Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(29)
Published: Feb. 13, 2024
Abstract
Defect
engineering
is
an
emerging
technology
for
tailoring
nanomaterials'
characteristics
and
catalytic
performance
in
various
applications.
Recently,
defect‐engineered
nanoparticles
have
emerged
as
highly
researched
materials
applications
because
of
their
exceptional
redox
reaction
capabilities
physicochemical
optical
properties.
The
properties
nanomaterials
can
be
readily
adjusted
by
controlling
the
nature
concentration
defects
within
nanoparticles,
avoiding
need
intricate
design
strategies.
This
review
investigates
defect
nanocatalysts,
including
design,
fabrication,
Initially,
categories
strategies
nanomaterial
impacts
on
nanocatalysts'
electronic
surface
properties,
activity,
selectivity,
stability
are
summarized.
Then,
processes
uses,
gas
sensing,
hydrogen
(H
2
)
evolutions,
water
splitting,
reductions
carbon
dioxide
(CO
nitrogen
to
value‐aided
products,
pollutant
degradation,
biomedical
(oncotherapy,
antibacterial
wound
healing,
biomolecular
sensing)
discussed.
Finally,
limitations
prospective
paths
allowing
logical
optimization
nanocatalytic
long‐term
efficient
also
examined.
comprehensive
gives
unique
insights
into
current
state
nanocatalysts
inspires
future
research
exploiting
shortcomings
improve
customize
performance.
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 14, 2024
Abstract
Ferroptosis
is
a
new
form
of
regulated
cell
death
featuring
iron‐dependent
lipid
peroxides
accumulation
to
kill
tumor
cells.
A
growing
body
evidence
has
shown
the
potential
ferroptosis‐based
cancer
therapy
in
eradicating
refractory
malignancies
that
are
resistant
apoptosis‐based
conventional
therapies.
In
recent
years,
studies
have
reported
number
ferroptosis
inducers
can
increase
vulnerability
cells
by
regulating
ferroptosis‐related
signaling
pathways.
Encouraged
rapid
development
ferroptosis‐driven
therapies,
interdisciplinary
fields
combine
ferroptosis,
pharmaceutical
chemistry,
and
nanotechnology
focused.
First,
prerequisites
metabolic
pathways
for
briefly
introduced.
Then,
detail
emerging
designed
boost
ferroptosis‐induced
therapy,
including
metal
complexes,
metal‐based
nanoparticles,
metal‐free
nanoparticles
summarized.
Subsequently,
application
synergistic
strategies
with
apoptosis
other
emphasis
on
use
both
cuproptosis
induce
redox
dysregulation
intracellular
bimetallic
copper/iron
metabolism
disorders
during
treatment
discussed.
Finally,
challenges
associated
clinical
translation
future
directions
potentiating
therapies
highlighted.
Small,
Journal Year:
2024,
Volume and Issue:
20(30)
Published: March 5, 2024
Abstract
Gene
therapy
uses
modern
molecular
biology
methods
to
repair
disease‐causing
genes.
As
a
burgeoning
therapeutic,
it
has
been
widely
applied
for
cancer
therapy.
Since
1989,
there
have
numerous
clinical
gene
cases
worldwide.
However,
few
are
successful.
The
main
challenge
of
is
the
lack
efficient
and
safe
vectors.
Although
viral
vectors
show
high
transfection
efficiency,
their
application
still
limited
by
immune
rejection
packaging
capacity.
Therefore,
development
non‐viral
overwhelming.
Nanoplatform‐based
become
hotspot
in
reasons
mainly
as
follows.
1)
Non‐viral
can
be
engineered
uptaken
specific
types
cells
or
tissues,
providing
effective
targeting
capability.
2)
protect
goods
that
need
delivered
from
degradation.
3)
Nanoparticles
transport
large‐sized
cargo
such
CRISPR/Cas9
plasmids
nucleoprotein
complexes.
4)
highly
biosafe,
they
not
mutagenic
themselves
compared
5)
easy
scale
preparation,
which
conducive
conversion
application.
Here,
an
overview
categories
nanoplatform‐based
vectors,
limitations
on
development,
applications
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
Molecular
imaging
has
significantly
advanced
the
detection
and
analysis
of
in
vivo
metabolic
processes,
while
single‐modal
techniques
remain
limited.
Dual‐modal
imaging,
particularly
positron
emission
tomography
(PET)‐based
combinations
emerged
as
a
powerful
solution,
offering
enhanced
capabilities
through
integration
with
magnetic
resonance
(MRI)
or
near‐infrared
fluorescence
(NIRF)
imaging.
This
review
highlights
recent
progress
PET‐based
dual‐modal
focusing
on
development
various
bimodal
probes
derived
from
antibodies,
nanoparticles,
peptides,
key
applications
including
image‐guided
surgery
disease
assessment.
holds
substantial
potential
for
advancing
research
diagnostics
by
improving
resolution
providing
functional
insights.
By
combining
complementary
modalities,
these
systems
deliver
more
comprehensive
view
leading
to
accurate
diagnoses
targeted
treatments.
Future
prioritizes
optimizing
probe
design
biocompatibility
safety,
facilitating
clinical
translation,
broadens
beyond
cancer.
Through
interdisciplinary
collaboration,
are
poised
play
pivotal
role
patient
outcomes,
diagnosing
managing
complex
diseases.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 21, 2024
Immuno-stimulative
effect
of
chemotherapy
(ISECT)
is
recognized
as
a
potential
alternative
to
conventional
immunotherapies,
however,
the
clinical
application
constrained
by
its
inefficiency.
Metronomic
chemotherapy,
though
designed
overcome
these
limitations,
offers
inconsistent
results,
with
effectiveness
varying
based
on
cancer
types,
stages,
and
patient-specific
factors.
In
parallel,
wealth
preclinical
nanomaterials
holds
considerable
promise
for
ISECT
improvement
modulating
cancer-immunity
cycle.
area
biomedical
nanomaterials,
current
literature
reviews
mainly
concentrate
specific
category
nanotechnological
perspectives,
while
two
essential
issues
are
still
lacking,
i.e.,
comprehensive
analysis
addressing
causes
inefficiency
thorough
summary
elaborating
improvement.
This
review
thus
aims
fill
gaps
catalyze
further
development
in
this
field.
For
first
time,
comprehensively
discusses
It
then
meticulously
categorizes
six
types
improving
ISECT.
Subsequently,
practical
strategies
proposed
inefficient
ISECT,
along
detailed
discussion
exemplary
nanomedicines.
Finally,
provides
insights
into
challenges
perspectives
chemo-immunotherapy
innovations
nanomaterials.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 12, 2024
Abstract
The
injectable
hydrogels
can
deliver
the
loads
directly
to
predetermined
sites
and
form
reservoirs
increase
enrichment
retention
of
in
target
areas.
preparation
injection
involve
sol–gel
transformation
hydrogels,
which
is
affected
by
factors
such
as
temperature,
ions,
enzymes,
light,
mechanics
(self‐healing
property),
pH.
However,
tracing
injection,
degradation,
drug
release
from
based
on
different
ways
gelation
a
major
concern.
To
solve
this
problem,
contrast
agents
are
introduced
into
enabling
be
imaged
under
techniques
fluorescence
imaging,
photoacoustic
magnetic
resonance
radionuclide
imaging.
This
review
details
methods
for
causing
imageable
hydrogels;
discusses
application
containing
various
imaging
techniques,
finally
explores
potential
challenges
modes
gelation.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 351 - 351
Published: March 18, 2025
Curcumin,
a
polyphenol
found
in
turmeric,
demonstrates
multifaceted
anti-cancer
activity
against
glioblastoma.
Its
therapeutic
potential
stems
from
its
ability
to
modulate
various
molecular
pathways
implicated
glioblastoma
development
and
progression,
enhance
the
effectiveness
of
radiation
therapy,
induce
cancer
cell
death
through
diverse
mechanisms,
including
apoptosis,
autophagy,
cycle
arrest.
These
combined
actions
make
curcumin
promising
candidate
for
treatment,
warranting
further
investigation
into
clinical
application.
In
this
review,
we
summarize
latest
research
on
analogs'
therapy.
View,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Abstract
The
precision
of
cancer
immunotherapy
is
critically
dependent
on
accurately
characterizing
the
tumor
immune
microenvironment
(TIME),
which
represents
a
complex
interplay
cellular
components,
cytokines,
and
metabolic
factors.
Traditional
diagnostic
methods
lack
resolution
to
capture
dynamic
molecular
interactions
within
TIME
at
microscale
level.
This
review
focuses
recent
advancements
in
measurements
for
identifying
novel
immune‐oncology
biomarkers
therapeutic
targets
TIME,
emphasizing
importance
high‐fidelity
data
infiltrates
significance
longitudinal
high‐dimensional
analysis
predicting
treatment
responses.
Furthermore,
discusses
impact
reprogramming
potential
new
responses
immunotherapy.
role
nanotechnology
enhancing
detection
checkpoints
development
AI‐based
sensors
real‐time
predictive
modeling
also
explored,
highlighting
these
advanced
technologies
revolutionize
field
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 26, 2024
Background
TGFB-induced
factor
homeobox
2
(TGIF2),
a
member
of
the
Three-Amino-acid-Loop-Extension
(TALE)
superfamily,
has
been
implicated
in
various
malignant
tumors.
However,
its
prognostic
significance
glioma,
impact
on
tumor
immune
infiltration,
and
underlying
mechanisms
glioma
development
remain
elusive.
Methods
The
expression
TGIF2
human
normal
tissues,
brain
gliomas
was
investigated
using
HPA,
TCGA,
GTEx,
GEO
databases.
study
employed
several
approaches,
including
Kaplan-Meier
analysis,
ROC
logistic
regression,
Cox
GO
KEGG
GSEA,
to
explore
relationship
between
clinicopathologic
features,
value,
potential
biological
functions
patients.
infiltration
assessed
through
Estimate,
ssGSEA,
Spearman
analysis.
Genes
coexpressed
with
were
identified,
protein-protein
interaction
(PPI)
network
these
genes
constructed
STRING
database
Cytoscape
software.
Hub
identified
CytoHubba
plugin,
their
clinical
predictive
value
explored.
Furthermore,
vitro
experiments
performed
by
knocking
down
out
siRNA
CRISPR/Cas9
gene
editing,
role
cell
invasion
migration
analyzed
transwell
assay,
scratch
wound-healing
RT-qPCR,
Western
blot.
Results
mRNA
found
be
upregulated
21
cancers,
glioma.
High
associated
phenotypes
poor
prognosis
patients,
indicating
as
an
independent
factor.
elevated
positively
correlated
cycle
regulation,
DNA
synthesis
repair,
extracellular
matrix
(ECM)
components,
response,
signaling
pathways
that
promote
progression.
showed
correlations
Th2
cells,
macrophages,
immunoregulatory
genes.
hub
demonstrated
significant
value.
Additionally,
revealed
knockdown
knockout
inhibited
invasion,
suppressed
epithelial-mesenchymal
transition
(EMT)
phenotype.
Conclusion
emerges
biomarker
for
possibly
linked
EMT.
