Ultrasound‐Responsive Aligned Piezoelectric Nanofibers Derived Hydrogel Conduits for Peripheral Nerve Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)

Published: May 15, 2024

Nerve guidance conduits (NGCs) are considered as promising treatment strategy and frontier trend for peripheral nerve regeneration, while their therapeutic outcomes limited by the lack of controllable drug delivery available physicochemical cues. Herein, novel aligned piezoelectric nanofibers derived hydrogel NGCs with ultrasound (US)-triggered electrical stimulation (ES) release repairing injury proposed. The inner layer is barium titanate nanoparticles (BTNPs)-doped polyvinylidene fluoride-trifluoroethylene [BTNPs/P(VDF-TrFE)] electrospinning improved piezoelectricity orientation. outer side thermoresponsive poly(N-isopropylacrylamide) hybrid bioactive encapsulation. Such can not only induce neuronal-oriented extension promote neurite outgrowth US-triggered wireless ES, but also realize growth factor shrinkage under heating. Thus, NGC positively accelerate functional recovery axonal regeneration rat models long sciatic defects. It believed that proposed US-responsive will find important applications in clinic neural tissue engineering.

Language: Английский

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Recent advances in the construction and application of stretchable PEDOT smart electronic membranes

Journal of Materials Chemistry C, Journal Year: 2023, Volume and Issue: 11(43), P. 14930 - 14967

Published: Jan. 1, 2023

A comprehensive overview of stretchable PEDOT membranes for smart electronics, including structures, preparation strategies and recent applications.

Language: Английский

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Growth factors: Bioactive macromolecular drugs for peripheral nerve injury treatment – Molecular mechanisms and delivery platforms

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116024 - 116024

Published: Dec. 19, 2023

Bioactive macromolecular drugs known as Growth Factors (GFs), approved by the Food and Drug Administration (FDA), have found successful application in clinical practice. They hold significant promise for addressing peripheral nerve injuries (PNIs). Peripheral guidance conduits (NGCs) loaded with GFs, context of tissue engineering, can ensure sustained efficient release these bioactive compounds. This, turn, maintains a stable, long-term, effective GF concentration essential treating damaged nerves. regeneration is complex process that entails secretion various GFs. Following PNI, GFs play pivotal role promoting cell growth survival, axon myelin sheath regeneration, differentiation, angiogenesis. also regulate regenerative microenvironment, stimulate plasticity changes post-nerve injury, and, consequently, expedite structure function repair. Both exogenous endogenous including NGF, BDNF, NT-3, GDNF, IGF-1, bFGF, VEGF, been successfully onto NGCs using techniques like physical adsorption, blend doping, chemical covalent binding, engineered transfection. These approaches effectively promoted repair Numerous studies demonstrated similar functional therapeutic outcomes compared to autologous transplantation. This evidence underscores substantial potential domain In this article, we provide an overview drug delivery systems utilizing NGCs. Looking ahead, commercial materials facilitate nerves maintain functionality distant target organs through

Language: Английский

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Multistructured hydrogel promotes nerve regeneration

Materials Today Advances, Journal Year: 2024, Volume and Issue: 21, P. 100465 - 100465

Published: Feb. 7, 2024

Hydrogels have emerged as promising biomaterials for nerve regeneration due to their adjustable properties, structural resemblance the extracellular matrix, and ability promote cell adhesion proliferation. This comprehensive review discusses advantages, challenges, future directions of various functional hydrogels. Advanced technologies fabricating Multistructured hydrogel, including injectable hydrogels, hydrogel microspheres, fibrous 3D printing nanogels, stem cell-loaded electrical ultrasound magnetic been developed studied regeneration. These demonstrate versatility hydrogels in neural tissue repair. However, challenges such biocompatibility, degradation rates, scaffold design need be addressed. Interdisciplinary research is necessary develop innovative systems that overcome these realize potential provides valuable insights into advanced highlights regenerative medicine, particularly Researchers can use this knowledge refine therapeutic approaches involving enhancing

Language: Английский

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Acoustoelectric materials & devices in biomedicine

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149314 - 149314

Published: Feb. 7, 2024

Language: Английский

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Natural Multifunctional Silk Microcarriers for Noise‐Induced Hearing Loss Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 20, 2023

Abstract Noise‐induced hearing loss (NIHL) is a common outcome of excessive reactive oxygen species in the cochlea, and targeted delivery antioxidants to inner ear potential therapeutic strategy. In this paper, novel natural biomaterials‐derived multifunctional system using silk fibroin‐polydopamine (PDA)‐composited inverse opal microcarriers (PDA@SFMCs) presented for drug NIHL therapy. Due their large specific surface area interpenetrating nanochannels, PDA@SFMCs can rapidly load active biomolecules making them convenient medium storage such molecules. addition, modification PDA enables remain round window niche, thus facilitating precise local directed loaded drugs. Based on these features, it demonstrated here that n ‐acetylcysteine‐loaded have satisfactory antioxidant properties cells successfully prevent guinea pigs. These results indicate are promising agents clinic.

Language: Английский

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Silk Fibroin-Based Triboelectric Nanogenerators for Energy Harvesting and Biomedical Applications

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(8), P. 8407 - 8423

Published: April 4, 2024

Triboelectric nanogenerators (TENGs) developed from eco-friendly natural materials rather than traditional electronic are more favorable for biocompatible applications and use in sustainable life-cycle analysis. Silk fibroin (SF) has emerged as an abundant biomaterial that shows great potential the preparation of TENGs. Silk-based triboelectric (SF-TENGs) have green energy harvesting properties, environmentally friendly, biocompatible, not fully present conventional TENGs, important next generation self-powered devices. In this review, latest progress SF-TENGs, including their applied materials, structural manufacturing processes, application scenarios, is discussed. These SF-TENGs show emerging well smart living medical assistance. addition, value been further explored, possibility main challenges expanding applying to field microneedles (MNs)

Language: Английский

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Liquid metal neuro-electrical interface

Soft Science, Journal Year: 2024, Volume and Issue: 4(3)

Published: June 11, 2024

Liquid metal (LM), an emerging functional material, plays increasing roles in biomedical and healthcare areas. It has particular values neural interfaces as it combines high conductivity, flowability, biocompatibility properties. Neuro-electrical (NEIs) are effective tools to provide a bridge between the nervous system outside world. The main target of developing is help disabled people repair damaged nerves enhance human capacity above normal ability. This article systematically summarizes LM-based interface technologies, including electrodes for electrical signal acquisition administration stimulation nerve guidance conduits connectivity reconstruction. discussion begins with overview fundamental properties associated LM materials involved field applications. fabrication methods neuro-electrodes then introduced, current development status elaborated. Finally, prospects possible challenges outlined.

Language: Английский

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Advancements in stimulation therapies for peripheral nerve regeneration

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 052008 - 052008

Published: Aug. 22, 2024

Abstract Soft-tissue injuries affecting muscles, nerves, vasculature, tendons, and ligaments often diminish the quality of life due to pain, loss function, financial burdens. Both natural healing surgical interventions can result in scarring, which potentially may impede functional recovery lead persistent pain. Scar tissue, characterized by a highly disorganized fibrotic extracellular matrix, serve as physical barrier regeneration drug delivery. While approaches such drugs, biomaterials, cells, external stimulation, other forces show promise mitigating scarring promoting regenerative healing, their implementation remains limited challenging. Ultrasound, laser, electrical, magnetic forms stimulation have been utilized promote soft tissue well neural regeneration. After tissues experience increased proliferation Schwann secretion neurotropic factors, production myelin, growth all aimed at supporting axon innervation. Yet, outcomes vary depending on pathophysiology damaged nerve, timing following injury, specific parameters employed. Increased treatment intensity duration noted hinder process inducing damage. These modalities, either alone or combination with nerve guidance conduits scaffolds, demonstrated healing. However, literature currently lacks detailed understanding used for applications. In this article, we aim address gap summarizing existing reports providing an overview alongside associated outcomes.

Language: Английский

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Flexible Neural Interface From Non‐Transient Silk Fibroin With Outstanding Conformality, Biocompatibility, and Bioelectric Conductivity

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Silk fibroin (SF) with good biocompatibility can enable an efficient and safe implementation of neural interfaces. However, it has been difficult to achieve a robust integration patterned conducting materials (multichannel electrodes) on flexible SF film substrates due the absence some enduring interactions. In this study, thermo-assisted pattern-transfer technique is demonstrated that facilely transfer layer pre-set poly(3,4-ethylenedioxythiophene) (PEDOT) onto substrate through interpenetrating network 2 polymer chains, achieving desired substrate/conductor intertwined interface flexibility (≈33 MPa), conductivity (386 S cm

Language: Английский

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