The Influence and Mechanisms of Natural Plant Polysaccharides on Intestinal Microbiota-Mediated Metabolic Disorders DOI Creative Commons
Yong Chen, Hui Li,

Furao Lai

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3882 - 3882

Published: Nov. 30, 2024

Natural plant polysaccharides are renowned for their broad spectrum of biological activities, making them invaluable in both the pharmaceutical and food industries. Their safety, characterized by low toxicity minimal side effects, coupled with potential therapeutic properties, positions as crucial elements health-related applications. The functional effectiveness these is deeply connected to structural attributes, including molecular weight, monosaccharide components, types glycosidic bonds. These influence how interact gut microbiota, potentially alleviating various metabolic inflammatory disorders such bowel disease, diabetes, liver-associated pathologies, obesity, kidney diseases. operate through a range mechanisms. They enhance formation short-chain fatty acids, which pivotal keeping intestinal health balance. Additionally, they strengthen mucosal barrier, deterring ingress pathogens toxins into host system. By modulating immune responses within gut, help managing immune-mediated disorders, role activating specific cellular signaling pathways further underscores potential. review delves intricate structure-activity relationships natural interactions flora. understanding relationships, scientific community can develop targeted strategies use therapeutics, leading innovative treatments Furthermore, insights gained drive advancement research polysaccharide applications, providing direction novel dietary supplements foods designed support overall well-being.

Language: Английский

Targeted modulation of intestinal barrier and mucosal immune-related microbiota attenuates IgA nephropathy progression DOI Creative Commons
Ran Zhang,

Yuyan Tang,

Xiangru Feng

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 28, 2025

IgA nephropathy (IgAN) is related to the balance of gut microbiota. However, it unclear whether changes in microbiota can cause IgAN or attenuate its progression. This study employed and human microbiota-associated (HMA)-IgAN models investigate impact on alteration mechanisms by which might trigger IgAN. Furthermore, this examined effects chitooligosaccharides (COS) COS formulation (COSF) with microbiota-targeting function enhancing intestinal barrier renal functions. These results revealed that led a reduction α-diversity structural alterations microbiota, characterized an increase Shigella sonnei, Streptococcus danieliae, Desulfovibrio fairfieldensis, decrease Bifidobacterium pseudolongum Clostridium leptum. There was also imbalance B-cell immunity level tight junction proteins (ZO-1 Occludin). Intestinal mucosal immune-related (Clostridium leptum, unclassified Lachnospiraceae NK4Al36 group, Clostridia vadinBB60 Oscillospiraceae, Roseburia) were enriched through targeted modulation COS/COSF, ZO-1 expression reducing APRIL/BAFF overexpression, thereby damage In conclusion, clarified kidney-gut crosstalk between IgAN, providing scientific evidence for developing microbiota-targeted food interventions improve outcomes.

Language: Английский

Citations

2
The Influence and Mechanisms of Natural Plant Polysaccharides on Intestinal Microbiota-Mediated Metabolic Disorders DOI Creative Commons
Yong Chen, Hui Li,

Furao Lai

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3882 - 3882

Published: Nov. 30, 2024

Natural plant polysaccharides are renowned for their broad spectrum of biological activities, making them invaluable in both the pharmaceutical and food industries. Their safety, characterized by low toxicity minimal side effects, coupled with potential therapeutic properties, positions as crucial elements health-related applications. The functional effectiveness these is deeply connected to structural attributes, including molecular weight, monosaccharide components, types glycosidic bonds. These influence how interact gut microbiota, potentially alleviating various metabolic inflammatory disorders such bowel disease, diabetes, liver-associated pathologies, obesity, kidney diseases. operate through a range mechanisms. They enhance formation short-chain fatty acids, which pivotal keeping intestinal health balance. Additionally, they strengthen mucosal barrier, deterring ingress pathogens toxins into host system. By modulating immune responses within gut, help managing immune-mediated disorders, role activating specific cellular signaling pathways further underscores potential. review delves intricate structure-activity relationships natural interactions flora. understanding relationships, scientific community can develop targeted strategies use therapeutics, leading innovative treatments Furthermore, insights gained drive advancement research polysaccharide applications, providing direction novel dietary supplements foods designed support overall well-being.

Language: Английский

Citations

6