Iron(III)-Catalyzed Amine-Release Triple Condensation of Enaminones to C3-Alkenylated Dihydroquinolinones DOI
Qiaoqiao Wang, Yuan Xu, Haoyang Sun

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(15), P. 10538 - 10550

Published: July 12, 2024

C3-functionalized dihydroquinolinones represent a class of important biologically active compounds. Although methods for synthesizing C2/4-functionalized have been extensively reported, research on the synthesis dihydroquinolinone is extremely rare. Herein, we report first time method C3-alkenylated via iron(III)-catalyzed amine-release triple condensation enaminones. These reactions exhibit broad substrate scope and offer operationally simple, low-cost catalyzed procedures in single step. Subsequent intramolecular intermolecular additions to alkene moiety provide diverse derivatives.

Language: Английский

Facile synthesis of the unknown 6,7-dihydrofuro[3,4-c]pyridines and 3,4-diaryloylpyridines from N-propargyl β-enaminones DOI Creative Commons
Elif Serel Yilmaz, Kerem Kaya, Metin Zora

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A simple methodology for the synthesis of bicyclic 6,7-dihydrofuro[3,4- c ]pyridines is reported. The skeletal diversity synthesized heterobicyclic frame may present new nitrogen- and oxygen-based hybrid systems medicinal chemistry.

Language: Английский

Citations

0
Mechanosynthesis of polysubstituted pyridines via FeBr3-catalyzed cascade reaction of arylidene isoxazolones with β‑carbonyl esters DOI
Lei Wang, Mingjun Li, Qinghai Li

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155569 - 155569

Published: March 1, 2025

Language: Английский

Citations

0
Rhodium(III)-Catalyzed Sequential Cyclization of Enaminones with 1,3-Dienes via C–H Activation for the Synthesis of Fluorenones DOI
Lei Gao, Min Wang,

Hongwei Ren

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

An efficient method for construction of various fluorenones has been achieved via Rh(III)-catalyzed C–H activation/[4 + 2] annulation/aromatization sequences simple and readily available enaminones 1,3-dienes. This protocol showed good substrate compatibility as an array structurally electronically diverse prepared efficiently in moderate to yields preparative scale utility showing very efficiency the late-stage functionalization complex valuable molecules.

Language: Английский

Citations

3
Iron(III)-Catalyzed Amine-Release Triple Condensation of Enaminones to C3-Alkenylated Dihydroquinolinones DOI
Qiaoqiao Wang, Yuan Xu, Haoyang Sun

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(15), P. 10538 - 10550

Published: July 12, 2024

C3-functionalized dihydroquinolinones represent a class of important biologically active compounds. Although methods for synthesizing C2/4-functionalized have been extensively reported, research on the synthesis dihydroquinolinone is extremely rare. Herein, we report first time method C3-alkenylated via iron(III)-catalyzed amine-release triple condensation enaminones. These reactions exhibit broad substrate scope and offer operationally simple, low-cost catalyzed procedures in single step. Subsequent intramolecular intermolecular additions to alkene moiety provide diverse derivatives.

Language: Английский

Citations

2