International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 314, P. 144460 - 144460
Published: May 20, 2025
Language: Английский
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 31, 2025
Mesenchymal stem cell exosomes are the most extensively researched type of Extracellular vesicles (EVs) that offer novel avenues for hair regeneration. However, their use in field regeneration was limited by poor production exosomes. It has been discovered intracellular (IVs), which produced at a higher rate than exosomes, play comparable biological purpose. As result, we developed HTMI-MN, microneedle uses tremella, Tremella polysaccharide (TPS), and hyaluronic acid (HA) as matrix materials. magnetic (Mag-IVs), work concert to treat androgenic alopecia (AGA) encourage growth. After characterization Mag-IVs, evaluated effect on angiogenesis scratch assay, Western Blot ELISA assay. In addition, tested protective Human papillary cells (HHDPCs) CCK-8 method, flow cytometry. Finally, effects tremella M1/M2 polarization macrophages were detected fluorescence staining, AGA model established vivo DHT, treatment given injection. Our study found Mag-IVs have greater power promote protect HHDPCs from apoptosis compared other vesicles. Besides, can make transformation anti-inflammatory phenotype. Taken together, experiments showed faster HTMI-MN-treated mice. These results indicate synergistically improve microenvironment, promising future treatment.
Language: Английский
Citations
1
Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)
Published: Dec. 1, 2024
ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.
Language: Английский
Citations
6
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 28, 2025
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 3, 2025
Language: Английский
Citations
0
Small Methods, Journal Year: 2025, Volume and Issue: unknown
Published: May 7, 2025
This paper introduces a novel pulsating in situ dried electrostretching (PIDES) technique for the fabrication of microneedles (MNs) transdermal drug delivery. method utilizes pulsed voltage to induce electrohydrodynamic forces that stretch and freeze polymer droplet into conical shape with micrometer-scale tip. With effects solvent evaporation, polymeric is stretched solidified, transforming sharp MN, suitable administration. Penetration mechanical tests confirm MNs possess sufficient sharpness strength effective skin penetration applications. Additionally, curcumin loading vitro release different concentrations demonstrate MNs' ability carry drugs exhibit controlled profiles. These findings highlight PIDES as promising, low-cost, simple approach development painless efficient delivery systems.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 314, P. 144460 - 144460
Published: May 20, 2025
Language: Английский
Citations
0