Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 213 - 228
Published: Dec. 16, 2024
Language: Английский
Nitric Oxide, Journal Year: 2024, Volume and Issue: 144, P. 20 - 28
Published: Jan. 17, 2024
Language: Английский
Citations
23
ACS Nano, Journal Year: 2024, Volume and Issue: 18(24), P. 15681 - 15694
Published: June 7, 2024
The prolonged wound-healing process caused by pathogen infection remains a major public health challenge. developed electrical antibiotic administration typically requires metal electrodes wired to continuous power supply, restricting their use beyond clinical environments. To obviate the necessity for antibiotics and an external source, we have wearable synergistic electroceutical device composed of air self-charging Zn battery. This battery integrates sustained tissue regeneration antibacterial modalities while maintaining more than half initial capacity after ten cycles chemical charging. In vitro bacterial/cell coculture with demonstrates inhibited bacterial activity enhanced cell function simulating endogenous electric field dynamically engineering microenvironment released chemicals. provides accelerated healing bacteria-infected wound stimulating angiogenesis modulating inflammation, effectively inhibiting growth at site. Considering simple structure easy operation long-term treatment, this offers great potential personalized care.
Language: Английский
Citations
10
Biomacromolecules, Journal Year: 2025, Volume and Issue: 26(1), P. 201 - 208
Published: Jan. 2, 2025
Tissue repair is often impaired in pathological states, highlighting the need for innovative wound-healing technologies. This study introduces composite hyaluronic acid gas-entrapping materials (GEMs) delivering carbon monoxide (CO) to promote wound healing pigs. These facilitate burst release followed by sustained of CO over 48 h. In a porcine full-thickness model, CO-GEMs significantly accelerated closure compared standard-of-care dressing (Tegaderm). Wound area with was 68.6% vs 56.8% on day 14, 41.0% 25.1% 28, and 26.9% 11.8% 42, effectively reducing time 14 days. Histological analysis revealed increased epithelialization neovascularization reduced inflammation. findings demonstrate potential as topical therapeutic enhance tissue clinically relevant models, supporting further testing applications.
Language: Английский
Citations
1
Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 294 - 312
Published: Feb. 20, 2025
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(31)
Published: Aug. 22, 2024
The prevalence of drug-resistant bacterial infections has emerged as a grave threat to clinical treatment and global human health, presenting one the foremost challenges in medical care. Thus, there is an urgent imperative develop safe efficacious novel antimicrobial strategies. Nitric oxide (NO) recognized endogenous signaling molecule, which plays pivotal role numerous pathological processes. Currently, NO garnered significant interest antibacterial agent due its capability eradicate bacteria, disrupt biofilms, facilitate wound healing, all while circumventing emergence drug resistance. However, inherently unstable characteristic therapeutic gas renders controlled administration gases exceedingly challenging. Hence, this review, current challenge infection discussed; then it briefly elucidated mechanism comprehensively delineate recent advancements stimulus-responsive delivery platforms, along with their merits, obstacles, prospective avenues for application. This review offers guidance future NO-medicated anti-infection therapy hoped.
Language: Английский
Citations
8
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 26, 2024
Abstract Diabetic foot ulcer typically undergoes a delayed wound‐healing process owing to the disordered microenvironment, including persistent inflammation, long‐term hypoxia, and excessive fibrosis, eventually leading severe disabilities other poor outcomes. However, current strategies cannot meet dynamic demands during process. Herein, reactive oxygen species (ROS)–responsive oxygen‐generating microneedle platform, consisting of sericin‐based glucose‐responsive hydrogel loaded with verteporfin, for effective diabetic wound healing is proposed. Under highly oxidative functionalized sericin protein depletes overproduced ROS generate oxygen, which can not only alleviate hypoxic microenvironment promote angiogenesis by activating extracellular signal‐regulated kinase Heme Oxygenase‐1 pathways but also decrease expression proinflammatory cytokines. Moreover, hyperglycaemic condition triggers gradual dissociation this platform promotes release verteporfin enhance scarless re‐epithelization via inhibiting yes‐associated signal. This versatile system integrates advantageous features inflammation alleviation, promotion, scar inhibition capabilities, accelerates repair in vivo, offers novel approach self‐supply remodeling.
Language: Английский
Citations
8
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 228 - 228
Published: Jan. 18, 2025
Promoting rapid healing is a concern in skin wound treatment, as the increased pain and loss of functional ability when wounds become chronic create complex problem to manage. This scoping review aimed explore literature synthesize existing knowledge on therapeutic use CO2 treating cutaneous wounds. The was selected using previously defined inclusion exclusion criteria, 22 articles were for data extraction. most researched type injury located extremities limbs. Carboxytherapy performed five different ways: subcutaneous, intradermal, or intralesional injections; hot water baths with temperatures ranging from 30 42 °C; transcutaneous application; intra-abdominal insufflation; paste local application. main effects therapy described follows: improved blood flow oxygenation, reduction inflammatory process, collagen production, clinical aspects wounds, faster healing. can be considered good alternative although further studies should pursued elucidate its molecular mechanisms enhance efficacy.
Language: Английский
Citations
0
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 355, P. 123424 - 123424
Published: Feb. 20, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
Gas therapy using gasotransmitters is of exponential interest due to the growing recognition gas signaling molecules that can be involved in multiple therapeutic actions. Finding suitable methods for delivering these crucial, and porous materials, notably metal-organic frameworks (MOFs), have shown exceptional potential as carriers, enabling safe controlled local delivery. The challenges translate MOF therapies clinical use require not only validate mechanisms action pathways released but also get a deep understanding into rational design, it requires combination features maximize outcomes. In this perspective, we outline key criteria designing MOFs delivery applications highlight expanding range opportunities materials may offer. Readers insights design develop gasotransmitter with realistic clinic interest.
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137401 - 137401
Published: March 1, 2025
Language: Английский
Citations
0