inducing properties applications potentiating immunity.

Language: Английский

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Tumor-targeting Nanomaterials Based on Metal-organic Frameworks Mediate Tumor Immunotherapy by Promoting Cuproptosis and Pyroptosis in Hepatocellular Carcinoma Cells

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101745 - 101745

Published: April 1, 2025

Language: Английский

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Biomimetic Copper Nanozyme Reprograms Cold Tumor via Cuproptosis–Pyroptosis Crosstalk for Potent Renal Carcinoma Immunotherapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Immune checkpoint blockade (ICB) therapy is an emerging strategy for renal cell carcinoma (RCC). However, its clinical efficacy remains constrained by inherently poor immunogenicity and insufficient cytotoxic T lymphocyte (CTL) infiltration. Herein, we engineer a biomimetic copper nanozyme (Cu2O-OMV) integrating Cu2O nanoparticles with bacterial outer-membrane vesicles (OMVs) to activate the antitumor immune response synergize ICB therapy. The Cu2O-OMV exhibits peroxidase (POD)-like catalytic activity releases Cu+ exert Fenton-like activity, generating hydroxyl radicals (·OH) tumor inhibition. Furthermore, accumulation promotes occurrence of cuproptosis, leading mitochondrial aggregation lipoylated dihydrolipoamide S-acetyltransferase depletion ferredoxin 1. Notably, concurrently activates pyroptosis via noncanonical inflammasome pathway through intrinsic lipopolysaccharide cargo, directly inhibiting growth inducing inflammatory cytokine release. coordinated induction cuproptosis synergistically amplifies immunogenic death enhance immunogenicity, thereby promoting dendritic maturation CTL After combining αPD-L1, it effectively destroys cells response, metastasis. Our study demonstrates nanozyme-driven that harnesses dual cuproptosis-pyroptosis pathways amplify efficacy, offering transformative approach RCC immunotherapy.

Language: Английский

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Microwave‐Responsive AlEu‐MOFs Potentiate NLRP3‐Mediated Pyroptosis via a “Triple Initiating” Tactic for Breast Cancer Microwave‐Immunotherapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Microwave thermotherapy is favored in clinical practice for breast cancer conservation strategies due to its minimally invasive characteristic. Nevertheless, the immunosuppressive tumor microenvironment (TME) significantly attenuates therapeutic efficacy of anti‐tumor immune response, posing challenges effectively preventing recurrence and metastasis. Pyroptosis, a recently identified form programmed cell death triggered by inflammasomes, presents unique inflammatory immunogenic properties that hold promise immunotherapy. Herein, microwave‐responsive AlEu‐MOFs are designed synthesized boost NLRP3‐mediated pyroptosis via “Triple Initiating” tactic microwave‐immunotherapy. The potent microwave thermal effect AEM facilitates up‐regulation HSP90, thereby initiating NLRP3 expression. Concurrently, it induces mitochondrial dysfunction generate substantial quantities ROS, further enhancing expression achieve targeted amplification thermotherapy‐induced pyroptosis. Simultaneously, directed anchoring release highly active metal ions promotes activation inflammasome jointly, ultimately inducing high‐efficiency This innovative “2M” (materials methods) dual‐pronged strategy not only inhibits primary proliferation, but also impedes distant progression lung work provides novel accurately offers new approach overcome obstacles thermotherapy.

Language: Английский

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Cuproptosis-Driven Nanostrategies: Synergistic Nanoplatforms for Tumor Microenvironment Reprogramming and Enhanced Anticancer Efficacy

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101894 - 101894

Published: May 1, 2025

Language: Английский

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Cuproptosis and Cuproptosis‐Based Synergistic Therapy for Cancer Treatment

ChemMedChem, Journal Year: 2024, Volume and Issue: 19(21)

Published: June 29, 2024

Abstract Copper, as an essential trace nutrient for human, plays a crucial role in numerous cellular activities, and is vital maintaining homeostasis organisms. Deviations from normal intracellular copper concentration range can disrupt the lead to cell death. Cell death process which cells lose their vitality cannot sustain metabolism, has various forms. The recently discovered cuproptosis mechanism differs previously recognized forms, triggered by accumulation. discovery of sparked interest among researchers, this been applied treatment intractable diseases, including different types cancer. However, developed cuproptosis‐based therapies have revealed certain limitations, such low immunostimulatory efficiency, poor tumor targeting, inhibition microenvironment. Therefore, researchers are devoted combining with existing cancer develop more effective synergistic therapies. This review summarizes latest research advancements cancer, focus on Finally, it provides outlook future development anti‐tumor therapy.

Language: Английский

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Ophthalmic Tethered Gold Yarnball‐Mediated Retained Drug Delivery for Eye Fundus Disease Treatment

Small Science, Journal Year: 2024, Volume and Issue: 4(8)

Published: June 27, 2024

Eye fundus diseases, such as retinal degenerative which lead to blindness in ≈12% of individuals aged >65 years, cause permanent damage cells. The antioxidant quercetin (QC) is promising for the effective treatment eye diseases; however, its poor solubility and low retention rate often limit clinical application. Herein, an situ ophthalmic tethered gold yarnball (GY) that doubles ocular agent QC reservoir overcome drug developed. After intravitreal injection, QC@GYs enhance cell leakage internal limiting membrane permeability, facilitating partial penetration into intraretinal tissue. combination retina‐tethered QC@GY first‐level sustained release reduces macular degeneration vivo by effectively regulating oxidative stress. Furthermore, preserves viability pigment epithelium cells, apoptosis, suppresses drusen formation. This preservation morphology function maximizes therapeutic impact while minimizing need frequent intraocular administration. Overall, GY platform a versatile tool delivery diseases.

Language: Английский

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Targeted Therapy with Polymeric Nanoparticles in PBRM1-Mutant Biliary Tract Cancers: Harnessing DNA Damage Repair Mechanisms

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 204, P. 104505 - 104505

Published: Sept. 8, 2024

Language: Английский

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