Optimum Doses and Forms of Selenium Maintaining Reproductive Health via Regulating Homeostasis of Gut Microbiota and Testicular Redox, Inflammation, Cell Proliferation, and Apoptosis in Roosters

Journal of Nutrition, Journal Year: 2023, Volume and Issue: 154(2), P. 369 - 380

Published: Dec. 19, 2023

Language: Английский

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Protective effects of naringin on colistin‐induced damage in rat testicular tissue: Modulating the levels of Nrf‐2/HO‐1, AKT‐2/FOXO1A, Bax/Bcl2/Caspase‐3, and Beclin‐1/LC3A/LC3B signaling pathways

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(2)

Published: Jan. 21, 2024

Abstract Antimicrobial agent resistance has become a growing health issue across the world. Colistin (COL) is one of drugs used in treatment multidrug‐resistant bacteria resulting toxic effects. Naringin (NRG), natural flavonoid, come to fore as its antioxidant, anti‐inflammatory, and antiapoptotic activities. The aim present study was determine whether NRG protective effects on COL‐induced toxicity testicular tissue. Thirty‐five male Spraque rats were randomly divided into five groups ( n = 7 per group): Control, COL, NRG, COL + 50, 100. (15 mg/kg b.w., i.p., once per/day), (50 or 100 mg/kg, oral, b.w./once per/day) administered for days. parameters oxidative stress, inflammation, apoptosis, autophagic damage evaluated by using biochemical, molecular, western blot, histological methods issues. reversed increased malondialdehyde level reduced antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione) levels due administration p < 0.001), stress mitigated. Nuclear factor erythroid 2‐related factor‐2 pathway, antioxidant defence systems, stimulated 0.001). markers pathways apoptotic 0.001) damages induced COL. Sperm viability live/dead ratio but enhanced treatment. Testicular tissue integrity damaged showed tendency improve NRG. In conclusion, exhibited effect elevating autophagy, damage. demonstrated alleviating

Language: Английский

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The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 190, P. 114791 - 114791

Published: June 6, 2024

Language: Английский

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Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(7)

Published: June 16, 2024

Paclitaxel (PTX), which is actively used in the treatment of many types cancer, has a toxic effect by causing increased oxidative stress testicular tissues. Naringin (NRG) natural flavonoid found plants, and its antioxidant properties are at forefront. This study aims to investigate protective feature NRG PTX-induced toxicity. Thirty-five male Sprague rats were divided into five groups: control, NRG, PTX, PTX + NRG50, NRG100. Rats administered (2 mg/kg, BW) intraperitoneally once daily for first 5 days. Then, between 6th 14th days, (50 100 mg/kg) was orally day. reduced lipid peroxidation tissue capacity (superoxide dismutase, catalase, glutathione peroxidase, glutathione). While reduces mRNA expression levels nuclear factor kappa B, tumor necrosis factor-alpha, interleukin-1 beta, cyclooxygenase-2, interleukin-6, inducible-nitric oxide synthase, mitogen-activated protein kinase 14 (MAPK)14, MAPK15, c-Jun N-terminal kinase, P53, Apaf1, Caspase3, Caspase6, Caspase9, Bax tissues; it caused an increase Nrf2, HO-1, NQO1 Bcl-2 levels. also improved structural functional integrity disrupted PTX. sperm damage alleviated NRG. showed alleviating toxicity increasing stress, inflammation, apoptosis, autophagy.

Language: Английский

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The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 pathways

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(10)

Published: Sept. 24, 2024

Arsenic is a toxic environmental pollutant heavy metal, and one of its critical target tissues in the body liver. Carvacrol natural phytocompound that stands out with antioxidant, anti-inflammatory, antiapoptotic properties. The current study aims to investigate protective feature carvacrol against sodium arsenite-induced liver toxicity. Thirty-five Sprague-Dawley male rats were divided into five groups: Control, Sodium arsenite (SA), CRV, SA + CRV25, CRV50. was administered via oral gavage at dose 10 mg/kg for 14 days, 30 min later, CRV 25 or 50 gavage. Oxidative stress, inflammation, apoptosis, autophagy damage pathways parameters, tissue integrity analyzed using biochemical, molecular, western blot, histological, immunohistological methods. decreased oxidative stress by suppressing malondialdehyde levels increasing superoxide dismutase, catalase, glutathione peroxidase activities, levels. reduced inflammation reducing increased NF-κB cytokines (TNF-α, IL-1β, IL-6, RAGE, NLRP3) it stimulates. also autophagic (Beclin-1, LC3A, LC3B) apoptotic (P53, Apaf-1, Casp-3, Casp-6, Casp-9, Bax) parameters. preserved impaired structure. alleviated increases parameters rat tissues. beneficial preserving integrity.

Language: Английский

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Composition of Whole Grain Dietary Fiber and Phenolics and Their Impact on Markers of Inflammation

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1047 - 1047

Published: April 3, 2024

Inflammation is an important biological response to any tissue injury. The immune system responds stimulus, such as irritation, damage, or infection, by releasing pro-inflammatory cytokines. overproduction of cytokines can lead several diseases, e.g., cardiovascular joint disorders, cancer, and allergies. Emerging science suggests that whole grains may lower the markers inflammation. Whole are a significant source dietary fiber phenolic acids, which have inverse association with risk Both cereals pseudo-cereals rich in fiber, arabinoxylan β-glucan, hydroxycinnamic acids hydroxybenzoic predominantly present bran layer. However, mechanisms underlying widely reported between grain consumption disease not fully understood. modulatory effects on inflammation likely be influenced including effect acids. While some these direct, others involve gut microbiota, transforms bioactive substances into more beneficial metabolites modulate inflammatory signaling pathways. Therefore, purpose this review twofold: first, it discusses highlights their potential; second, examines health benefits components impacts subclinical markers, role microbiota. Overall, while there promising evidence for anti-inflammatory properties grains, further research needed understand fully.

Language: Английский

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Protective Effects of Syringic Acid Against Oxidative Damage, Apoptosis, Autophagy, Inflammation, Testicular Histopathologic Disorders, and Impaired Sperm Quality in the Testicular Tissue of Rats Induced by Mercuric Chloride

Environmental Toxicology, Journal Year: 2024, Volume and Issue: 39(10), P. 4803 - 4814

Published: Aug. 3, 2024

Mercury (Hg) is one of the most toxic heavy metals that damage testicular tissue. chloride (HgCl

Language: Английский

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Ameliorative effects of sinapic acid against vancomycin-induced testicular oxidative damage, apoptosis, inflammation, testicular histopathologic disorders and decreased epididymal sperm quality

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 129, P. 108666 - 108666

Published: July 25, 2024

Language: Английский

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Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 14, 2025

Abstract Background Lead (Pb) is a heavy metal with extreme toxicity and numerous industrial uses. It produces nephrotoxicity notable changes in renal architecture function. The Alhagi maurorum (AM) belongs to the family Fabaceae native Middle East area. In present study, potential nephroprotective effects of AM Pb-intoxicated rats were evaluated. Results methanolic extract was standardized reference its main phenolic compounds orientin, rutin, quercetin. Acute oral studies indicated that safe for animals. Rats allocated into five groups treated 28 days as follows: control, (200 mg/kg, orally), Pb (15 + (100 mg/kg), mg/kg). administration markedly increased serum cystatin C, urea, creatinine levels, urinary NAG. also caused histopathological alterations. However, o-treatment ameliorated such pathological changes. addition, treatment prevented Pb-induced accumulation malondialdehyde (MDA), attenuated glutathione (GSH) depletion, catalase (CAT) superoxide dismutase (SOD) exhaustion. guarded against enhanced protein expression interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), cyclooxygenase-2 (COX-2), nuclear factor-kappa B (NF-κB). Further, significantly upregulation mRNA levels Bax downregulation Bcl-2. These associated heme oxygenase-1 (HO-1) factor erythroid 2-related 2 (Nrf2) tissue. Conclusion guards involve, at least partly, antioxidant, anti-inflammatory, anti-apoptotic activities well modulation HO-1 Nrf2 expression.

Language: Английский

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Effects of Morin on the Wnt, Notch1/Hes1, KI-67/3-Nitrotyrosine and Damage Signaling Pathways in Rats Subjected to Experimental Testicular Ischemia/Reperfusion

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract Aim Testicular torsion, which occurs when the testicle rotates around axis of spermatic cord, is a serious cause hospital admission, mostly in newborns and children, but also adults. Oxidative stress an important mediator development complications. Morin has anti-inflammatory, anti-autophagic, anti-apoptotic activities especially strong antioxidant activity. This study aimed to determine effects on testicular torsion injury. Methods 35 Wistar rats were divided into 5 groups (n = 7): Control, Morin, I/R, I/R + MRN50, MRN100. Parameters are effective oxidative stress, inflammation, endoplasmic reticulum apoptosis, autophagy damage Wnt pathway parameters, KI-67, 3-NT levels analyzed by biochemical, molecular, histological methods. Results injury significantly increased (MDA, p < 0.001) reduced activity (GSH, SOD, CAT, GPx; 0.001). MRN administration reversed these effects, with higher doses showing greater improvement (p 0.01 for 0.001 others). Inflammation markers (NF-kB, IL-1β, TNF-α, COX-2, iNOS) elevated group, their expression mitigated ER reactivated signaling pathway, particularly at 100 mg/kg Additionally, apoptosis (Caspase-3, Bax, (Beclin-1, LC3A, LC3B, 0.001), improved histology sperm parameters. treatment restored density, motility, viability 0.05), proving more effective. Conclusion properties inhibiting many pathways activating protective mechanisms.

Language: Английский

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