Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
31(8)
Published: Nov. 25, 2024
Abstract
We
report
the
development
of
an
azanide
(
−
NH
2
)
surrogate
which
enables
facile
conversion
electron‐deficient
(hetero)aryl
halides
into
primary
N
‐aryl
amines
under
transition‐metal‐free
conditions.
The
designed
amidine
reagent
is
easy
to
prepare,
bench
stable,
and
undergoes
‐arylation
basic
conditions
at
40
°C.
Intermediate
amidines
are
readily
cleaved
form
in
situ
through
hydrolysis
or
base‐promoted
elimination.
developed
a
safer
more
selective
alternative
existing
anionic
N‐nucleophiles,
such
as
alkali
metal
amides
azide
salts.
Synthesis,
Journal Year:
2023,
Volume and Issue:
56(02), P. 229 - 238
Published: July 20, 2023
Abstract
Transition-metal
catalysis
has
been
consequential
in
enabling
carbon–heteroatom
bond-forming
reactions.
Recent
breakthroughs
Ni-catalyzed
cross-couplings
have
offered
competitive
and,
some
cases,
superior
reactivity
to
Pd-
or
Cu-based
processes.
Amidst
the
ongoing
renaissance
this
field,
C–O
cross-coupling
of
alcohols
and
(hetero)aryl
(pseudo)halides
surfaced
as
an
effective
strategy
for
synthesis
ethers.
Methodologies
achieve
such
transformations
tend
rely
on
one
three
catalytic
approaches:
(i)
thermal
conditions
often
accompanied
by
ancillary
ligand
design
tailored
Ni
catalysis;
(ii)
synergistic
combination
photoredox
(iii)
electrochemically
driven
catalysis.
In
instances,
these
protocols
provided
access
expanded
substrate
scope,
including
use
inexpensive
abundant
electrophile
coupling
partners
(e.g.,
chlorides).
This
Short
Review
aims
summarize
recent
progress
development
O-arylations
primary,
secondary,
tertiary
aliphatic
alcohols,
well
phenols,
with
electrophiles.
1
Introduction
2
Thermally
Promoted
Cross-Coupling
2.1
Primary
Secondary
Aliphatic
Alcohols
2.2
Tertiary
2.3
Phenols
3
Photochemically
3.1
3.2
4
Electrochemically
4.1
5
Conclusions
Outlook
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(30)
Published: Aug. 6, 2024
Abstract
tert‐
Butyl
hydroperoxide
(tBuOOH,
TBHP)
is
a
commonly
used
in
many
oxidation
processes.
The
primary
factors
contributing
to
the
increasing
usefulness
of
TBHP
include
its
affordability,
eco‐friendliness,
exceptional
efficacy,
and
capacity
substitute
harmful
or
rare
heavy
metal
oxidants.
In
this
sexennial
update,
we
thoroughly
critically
examined
most
noteworthy
applications
C−H
functionalization
heteroatom‐heteroatom
bond
formation
reactions
from
2018
till
present.
review
has
been
subdivided
based
on
nature
bonds
being
formed.
focuses
advantages
disadvantages
using
synthetic
organic
transformations,
as
well
breadth
their
use
underlying
mechanisms
involved.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(6), P. 1782 - 1789
Published: Jan. 1, 2024
An
organocatalytic
domino
reaction
of
β-alkyl
nitroolefins
with
alkylidene
malononitriles
to
give
azetidine
nitrones
good
diastereoselectivities
is
reported.
The
in
situ
-generated
were
transmuted
into
isoxazoles
catalyzed
by
acid.
Chemistry - An Asian Journal,
Journal Year:
2024,
Volume and Issue:
19(11)
Published: April 8, 2024
Abstract
(C−X)
bonds
(X=C,
N,
O)
are
the
main
backbone
for
making
different
skeleton
in
organic
synthetic
transformations.
Among
all
sustainable
techniques,
electro‐organic
synthesis
C−X
bond
formation
is
advanced
tool
as
it
offers
a
greener
and
more
cost‐effective
approach
to
chemical
reactions
by
utilizing
electrons
reagents.
In
this
review,
we
want
explore
recent
advancements
electrochemical
C−O
formation.
The
electrochemically
driven
represents
an
emerging
exciting
area
of
research.
context,
techniques
numerous
advantages,
including
higher
yields,
cost‐efficient
production,
simplified
work‐up
procedures.
This
method
enables
continuous
consistent
molecules,
significantly
enhancing
overall
reaction
yields.
Furthermore,
both
intramolecular
intermolecular
forming
provided
valuable
products
O‐containing
acyclic/cyclic
analogue.
Hence,
carbonyl
(C=O),
ether
‐O‐),
ester
(‐COOR)
functionalization
cyclic/acyclic
analogues
have
been
prepared
continuously
via
innovative
pathway.
discuss
one‐decade
pathways
various
contains
functional
group
chronological
manner.
review
focused
on
aspects
mechanistic
path
has
also
mentioned
critical
finding
regarding
pathways.
Open Life Sciences,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Jan. 1, 2024
Neuroinflammation,
characterized
by
microglial
activation
and
the
subsequent
secretion
of
inflammatory
cytokines,
plays
a
pivotal
role
in
neurodegenerative
diseases
brain
injuries,
often
leading
to
neuronal
damage
death.
Alleviating
neuroinflammation
has
thus
emerged
as
promising
strategy
protect
neurons
ameliorate
disorders.
While
peroxisome
proliferator-activated
receptor
gamma
(PPARγ)
agonists
have
demonstrated
potential
therapeutic
actions
on
neuroinflammation,
their
prolonged
use,
such
with
rosiglitazone,
can
lead
cardiac
risks
lipid
differentiation
In
this
study,
we
investigated
effects
newly
synthesized
PPARγ
agonist,
VSP-2,
cytokines
BV2
cells.
Treatment
VSP-2
significantly
reduced
mRNA
protein
levels
proinflammatory
interleukin-1β
(IL-1β),
IL-6,
tumor
necrosis
factor-α
(TNF-α).
Furthermore,
attenuated
phosphorylation
nuclear
factor
kappa
B
(NF-κB)
(65
kD)
IκBα,
well
translocation
NF-κB
kD).
Additionally,
use
small
interfering
RNA
was
able
attenuate
pathway.
conclusion,
our
findings
suggest
that
effectively
suppressed
expressions
IL-1β,
TNF-α
via
PPARγ/NF-κB
signaling
Given
its
benefits,
may
emerge
candidate
for
treatment
or
injuries
associated
neuroinflammation.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(19)
Published: May 15, 2024
Abstract
The
transition‐metal‐free
synthesis
of
organic
compounds
especially
heterocycles
is
in
resonance
with
one
the
twelve
principles
proposed
by
Prof.
Paul
Anastas
his
renowned
work
towards
sustainable
development
green
chemistry.
Traditional‐metal‐catalyzed
reactions
often
involve
expensive
or
toxic
metal
catalysts,
and
there
a
growing
interest
developing
more
environmentally
friendly
methods.
arylation
an
important
area
research
chemistry,
particularly
biologically
active
pharmaceuticals.
Arylation
at
different
positions
enhances
potency
stability
pharmaceutically
scaffolds.
In
this
review,
overview
synthetic
protocols
developed
for
variety
heterocyclic
including,
pyrroles,
pyridines,
thiophene,
indole,
oxindoles,
purines,
xanthene,
etc.
has
been
described.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 19, 2024
Abstract
Pyrazoles
and
pyrazolo
fused
pyrimidines
pyridines
are
well
known
for
their
applications
in
various
fields
like
pharmaceuticals,
agrochemicals
materials
sciences.
Keeping
this
mind
herein,
we
have
developed
the
transition‐metal‐free
approach
chemo‐selective
synthesis
of
pyrazole
its
derivatives
from
acetopheneones.
The
selectivity
reaction
can
easily
be
tuned
by
shifting
acidic
to
basic
medium
pyrazolo‐pyrirmidines
pyrazolo‐pyridines
respectively.
shows
excellent
functional
group
tolerance
form
−F,
−Cl,
−Br,
−NMe
2
,
−OH,
−OMe,
−B(OH)
good
yields.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(14)
Published: May 31, 2023
Alkoxylation
of
benzylic
C(sp3
)-H
bonds
has
become
one
the
most
important
tools
for
construction
benzyl
ethers
from
feedstock
chemicals.
Herein,
we
reported
a
silver
catalyzed
alkoxylation
employing
potassium
persulfate
as
an
oxidant
at
room
temperature.
This
strategy
showed
good
functional-group
tolerance,
site
selectivity,
and
chemoselectivity.
The
reaction
proceeded
smoothly
in
presence
various
primary,
secondary,
tertiary
alcohol
nucleophiles,
affording
corresponding
ethers.
Combined
experimental
studies
provided
mechanistic
insights
into
possible
radical
pathways.
Furthermore,
mechanism
was
proposed
this
method.
