Cell Reports Physical Science, Journal Year: 2024, Volume and Issue: 5(12), P. 102318 - 102318
Published: Dec. 1, 2024
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 481, P. 136530 - 136530
Published: Nov. 15, 2024
Language: Английский
Citations
5
Small Science, Journal Year: 2024, Volume and Issue: 4(8)
Published: May 10, 2024
Nanoscale metal-organic frameworks (NMOFs) exhibit unique properties for drug delivery, including ultrahigh storage capabilities, biocompatibility, biodegradability, and sustained release of encapsulated cargo. However, due to their localized electronic states, MOFs are nonresponsive external stimuli such as light or magnetic fields. This study investigates the integration light-responsive nanoantennas into NMOFs enhance application smart delivery nanosystems. By integrating gold bipyramid within ZIF-8 NU-1000 NMOFs, core@shell nanosystems created with photothermal capabilities. Utilizing cresyl violet a model drug, loading dynamics these analyzed, demonstrating controlled under near-infrared (NIR) stimulation. Photothermal studies conducted in living cells reveal potential nanocomposites spatiotemporal targeted, light-activated delivery. Further evaluation nanocomposite loaded chemotherapeutics-doxorubicin, carboplatin, oxaliplatin-in both 2D 3D cell cultures shows nanosystem effectiveness internalization therapeutic NIR activation. The findings demonstrate that incorporation stimuli-responsive elements offers promising approach developing advanced platforms.
Language: Английский
Citations
4
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 691, P. 137462 - 137462
Published: March 30, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: April 21, 2025
Nanosized microporous metal-organic-frameworks (NMOFs) serve as versatile drug delivery systems capable of navigating complex microenvironments and interacting with cells in specific tissues. The physicochemical properties NMOFs, such size, composition, porosity, colloidal stability, external surface functionalization are essential for their success efficient carriers. This study introduces a flexible, clickable coating using an amphiphilic polymer derivatized dibenzo cyclooctyne groups universal, postsynthetic tool. To prove its universality, nanosized MOFs different structure composition (UiO-67, NU-1000, PCN-222, ZIF-8) were produced high monodispersity coated clickable, polymer. resulting polymer-coated NMOFs display exceptional structural stability biologically relevant media. For comparative purposes, we selected two size-equivalent ZIF-8 UiO-67, which functionalized library azide-derivatized (macro)molecules, including poly(ethylene glycol), mannose, dynein-binding cell-penetrating peptide, bioorthogonal reaction. choice both 150 nm size but distinct coordination chemistries, is pivotal due to differing acid base characteristics, may potentially influence performance cellular environments. track vitro, the loaded cresyl violet, common histological stain lysosomal marker. Cellular internalization surface-functionalized was markedly governed by (macro)molecule characteristics. demonstrates that critically uptake efficiency, while also highlighting versatility effectiveness proposed strategy. In particular, one peptide demonstrated higher rate compared other NMOFs. contrast, derivatizations mannose glycol) associated substantial reduction uptake, suggesting stealth behavior. These results provide alternative engineering aiming improve targeted effectiveness.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
2
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137317 - 137317
Published: Nov. 6, 2024
Language: Английский
Citations
1
Cell Reports Physical Science, Journal Year: 2024, Volume and Issue: 5(12), P. 102318 - 102318
Published: Dec. 1, 2024
Citations
1