Gelatin nanoparticles loaded with 3-alkylpyridinium salt APS7, an analog of marine toxin, are a promising support in human lung cancer therapy DOI Creative Commons
Veno Kononenko, Ahmad Joukhan, Tadeja Bele

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117007 - 117007

Published: June 20, 2024

This study demonstrates the potential of gelatin nanoparticles as a nanodelivery system for antagonists nicotinic acetylcholine receptors (nAChRs) to improve chemotherapy efficacy and reduce off-target effects. Too often, lung cancer does not lead satisfactory results. Therefore, new approaches directed at multiple pharmacological targets in therapy are being developed. Following activation nAChRs (e.g. by nicotine), cells begin proliferate become more resistant chemotherapy-induced apoptosis. work shows that 3-alkylpyridinium salt, APS7, synthetic analog toxin from marine sponge Haliclona (Rhizoneira) sarai, acts an nAChR antagonist inhibits pro-proliferative anti-apoptotic effects nicotine on A549 human adenocarcinoma cells. In this study, gelatin-based filled with APS7 (APS7-GNPs) were prepared their compared free APS7. Both APS7-GNPs inhibited Ca2+ influx increased cisplatin nicotine-stimulated However, significant benefits observed – stronger reduction proliferation much higher selectivity cytotoxicity towards non-tumorigenic epithelial BEAS-2B

Language: Английский

Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy DOI
Yuanying Yang, Chen Dong, Xuehua Ma

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.

Language: Английский

Citations

2
A nano drug delivery system loading drugs and chlorin e6 separately to achieve photodynamic-chemo combination therapy DOI
Geng Yin, Hongli Zhao, Minbo Lan

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 4, 2025

Aim To develop a new drug delivery system (DDS) that can load chemotherapy agents and photosensitizer chlorin e6 (Ce6) onto the pores surfaces of mesoporous silica nanoparticle (MSN) separately.

Language: Английский

Citations

1
Enhancing glioma-specific drug delivery through self-assembly of macrophage membrane and targeted polymer assisted by low-frequency ultrasound irradiation DOI Creative Commons
Junqing Lin,

Zhenhu Lin,

Leilei Liu

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101067 - 101067

Published: April 25, 2024

The blood-brain Barrier (BBB), combined with immune clearance, contributes to the low efficacy of drug delivery and suboptimal treatment outcomes in glioma. Here, we propose a novel approach that combines self-assembly mouse bone marrow-derived macrophage membrane targeted positive charge polymer (An-PEI), along low-frequency ultrasound (LFU) irradiation, achieve efficient safe therapy for Our findings demonstrate charge-induced strategy, resulting stable co-delivery nanosystem high loading efficiency 44.2%. Moreover, this structure triggers significant release temozolomide acidic environment tumor microenvironment. Additionally, coating expresses Spyproteins, which increase amount An-BMP-TMZ can evade system by 40%, while LFU irradiation facilitates opening BBB, allowing enormously increased entry (approximately 400%) into brain. Furthermore, after crossing Angiopep-2 peptide-modified exhibits ability selectively target glioma cells. These advantages result an obvious inhibition effect animal experiments significantly improve survival glioma-bearing mice. results suggest combining membrane-coated offers feasible accurate, brain disease.

Language: Английский

Citations

5
Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies DOI Creative Commons
Md. Ataur Rahman, Ehsanul Hoque Apu, S M Rakib-Uz-Zaman

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 958 - 958

Published: June 1, 2024

Autophagy is a globally conserved cellular activity that plays critical role in maintaining homeostasis through the breakdown and recycling of constituents. In recent years, there has been much emphasis given to its complex cancer stem cells (CSCs) cell treatment. This study examines molecular processes support autophagy how it regulated context CSCs Although dual management CSCs, affecting their removal as well maintenance, intricate interaction between several signaling channels control survival death part mechanism not elucidated. Given have development, progression, resistance treatment tumors, imperative comprehend biological activities. are important for biology because they also show tissue regeneration model helps with organoid regeneration. other words, manipulation viable therapeutic approach therapy. Both synthetic natural substances target pathways demonstrated promise improving cell-based therapies eliminating CSCs. Nevertheless, difficulties associated limitations CSC regulation, including mechanisms off-target effects. Thus, regulation offers versatile strategy focusing on enhancing results Therefore, understanding interactions would be essential creating treatments work both regenerative medicine

Language: Английский

Citations

3
Functionalized Nanomaterials in Cancer Treatment: A Review DOI Open Access
Óscar Gutiérrez Coronado, Cuauhtémoc Sandoval‐Salazar, José Luis Muñoz‐Carrillo

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2633 - 2633

Published: March 14, 2025

Cancer is one of the main causes death worldwide. Chemotherapy, radiotherapy and surgery are currently treatments choice for cancer. However, conventional therapies have their limitations, such as non-specificity, tumor recurrence toxicity to target cells. Recently, nanomaterials been considered therapeutic agents against This mainly due unique optical properties, biocompatibility, large surface area nanoscale size. These properties crucial they can affect biocompatibility uptake by cell, reducing efficacy. because nanoparticles be functionalized with biomolecules, become more biocompatible, which improves uptake, specifically targeted cancer cells, anticancer activity. In this review, we summarize some recent studies in aim increasing efficacy treatment.

Language: Английский

Citations

0
Nanocarriers for cutting-edge cancer immunotherapies DOI Creative Commons
Joyce Hu, Pooria Mohammadi Arvejeh,

S Bone

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 15, 2025

Cancer immunotherapy aims to harness the body's own immune system for effective and long-lasting elimination of malignant neoplastic tissues. Owing advance in understanding cancer pathology immunology, many novel strategies enhancing immunological responses against various cancers have been successfully developed, some translated into excellent clinical outcomes. As one promising strategy next generation immunotherapies, activating multi-cellular network (MCN) within tumor microenvironment (TME) deploy multiple mechanisms action (MOAs) has attracted significant attention. To achieve this effectively safely, delivering or pleiotropic therapeutic cargoes targeted sites cancerous tissues, cells, intracellular organelles is critical, which numerous nanocarriers developed leveraged. In review, we first introduce payloads categorized according their predicted functions physicochemical structures forms. Then, nanocarriers, along with unique characteristics, properties, advantages, limitations, are introduced notable recent applications immunotherapy. Following discussions on targeting strategies, a summary each nanocarrier matching suitable provided comprehensive background information designing regimens.

Language: Английский

Citations

0
Encapsulating Apigenin in Chitosan-PLGA Nanoparticles for Enhanced Breast Cancer Cytotoxicity DOI
Fatemeh Nejati, Fariba Esmaeili, Masoumeh Zahmatkeshan

et al.

Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(4)

Published: June 2, 2025

Language: Английский

Citations

0
Dual-Responsive Zwitterionic Nanogels with Synergistic Charge Reversal and Hypoxia-Activated Drug Release for Precise Tumor Targeting and Enhanced Chemotherapy DOI
Yuan Liao, Zhihao Wang,

Mengyao Guo

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114839 - 114839

Published: June 1, 2025

Language: Английский

Citations

0
Matrix metalloproteinase 2‐responsive dual‐drug‐loaded self‐assembling peptides suppress tumor growth and enhance breast cancer therapy DOI Creative Commons

Jihong Ma,

Haiyan Yang,

Xue Tian

et al.

Bioengineering & Translational Medicine, Journal Year: 2024, Volume and Issue: 9(6)

Published: July 17, 2024

Abstract Conventional chemotherapeutic agents are limited by their lack of targeting and penetration short retention time, chemotherapy might induce an immune suppressive environment. Peptide self‐assembly can result in a specific morphology, the resulting morphological changes stimuli responsive to external environment, which is important for drug permeation encapsulated agents. In this study, polypeptide (Pep1) containing peptide sequences PLGLAG RGD that matrix metalloproteinase 2 (MMP‐2) was successfully developed. Pep1 underwent transformation from spherical structure aggregates with high aspect ratio response MMP‐2 induction. This delivery system (DI/Pep1) transport doxorubicin (DOX) indomethacin (IND) simultaneously target tumor cells subsequent release while extending within cells, increases immunogenic cell death facilitates immunotherapeutic effect CD4 + T cells. Ultimately, DI/Pep1 attenuated tumor‐associated inflammation, enhanced body's response, inhibited breast cancer growth combining actions DOX IND. Our research offers approach hopefully enhance effectiveness treatment.

Language: Английский

Citations

2
Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom DOI Creative Commons
Dan Zhang,

Bingtao Zhai,

Jing Sun

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7273 - 7305

Published: July 1, 2024

Abstract: Dried toad skin (TS) and venom (TV) are the dried of Bufo bufo gargarizans Cantor melanostictus Schneider , which remove internal organs white secretions retroauricular glands. Since 2005, cinobufacini preparations have been approved by State Food Drug Administration for use as adjuvant therapies in treatment various advanced cancers. Meanwhile, bufalenolides has identified main component TS/TV, exhibiting antitumor activity, inducing apoptosis cancer cells inhibiting cell proliferation or metastasis through a variety signaling pathways. However, clinical agents frequently face limitations such inherent toxicity at high concentrations insufficient tumor targeting. Additionally, development utilization these active ingredients hindered poor water solubility, low bioavailability, rapid clearance from bloodstream. To address challenges, design targeted drug delivery system (TDDS) aims to enhance improve targeting within body, increase efficacy, reduce adverse reactions. This article reviews TDDS their components, including passive, active, stimuli-responsive TDDS, provide reference advancing use. Keywords: skin, venom, system, passive targeted,

Language: Английский

Citations

2