Combating Cellular Aging: Frontiers in Biomaterials and Therapies DOI
Senrui Liu, J. Q. Mou, Chen Zhao

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 7(1), P. 1 - 23

Published: Nov. 21, 2024

With the continuous increase in average life expectancy, population aging has become a significant health issue 21st century. The rising prevalence of age-related diseases brought tremendous pressure on social medical systems and economy. Against this backdrop, research anticellular hot spot field biomedicine, biomaterials are showing new trends potential area. Compared to drugs other traditional anti-aging strategies, can be personalized target characteristics different tissues, serving as drug delivery carriers enhance targeting, directly influence cellular process by modulating microenvironment. Furthermore, offer innovative approaches diagnosing building sophisticated models, which our understanding biology behind speed up advancement novel treatments. This review synthesizes latest advancements biomaterial for combating aging, exploring future prospects challenges.

Language: Английский

Thermal-responsive microgels incorporated PVA composite hydrogels: Integration of two-stage drug release and enhanced self-healing ability for chronic wound treatment DOI
Zeying Liu, Huixia Li, Yuyu Huang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159813 - 159813

Published: Jan. 1, 2025

Language: Английский

Citations

1
Metabolic Fingerprint of Dual Body Fluids Deciphers Diabetic Retinopathy DOI Open Access
Yihan Wang,

S H Li,

Tong Li

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Diabetic retinopathy (DR) is a microvascular complication of diabetes, affecting 34.6% diabetes patients worldwide. Early detection and timely treatment can effectively improve the prognosis DR. Metabolomic analysis provides powerful tool for studying pathophysiological processes. Conducting metabolomic analyses on DR‐related biofluids helps identify differential metabolic expressions during disease progression, thereby discovering potential biomarkers to support clinical diagnosis treatment. Here, an innovative workflow vitreous liquid established, machine learning‐based DR platform integrating fingerprint (VL‐MF) plasma (P‐MF) derived via nanoparticle enhanced laser desorption/ionization mass spectrometry developed. Direct VL‐MF P‐MF are obtained with desirable reproducibility (coefficient variation, CV <5%) remarkable speed (3 s per sample), distinguished from healthy controls applying dual biofluid‐MF area under curve (AUC) 0.957. Moreover, biomarker candidate panel AUC 0.945 constructed related pathways identified by metabolomics pathway (MetPA). This work offers multi‐biofluid that not only contribute but also provide solid references other applications.

Language: Английский

Citations

1
Engineered hydrogel platform for diabetic wound healing DOI
Jie Cui, Jianbin Shi, Yanjun Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160379 - 160379

Published: Feb. 1, 2025

Language: Английский

Citations

1
Advances in the research of immunomodulatory mechanism of mesenchymal stromal/stem cells on periodontal tissue regeneration DOI Creative Commons

Dezhi Zhao,

Ruilin Yang,

Han-xiao Wei

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Periodontal disease is a highly prevalent worldwide that seriously affects people's oral health, including gingivitis and periodontitis. Although the current treatment of periodontal can achieve good control inflammation, it difficult to regenerate supporting tissues satisfactory therapeutic effect. In recent years, due tissue regeneration ability, research on Mesenchymal stromal/stem cells (MSCs) MSC-derived exosomes has been gradually deepened, especially its ability interact with microenvironment body in complex immunoregulatory network, which led many new perspectives strategies for diseases. This paper systematically reviews immunomodulatory (including bone immunomodulation) properties MSCs their role inflammatory microenvironment, summarizes pathways mechanisms by MSC-EVs have promoted lists potential areas future research, describes issues should be considered basic direction development "cell-free therapies" regeneration.

Language: Английский

Citations

0
X-ray Responsive Antioxidant Drug-Free Hydrogel for Treatment of Radiation Skin Injury DOI
Yi Xia,

Han Gui,

Xinyi Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 18, 2025

Radiotherapy (RT) is widely applied in tumor therapy, but inevitable side effects, especially for skin radiation injury, are still a fatal problem and life-threatening challenge patients. The main components of topical protection preparations currently available on the market antioxidants, such as SOD, which limited by their unstable activity short duration action, making it difficult to achieve effects damage treatment. Therefore, we designed drug-free antioxidant hydrogel patch with encapsulated bioactive epidermal growth factor (EGF) treatment injury. X-ray responsive formed copolymerization disulfide-containing hyperbranched poly(β-hydrazide ester) macromer polymer (PBAE), methacryloylated hyaluronic acid, acrylamide exhibits continuous through oxidation disulfide bonds PBAE well triggered release EGF after breakage network finally promote radioactive wound healing. Upon radiotherapy, able alleviate local oxidative stress continuously eliminating excessive ROS can prevent deterioration Moreover, its excellent property overcome disadvantages traditional medicine (such poor solubility, random diffusion, rapid drug clearance, interference efficacy). Notably, negligible effect therapy because acts only epidermis displays no shielding ionization radiation. Ultimately, vivo animal studies affirm efficacy our methodology, wherein administration acute irradiated attenuates progression injury promotes This innovative strategy points out new inspiration precise hydrogels.

Language: Английский

Citations

0
Application and progress of smart hydrogel microspheres for regulating oxidative stress in osteoarthritis DOI
Jinping Chen, Chengcheng Du, Bin Tang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160620 - 160620

Published: Feb. 1, 2025

Language: Английский

Citations

0
A Smart MMP‐9‐responsive Hydrogel Releasing M2 Macrophage‐derived Exosomes for Diabetic Wound Healing DOI Open Access
Hao Meng,

Jianlong Su,

Qi Shen

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Chronic diabetic wounds are characterized by prolonged inflammation and excessive accumulation of M1 macrophages, which impede the healing process. Therefore, resolving promptly transitioning to proliferative phase critical steps for effective wound healing. Exosomes have emerged as a promising therapeutic strategy. In this study, smart hydrogel capable responding pathological cues in inflammatory microenvironment promote transition from proliferation delivering M2 macrophage-derived exosomes (M2-Exos) is developed. The synthesized through cross-linking oxidized dextran, matrix metalloproteinase (MMP)-9-sensitive peptide, carboxymethyl chitosan containing M2-Exos. response elevated MMP-9 concentrations microenvironment, demonstrates diagnostic logic, adjusting release kinetics M2-Exos accordingly. on-demand facilitated macrophage polarization phenotype, thereby promoting accelerating transcriptomic analysis further reveals that MMP-9-responsive with delivery exerts anti-inflammatory regenerative effects downregulating inflammation-related pathways. This study introduces an innovative, microenvironment-responsive exosome system enables precise control agent release, offering personalized approach treatment chronic wounds.

Language: Английский

Citations

0
Nanowire-based squalene oleogel repairs skin photoaging DOI Creative Commons
Yan Li, Zeyang Liu, Yibin Zeng

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 25, 2025

Long-term exposure to ultraviolet B (UVB) radiation induces the accumulation of free radicals in skin, resulting oxidative damage and accelerated aging. As a natural anti-oxidant, squalene has been applied as cosmetic additive. Nonetheless, liquid oil state its low solubility water usually limits practical application squalene. Recently, phosphotungstate calcium nanowires synthesized gelatinize oily solvents, making it feasible fabricate stable oleogel formulation containing Herein, squalene/phosphotungstate (Sql/PWC) specifically designed treat skin photoaging. Such was comprised oil-based structures that closely mimic skin's lipids, enhanced penetration, better retention active ingredients within superior stability compared traditional hydrogel, especially under UVB exposure. It found Sql/PWC on UVB-irradiated successfully decreased epidermal thickness, increased dermal promoted expression elastin, collagen barrier marker. Meanwhile, RNA-Sequencing results further revealed alleviated photo-damage through antioxidant anti-inflammatory activities which were key factors aging process. We believe this study will not only bring new perspectives for photoaging treatment but also promotes broader cosmetics industry.

Language: Английский

Citations

0
Polyvinyl pyrrolidone/carboxymethyl chitosan hydrogel loaded with Paris polyphylla var. yunnanensis extracellular vesicles promotes wound healing DOI
Jin-Ling Tang, Cheng Xin, Rui Pan

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141782 - 141782

Published: March 5, 2025

Language: Английский

Citations

0
Combating Cellular Aging: Frontiers in Biomaterials and Therapies DOI
Senrui Liu, J. Q. Mou, Chen Zhao

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 7(1), P. 1 - 23

Published: Nov. 21, 2024

With the continuous increase in average life expectancy, population aging has become a significant health issue 21st century. The rising prevalence of age-related diseases brought tremendous pressure on social medical systems and economy. Against this backdrop, research anticellular hot spot field biomedicine, biomaterials are showing new trends potential area. Compared to drugs other traditional anti-aging strategies, can be personalized target characteristics different tissues, serving as drug delivery carriers enhance targeting, directly influence cellular process by modulating microenvironment. Furthermore, offer innovative approaches diagnosing building sophisticated models, which our understanding biology behind speed up advancement novel treatments. This review synthesizes latest advancements biomaterial for combating aging, exploring future prospects challenges.

Language: Английский

Citations

0