Dalton Transactions, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Recent advancements in ligand design and fluorophore functionalization enable Ir( iii ) photosensitizers to achieve deep-red/near-infrared absorption, addressing challenges photodynamic therapy for deep-seated tumors.
Language: Английский
Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
A series of dinuclear Ir(III) complexes have been constructed for enhanced photodynamic and photothermal therapy (PDT PTT) cisplatin-resistant non-small-cell lung cancer. They enter cells via caveolar endocytosis, target mitochondria but not nuclear, generate both singlet oxygen superoxide anion, release heat when exposed to infrared (IR) irradiation, thus inducing reactive species (ROS)-associated cell disruption thermal ablation. The IR-generated ROS can further activate caspases, triggering apoptosis. Additionally, the deplete intracellular glutathione, lead lipid peroxidation, induce ferroptosis. selected complex
Language: Английский
Citations
3
ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(9)
Published: March 1, 2025
Abstract Ruthenium complexes are gaining recognition in oncology as promising alternatives to the traditionally used platinum‐based anticancer agents. Unlike Pt agents, they can better differentiate between healthy and malignant cells, minimizing adverse side effects. They exhibit advantageous properties such thermodynamic kinetic stability, increased water solubility, enhanced cellular absorption, superior selectivity cytotoxicity for tumors, decreased toxicity cells. has been make having structural variability ability undergo ligand exchange. effective against metastatic tumor cells interact with components; their significant charges large cavities allow efficient molecule encapsulation. These being explored enhance efficacy enzymatic research targeted therapies. The manifold biochemical of ruthenium induce cell apoptosis through various signaling pathways them candidates future Despite successful testing some these clinical trials, none have commercially available. Continued aims unlock full potential cancer treatment. This review covers a few findings past 6 years on ligated organic moieties antineoplastic
Language: Английский
Citations
1
Small Methods, Journal Year: 2024, Volume and Issue: 8(11)
Published: Sept. 25, 2024
Abstract Despite the advent of various medical interventions for cancer treatment, disease continues to pose a formidable global health challenge, necessitating development new therapeutic approaches more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light activate photosensitizer produce cytotoxic reactive oxygen species (ROS) eradicating cells, has emerged as promising approach due its high spatiotemporal precision and minimal invasiveness. However, widespread clinical use PDT faces several challenges, including inefficient production ROS in hypoxic tumor microenvironment, limited penetration depth biological tissues, inadequate accumulation photosensitizers at site. Over past decade, there been increasing interest utilization photofunctional transition metal complexes applications their intriguing photophysical photochemical properties. This review provides an overview current design strategies used innovative phototherapeutics, aiming address limitations associated with achieve The challenges future perspectives on translation are also discussed.
Language: Английский
Citations
7
Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)
Published: Feb. 11, 2025
ABSTRACT Quinolines obtained from native trees of South and Central America, the genus Cinchona , have been used since 17th century for treatment malaria. However, it was only in 1820 that quinine had its structure elucidated, subsequently, during 20th century, several synthetic derivatives were produced with superior activities. In parallel, search synthesis metal complex compounds malaria dates 1994, development ferroquine, an iron derived chloroquine, developed by Biot collaborators at Lille University. After, there are complexes synthesized various metals, such as ruthenium, gold, iridium, platinum, over last 30 years, which aims this review. This review identified 84 quinoline–metal reported across 25 studies, gold (Complex 63) showing significant potency against FcBI strain (IC 50 10 nM), outperforming chloroquine (CQ, indicating coordination enhances drug's action. The ruthenium 03) exhibited activity PFB but less effective than CQ 22.5 vs. 8.2 nM). Other complexes, Au(III) 61), Ir(I) 52), Ir(II) 50), also demonstrated promising results varying effectiveness different strains. Structural features, including linear geometry Au(I) square planar or piano stool geometries Ru(II) Ir play crucial roles influencing their biological activity. These findings highlight potential improving antimalarial efficacy.
Language: Английский
Citations
0
Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 5, 2025
A new series of dinuclear Ru(II) complexes with a novel bridging ligand were developed for the treatment cisplatin-resistant non-small-cell lung cancer via synergistic photodynamic, photothermal, and sonodynamic therapy mechanism. Comprehensive experimental theoretical studies investigated their photophysical photochemical properties along influence ancillary ligands. The exhibit significant two-photon absorption at IR region, facilitating ROS generation through both type I II mechanisms under laser ultrasound exposure. They effectively target mitochondria nuclei, regulating DNA-related mechanisms, including inhibition DNA topoisomerase RNA polymerase while promoting photoactivated apoptosis ferroptosis. high synergy effect between was attributed to rise in oxygen availability ultrasound-induced cavitation thermal-induced increase vascular permeability partial pressure. In vivo experiments confirmed that combination yielded superior therapeutic outcomes compared single-modality treatments. tested complex exhibited excellent safety rapid clearance low toxicity normal cells. These findings suggest IR-activated metal can significantly advance integrated diagnostic approaches, overcoming challenges such as drug resistance hypoxic environments deep tumors.
Language: Английский
Citations
0
Small, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 11, 2024
Transition metal complex-loaded nanosystems (TMCNs) represent a cutting-edge platform for stimuli (light, ultrasound)-responsive cancer therapies. These nanosystems, incorporating metals such as manganese(II), zinc(II), ruthenium(II), rhenium(I), iridium(III), and platinum(IV), significantly enhance the efficacy of light-activated therapies, including photodynamic therapy (PDT) photothermal (PTT), well ultrasound-activated treatments like sonodynamic (SDT). TMCNs based on iridium(III) improve PDT, while manganese(II) demonstrate exceptional sonosensitizing properties. In PTT, ruthenium(II) iridium(III)-based efficiently absorb light generate heat. Emerging synergistic approaches that combine SDT, chemotherapy, immunotherapy are demonstrated to be powerful strategies precision treatment. Zinc(II), platinum(IV)-based play critical role in optimizing these enhancing tumor targeting, reducing side effects. Furthermore, can amplify by inducing immunogenic cell death, thus strengthening immune response. advances address key challenges hypoxia therapeutic resistance, opening new possibilities innovative photosensitizer-based treatments. This review highlights latest progress design applications, demonstrating their potential revolutionize stimuli-responsive
Language: Английский
Citations
1
Dalton Transactions, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Recent advancements in ligand design and fluorophore functionalization enable Ir( iii ) photosensitizers to achieve deep-red/near-infrared absorption, addressing challenges photodynamic therapy for deep-seated tumors.
Language: Английский
Citations
1