Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(7)
Published: May 23, 2023
Abstract
The
Povarov
reaction
is
a
representative
multicomponent
used
for
synthesizing
nitrogen‐containing
aromatic
compounds
from
amines,
aldehydes,
and
dienophiles,
such
as
electron‐rich
alkenes
alkynes.
In
this
study,
we
investigated
triple
of
1,3,5‐triaminobenzne
with
aldehydes
phenylacetylene
to
obtain
triazatriphenylene
derivatives.
Reactions
arylaldehydes
containing
electron‐donating
groups
proceeded
smoothly
provide
contrast,
reactions
electron‐withdrawing
resulted
in
low
yields.
are
probably
more
favorable
terms
high
stability
imine
intermediates
smooth
electrophilic
cyclization.
Single‐crystal
X‐ray
structure
analysis
revealed
that
the
aryl
derived
had
small
dihedral
angles
between
core.
derivative
tertiary
butyl
(
tBu‐TaT
)
glass
transition
temperature,
while
without
H‐TaT
lower
highest
occupied
molecular
orbital
(HOMO)
lowest
unoccupied
(LUMO)
level
served
an
efficient
hole‐blocking
material
better
electron
transport
properties
than
those
.
This
study
provides
insights
into
scope
limitations
based
on
reaction,
substituent
dependence
crystal
structures,
physical
π‐extended
compounds.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(11), P. 7188 - 7198
Published: May 12, 2023
Rongalite
has
been
used
as
a
cheap
and
efficient
carbon
synthon
for
the
synthesis
of
divergent
N-heteroaromatics,
including
different
pyridines
quinolines.
The
selective
products
can
be
achieved
by
employing
enaminones
or
enaminones/anilines
reaction
partners.
In
addition,
compared
with
using
conventional
aldehyde
synthons,
rongalite
displays
an
evident
advantage
in
providing
considerably
higher
product
yields
under
milder
conditions.
GC-MS
analysis
process
performed
to
probe
possible
mechanism.
The Chemical Record,
Journal Year:
2023,
Volume and Issue:
23(12)
Published: Nov. 27, 2023
Cancer
stands
as
a
serious
malady,
posing
substantial
risks
to
human
well-being
and
survival.
This
underscores
the
paramount
necessity
explore
investigate
novel
antitumor
medications.
Nitrogen-containing
compounds,
especially
those
derived
from
natural
sources,
form
highly
significant
category
of
agents.
Among
these,
agents
with
six-membered
aromatic
nitrogen
heterocycles
have
consistently
attracted
attention
chemists
pharmacologists.
Accordingly,
we
present
comprehensive
summary
synthetic
strategies
clinical
implications
these
compounds
in
this
review.
entails
an
in-depth
analysis
synthesis
pathways
for
pyridine,
quinoline,
pyrimidine,
quinazoline.
Additionally,
historical
progression,
targets,
mechanisms
action,
effectiveness
small
molecule
inhibitors
possessing
structural
features.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(9), P. 2607 - 2612
Published: Jan. 1, 2024
A
metal-free,
scalable,
and
cascade
protocol
for
assembling
diverse
polysubstituted
pyridines
from
tertiary
enaminones
α,β-unsaturated
sulfonylketimines
by
cleaving
C–N/N–S
bonds
is
reported.
Chinese Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 7, 2025
Comprehensive
Summary
Herein,
we
have
developed
a
facile
method
for
the
synthesis
of
various
polysubstituted
pyridine
derivatives
through
selective
6π‐electrocyclization
N
‐vinyl‐
α
,
β
‐unsaturated
nitrones.
It
was
found
that
gold
catalysts
promoted
carbon‐6π‐electrocyclization
nitrones
to
afford
6‐alkenyl
‐oxides
in
43%—75%
yields,
whereas
copper
facilitated
oxygen‐6π‐electrocyclization
give
6‐epoxy
pyridines
41%—83%
yields.
The
present
features
broad
substrate
scope,
good
functional
group
tolerance,
high
cyclization
selectivity,
and
diversity
scaffolds.
Organic Syntheses,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 25
Published: Aug. 1, 2024
Abstract
This
chapter
presents
the
procedure
for
preparation
of
highly‐substituted
pyridines
via
Diels‐Alder
reactions
vinylallenes
and
tosyl
cyanid.
The
procedures
in
Organic
Syntheses
are
intended
use
only
by
persons
with
proper
training
experimental
organic
chemistry.
All
hazardous
materials
should
be
handled
using
standard
work
chemicals
described
references
such
as
“Prudent
Practices
Laboratory”.
development
practical
efficient
methods
construction
highly
substituted
remains
a
challenging
goal
synthesis.
Vinylallenes
reactive
dienes
which
engage
cycloadditions
triple
bonds
to
afford
isoaromatic
products
that
isomerize
aromatic
systems
spontaneously
or
under
mild
conditions.
authors
have
developed
several
strategies
synthesis
based
on
nitrogen
heterodienophiles.
also
describes
optimal
conditions
reaction
vinylallene
2
cyanide.
Chemistry Letters,
Journal Year:
2023,
Volume and Issue:
52(3), P. 148 - 151
Published: Jan. 25, 2023
The
one-pot
synthesis
of
substituted
pyridines
from
alkyl
ketones,
Stork
enamines,
and
ammonia
is
reported.
This
reaction
involves
the
nickel-catalyzed
dehydrogenation
ketone
conjugate
addition
enamine,
followed
by
condensation
with
an
ammonium
salt
to
yield
corresponding
pyridine.
Furthermore,
α-alkylation
δ-amino-γ,δ-unsaturated
intermediates
leads
tetrasubstituted
pyridine
in
excellent
yields
means
a
three-step
reaction.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
This
study
describes
a
general
method
for
the
preparation
of
1,4-oxazin-2-one
intermediates
from
acetylene
dicarboxylate
and
β-amino
alcohol
precursors.
Oxazinones
prepared
in
this
manner
were
employed
tandem
cycloaddition/cycloreversion
reaction
sequence
with
model
alkyne
(phenyl
acetylene)
to
give
substituted
pyridine
products.
Fundamental
reactivity
selectivity
studies
are
complemented
by
synthesis
polycyclic
ergot
alkaloid
natural
product
xylanigripone
A.
