Multifunctional PtCuTe Nanosheets with Strong ROS Scavenging and ROS‐Independent Antibacterial Properties Promote Diabetic Wound Healing

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)

Published: Sept. 19, 2023

Abstract Nanozymes, as one of the most efficient reactive oxygen species (ROS)‐scavenging biomaterials, are receiving wide attention in promoting diabetic wound healing. Despite recent attempts at improving catalytic efficiency Pt‐based nanozymes (e.g., PtCu, best systems), they still display quite limited ROS scavenging capacity and ROS‐dependent antibacterial effects on bacteria or immunocytes, which leads to uncontrolled poor Hence, a new class multifunctional PtCuTe nanosheets with excellent catalytic, ROS‐independent antibacterial, proangiogenic, anti‐inflammatory, immuno‐modulatory properties for boosting healing, is reported. The show stronger better than PtCu. It also revealed that can enhance vascular tube formation, stimulate macrophage polarization toward M2 phenotype improve fibroblast mobility, outperforming conventional Moreover, promotes crosstalk between different cell types form positive feedback loop. Consequently, stimulates proregenerative environment relevant populations ensure normal tissue repair. Utilizing mouse model, it demonstrated significantly facilitated regeneration highly vascularized skin, percentage closure being over 90% 8th day, among reported comparable biomaterials.

Language: Английский

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Versatile carbon dots with superoxide dismutase-like nanozyme activity and red fluorescence for inflammatory bowel disease therapeutics

Carbon, Journal Year: 2023, Volume and Issue: 204, P. 526 - 537

Published: Jan. 6, 2023

Language: Английский

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A Cardiac‐Targeted Nanozyme Interrupts the Inflammation‐Free Radical Cycle in Myocardial Infarction

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Nov. 21, 2023

Abstract Severe systemic inflammation following myocardial infarction (MI) is a major cause of patient mortality. MI‐induced can trigger the production free radicals, which in turn ultimately leads to increased cardiac lesions (i.e., inflammation‐free radicals cycle), resulting heart failure and death. However, currently available anti‐inflammatory drugs have limited efficacy due their weak effect poor accumulation at site. Herein, novel Fe‐Cur@TA nanozyme developed for targeted therapy MI, generated by coordinating Fe 3+ drug curcumin (Cur) with further modification tannic acid (TA). Such exhibits excellent scavenging properties reducing immune cell infiltration, promoting macrophage polarization toward M2‐like phenotype, suppressing inflammatory cytokine secretion, blocking cycle. Furthermore, high affinity TA tissue, shows an almost tenfold greater retention uptake than Fe‐Cur. In mouse preclinical beagle dog MI models, preserves function reduces scar size, suggesting promising potential clinical translation cardiovascular disease.

Language: Английский

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Activity Regulating Strategies of Nanozymes for Biomedical Applications

Small, Journal Year: 2023, Volume and Issue: 19(11)

Published: Jan. 17, 2023

Abstract On accounts of the advantages inherent high stability, ease preparation and superior catalytic activities, nanozymes have attracted tremendous potential in diverse biomedical applications as alternatives to natural enzymes. Optimizing activity is significant for widening boosting into practical level. As research regulation strategies boosting, it essential timely review, summarize, analyze advances structure–activity relationships further inspiring ingenious this prosperous area. Herein, methods recent 5 years are systematically summarized, including size morphology, doping, vacancy, surface modification, hybridization, followed by a discussion latest consisting biosensing, antibacterial, tumor therapy. Finally, challenges opportunities rapidly developing field presented more infant yet promising

Language: Английский

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Advances in Biodegradable Polymers and Biomaterials for Medical Applications—A Review

Molecules, Journal Year: 2023, Volume and Issue: 28(17), P. 6213 - 6213

Published: Aug. 24, 2023

The introduction of new materials for the production various types constructs that can connect directly to tissues has enabled development such fields science as medicine, tissue, and regenerative engineering. implementation these materials, called biomaterials, contributed a significant improvement in quality human life terms health. This is due constantly growing availability implants, prostheses, tools, surgical equipment, which, thanks their specific features biocompatibility, appropriate mechanical properties, ease sterilization, high porosity, ensure an living. Biodegradation ensures, among other things, ideal rate regenerated tissue. Current tissue engineering medicine strategies aim restore function damaged tissues. current gold standard autografts (using patient’s accelerate healing), but limitations limited procurement certain tissues, long operative time, donor site morbidity have warranted search alternative options. use biomaterials this purpose attractive option number being developed tested rapidly.

Language: Английский

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Augmenting Cancer Therapy with a Supramolecular Immunogenic Cell Death Inducer: A Lysosome-Targeted NIR-Light-Activated Ruthenium(II) Metallacycle

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(13), P. 8991 - 9003

Published: March 21, 2024

Though immunogenic cell death (ICD) has garnered significant attention in the realm of anticancer therapies, effectively stimulating strong immune responses with minimal side effects deep-seated tumors remains challenging. Herein, we introduce a novel self-assembled near-infrared-light-activated ruthenium(II) metallacycle, Ru1105 (λem = 1105 nm), as first example Ru(II) supramolecular ICD inducer. synergistically potentiates immunomodulatory and reduces adverse through multiple regulated approaches, including NIR-light excitation, increased reactive oxygen species (ROS) generation, selective targeting tumor cells, precision organelle localization, improved penetration/retention capabilities. Specifically, demonstrates excellent depth-activated ROS production (∼1 cm), resistance to diffusion, anti-ROS quenching. Moreover, exhibits promising results cellular uptake generation cancer cells multicellular spheroids. Importantly, induces more efficient an ultralow dose (10 μM) compared conventional agent, oxaliplatin (300 μM). In vivo experiments further confirm Ru1105's potency inducer, eliciting CD8+ T depleting Foxp3+ effects. Our research lays foundation for design secure exceptionally potent metal-based agents immunotherapy.

Language: Английский

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Recent progress in nanozymes for the treatment of diabetic wounds

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(29), P. 6746 - 6761

Published: Jan. 1, 2023

The slow healing of diabetic wounds has seriously affected human health. Meanwhile, the open are susceptible to bacterial infection. Clinical therapeutic methods such as antibiotic therapy, insulin treatment, and surgical debridement have made great achievements in treatment wounds. However, drug-resistant bacteria will develop after long-term use antibiotics, resulting decreased efficacy. To improve effect, increasing drug concentration is a common strategy clinical practice, but it also brings serious side effects. In addition, hyperglycemia control or can easily bring negative effects patients, hypoglycemia damage normal tissue. Therefore, essential novel strategies effectively promote wound healing. recent years, nanozyme-based systems received extensive attention because they possess advantages nanomaterials natural enzymes. For example, nanozymes small size high surface area volume ratio, which enhance tissue penetration increase reactive active sites. Moreover, compared with enzymes, more stable catalytic activity, lower production cost, stronger operability. this review, we first reviewed basic characteristics then elaborated on mechanism action principle different types from three aspects: controlling infection, hyperglycemia, relieving inflammation. Finally, challenges, prospects future implementation for outlined.

Language: Английский

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Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Language: Английский

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Biomedical potential of nanozymes: Harnessing redox enzyme mimicry for theranostic applications

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215937 - 215937

Published: June 15, 2024

Language: Английский

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Nano oxygen chamber by cascade reaction for hypoxia mitigation and reactive oxygen species scavenging in wound healing

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 67 - 81

Published: Jan. 23, 2024

Hypoxia, excessive reactive oxygen species (ROS), and impaired angiogenesis are prominent obstacles to wound healing following trauma surgical procedures, often leading the development of keloids hypertrophic scars. To address these challenges, a novel approach has been proposed, involving cascade enzymatic reaction-based nanocarriers-laden dressing. This advanced technology incorporates superoxide dismutase modified nanobubbles catalase within an alginate hydrogel matrix. The nano chamber functions through reaction between catalase, wherein in environment is enzymatically decomposed into hydrogen peroxide, this peroxide subsequently converted by catalase. effectively controls inflammation hypoxia, mitigating risk keloid formation. Concurrently, release continuously, thus providing sustained supply site. from dynamic system stimulates fibroblast proliferation, fosters formation new blood vessels, contributes overall process. In rat full-thickness model, displayed notable capacity expedite without scarring. Furthermore, pilot study porcine healing, acceleration tissue repair was observed conceived gel treated group 3 days post-surgery, which represents proliferation stage These achievements hold significant importance ensuring complete functional recovery tissues, thereby highlighting its potential as promising for enhancing outcomes.

Language: Английский

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