Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration DOI
Xiaojun Zhou, Shuo Chen, Andrij Pich

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 11(1), P. 182 - 207

Published: Dec. 12, 2024

The treatment of bone defects in diabetes mellitus (DM) patients remains a major challenge since the diabetic microenvironments significantly impede regeneration. Many abnormal factors including hyperglycemia, elevated oxidative stress, increased inflammation, imbalanced osteoimmune, and impaired vascular system microenvironment will result high rate impaired, delayed, or even nonhealing events tissue. Stimuli-responsive biomaterials that can respond to endogenous biochemical signals have emerged as effective therapeutic systems treat via combination microenvironmental regulation enhanced osteogenic capacity. Following natural healing processes, coupling angiogenesis osteogenesis by advanced bioresponsive drug delivery has proved be significant approach for promoting repair DM. In this Review, we systematically summarized mechanisms strategies DM-induced healing, outlined design systems, highlighted vascularization Accordingly, then overview recent advances developing facilitate vascularized regeneration remodeling modulating multiple regenerative cues. Furthermore, discuss development adaptable with unique features guiding DM-associated future.

Language: Английский

Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation DOI Creative Commons
Yuhui Chen, Ying Li,

H Song

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1679 - 1696

Published: Feb. 1, 2025

Background: A paramount issue in the realm of chronic wound healing among diabetic patients is pervasive inflammatory response that persistently thwarts angiogenesis, thereby precipitating protracted delays process such wounds. Employing zeolitic imidazolate framework-8 (ZIF-8) as a drug delivery platform, integrated within temperature-sensitive injectable hydrogel, presents an intriguing strategy for closure various irregular wounds, modulation responses, and promotion angiogenesis. Methods: Herein, ZIF-8 loaded with curcumin (Cur) combined methylcellulose/carboxymethyl chitosan (MCC) thermosensitive hydrogel was described. The assessment encompassed properties, pH-responsive release, antimicrobial activity, ROS scavenging capabilities MCC@ZIF-8@Cur hydrogel. series studies were conducted to explore its biocompatibility, pro-angiogenic effects, macrophage M2 polarization induction. Additionally, full-thickness skin defect model rat established investigate hydrogel's multifaceted efficacy facilitating repair, mitigating fostering Results: possess attribute being capable situ formation (gelation temperature ≥ 28 °C), establishing effective physical barrier multitude profiles. incorporation ZIF-8@Cur confers exceptional antibacterial properties capability eliminate reactive oxygen species (ROS). Moreover, continuously releases Cur Zn 2+ , inflammation, inducing macrophages, promoting This creates favorable immune microenvironment conducive regeneration, accelerating In vivo have demonstrated markedly accelerated ratio rats group compared Control ( p < 0.001). By 14th day healing, achieved remarkable 97.22%, considerably surpassing (72.98%), showcasing potential treating Conclusion: findings demonstrate successful creation exhibits capabilities. effectively suppresses modulates macrophages towards phenotype, promotes thus regeneration. These attributes collectively augur promising prospects applications Keywords: wound, microenvironment, polarization, angiogenesis

Language: Английский

Citations

3
Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications DOI

Farangis Shahi,

Hana Afshar,

Elmuez A. Dawi

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.

Language: Английский

Citations

6
Formulations with Boric Acid or Aryl-Organoboron Compounds for Treating Diabetic Foot Ulcers DOI Creative Commons
Marvin A. Soriano‐Ursúa,

Marlet Martínez‐Archundia,

Ahmet Kılıç

et al.

Scientia Pharmaceutica, Journal Year: 2025, Volume and Issue: 93(1), P. 14 - 14

Published: March 19, 2025

Boron-containing compounds (BCCs) have been proposed for the treatment of diabetes and its complications. Recent studies reported an improvement in design development pharmaceutical formulations (often gels) containing boric acid applied to foot ulcers humans diagnosed with diabetes. The mechanisms action include antimicrobial effects, modulation inflammation metabolism, induction cell differentiation. On other hand, recent suggested that boronic acids are potent antibacterial antifungal compounds, effective modulators inflammation, inducers vascular regeneration as well healing, they confer attractive properties such adhesion, interaction, formation complexes formulations. Moreover, only a handful conducted animals role some BCCs enhancers wound including their actions on induced and/or infected wounds disrupted metabolism. Also, it should be mentioned no strong interactions between present described. developed combination could act additive complementary therapy diabetic humans. Further required support hypothesis this acts through diverse improve healing while avoiding or limiting local disseminated infection. Furthermore, safety used established, these current protocols treating patients ulcers.

Language: Английский

Citations

0
Core‐Shell Structure‐Based Smart Hydrogel Wound Dressing with Endogenous and Exogenous Dual Adhesion Dynamic Response to Promote Wound Healing DOI Open Access

Shuangying Li,

Ren Li,

Xiuwen Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Abstract Herein, MIL‐88b‐NH 2 nanocage is designed with adenine inside the cage and tannins as gating outside cage. Based on this core‐shell structure, polyvinyl alcohol/carboxymethyl chitosan/MIL/adenine/tannic acid (PCMAT) hydrogels are able to respond endogenously exogenously at different stages of wound healing. The engineered hydrogel have tunable adhesion intelligence. optimal PCMAT‐0.3 reduced pore size ≈13.5 µm under endogenous response conditions, antimicrobial performance reached more than 80% within 6 h. Tensile strength strain break by 8.47% 60.52% respectively exogenous conditions. Evaluation healing effect mouse back tissue shows that rate significantly better control group without incorporation day 14. It provides an idea for development smart dressing integrates multifunctionality.

Language: Английский

Citations

0
An “all-in-one” therapeutic platform for programmed antibiosis, immunoregulation and neuroangiogenesis to accelerate diabetic wound healing DOI
Xue Yang, Lan Zhang, Jun Chen

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123293 - 123293

Published: March 1, 2025

Language: Английский

Citations

0
Microneedle-aided nanotherapeutics delivery and nanosensor intervention in advanced tissue regeneration DOI Creative Commons

Churong Xu,

Fei Wu,

Zhouyi Duan

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 3, 2025

Language: Английский

Citations

0
Engineering silk-based biomaterials: Extraction, modification, and reprocessing strategies in biomedical applications DOI Creative Commons
Zhaoyang Wang, Hạixia Chen,

Jing Yang

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 114026 - 114026

Published: May 1, 2025

Language: Английский

Citations

0
From molecular mechanisms to clinical translation: Silk fibroin-based biomaterials for next-generation wound healing DOI
Bo Liu, Yang Li,

Han Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 313, P. 144266 - 144266

Published: May 15, 2025

Language: Английский

Citations

0
Protein‐Based Multifunctional Hydrogel Adhesive for Wound Healing DOI
Kai Zhang,

Heyuan Sun,

Yuna Qian

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Abstract Wound healing is a complex and highly orchestrated biological process that encompasses four distinct stages including: hemostasis, inflammation, proliferation, remodeling. Each stage characterized by specific physiological responses tissue repair mechanisms collectively facilitate the restoration of integrity. To achieve comprehensive wound management, development targeted hydrogel bioadhesives paramount importance. Hydrogel‐based bioadhesives, their excellent physical properties biocompatibility, have demonstrated significant potential in field treatment. However, current research on protein‐based for remains limited. This review systematically examines design principles ideal essential functions repair. It provides an overview latest advancements multifunctional derived from various proteins, including collagen, silk fibroin (SF), sericin, fibrin, gelatin (Gel), keratin, casein. also evaluates performance practical applications. Finally, highlights primary challenges facing outlines prospective directions, with goal advancing clinical application these technologies.

Language: Английский

Citations

0
Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration DOI
Xiaojun Zhou, Shuo Chen, Andrij Pich

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 11(1), P. 182 - 207

Published: Dec. 12, 2024

The treatment of bone defects in diabetes mellitus (DM) patients remains a major challenge since the diabetic microenvironments significantly impede regeneration. Many abnormal factors including hyperglycemia, elevated oxidative stress, increased inflammation, imbalanced osteoimmune, and impaired vascular system microenvironment will result high rate impaired, delayed, or even nonhealing events tissue. Stimuli-responsive biomaterials that can respond to endogenous biochemical signals have emerged as effective therapeutic systems treat via combination microenvironmental regulation enhanced osteogenic capacity. Following natural healing processes, coupling angiogenesis osteogenesis by advanced bioresponsive drug delivery has proved be significant approach for promoting repair DM. In this Review, we systematically summarized mechanisms strategies DM-induced healing, outlined design systems, highlighted vascularization Accordingly, then overview recent advances developing facilitate vascularized regeneration remodeling modulating multiple regenerative cues. Furthermore, discuss development adaptable with unique features guiding DM-associated future.

Language: Английский

Citations

2