Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(9), P. 1476 - 1480
Published: March 1, 2023
A
ruthenium(II)-catalyzed
one-pot
synthesis
of
highly
substituted
1,2-dihydropyridines
(DHPs)
via
a
three-component
reaction
system
has
been
realized.
The
is
conducted
using
simple
Ru(II)
catalyst
without
the
addition
specific
ligands.
catalytic
exhibits
good
functionality
tolerance
with
wide
range
starting
materials.
DHPs
obtained
can
be
easily
converted
into
tetrahydropyridines
and
azabicyclo[4.2.0]octa-4,7-dienes
by
subsequent
reduction
or
[2
+
2]
cycloaddition
reaction.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(43), P. 5626 - 5629
Published: Jan. 1, 2024
Isoquinolones
undergo
efficient
Co(
iii
)-catalyzed
C8-allylation
and
vinylation,
utilizing
the
oxo
group
of
isoquinolones
as
an
inherent
directing
group.
The
resulting
allylated
vinylated
are
further
transformed
into
important
building
blocks.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
provides
an
overview
of
the
research
advaces
in
Ni-,
Cu-,
Fe-
and
Co-catalyzed
directed
C(sp
3
)–H
bond
functionalization
reactions;
including
design
principles,
mechanistic
discussions,
along
with
potential
applications
limitations.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(10), P. 2091 - 2096
Published: March 5, 2024
Herein,
we
report
the
facile
synthesis
of
indole
C(4)-acrylophenone
using
a
C–H
bond
activation
strategy.
For
this
conversion,
an
unsymmetrical
alkyne
(phenylethynyl
ether)
in
presence
cobalt(III)-catalyst
works
efficiently.
In
process,
gets
oxidized
situ
generated
water,
which
is
key
step
for
method,
trifluoroethanol
water
source.
The
pivaloyl
directing
group
chelates
effectively
to
generate
cobaltacycle
intermediate,
was
detected
through
high-resolution
mass
spectrometry
(HRMS).
Also,
formation
bis(2,2,2-trifluoroethyl)
ether
has
been
confirmed
and
quantified
19F
NMR.
addition,
applicability
obtained
product
demonstrated
by
performing
Nazarov
cyclization
conjugate
addition
α,β-unsaturated
ketone
moiety.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(22), P. 4390 - 4419
Published: Jan. 1, 2024
The
merger
of
organic
electrosynthesis
with
3d
transition-metal
catalysis
has
offered
huge
opportunities
for
modern
synthesis.
This
review
summarizes
the
key
advancements
in
this
direction
published
recent
two
years.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(30)
Published: June 15, 2023
Abstract
An
efficient
Rh(III)‐catalyzed
C−H
alkenylation
of
N
‐protected
isoquinolone
with
maleimides
is
reported.
The
carbonyl
group
acts
as
an
inherent
directing
group.
Various
‐substituents
in
the
maleimide,
including
alkyl,
aryl,
and
even
H
−OH,
were
well
tolerated
under
developed
reaction
condition.
This
protocol
showed
broad
substrate
scope,
good
selectivity,
excellent
yields.
Hammett
plot
also
drawn
to
check
effect
substituents
on
progress.
