Frontiers in Chemistry,
Journal Year:
2023,
Volume and Issue:
11
Published: Nov. 24, 2023
Hafnium-based
nanomaterials
(Hf-NMs)
have
attracted
the
interest
of
numerous
biomedical
researchers
by
their
unique
properties.
Recent
years
witnessed
significant
advancements
in
field
nanomaterials,
particularly
context
cancer
diagnosis
and
treatment.
However,
research
this
area,
especially
concerning
clinical
application
has
not
been
thoroughly
reviewed.
This
review
will
cover:
1)
Classification
synthesis
including
Hafnium
oxide
Metal-Organic
Frameworks/nanoscale
coordination
polymers
(MOFs/NCPs);
2)
act
as
contrast
enhancement
agent
for
imaging,
hafnium-based
used
liquid
biopsy;
3)
therapy,
radiotherapy,
photodynamic
various
combined
therapy;
4)
Translation,
toxicity,
safety
Hf-NMs
human
preclinical
animal
models.
More
attention
be
given
to
translation
cancer.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(21), P. 20825 - 20849
Published: Nov. 3, 2023
Understanding
the
in
vivo
transport
of
nanoparticles
provides
guidelines
for
designing
nanomedicines
with
higher
efficacy
and
fewer
side
effects.
Among
many
factors,
size
plays
a
key
role
controlling
their
behaviors
due
to
existence
various
physiological
thresholds
within
body
size-dependent
nano-bio
interactions.
Encouraged
by
evolving
discoveries
nanoparticle-size-dependent
biological
effects,
we
believe
that
it
is
necessary
systematically
summarize
size-scaling
laws
nanoparticle
vivo.
In
this
review,
summarized
effect
on
along
journey
body:
begin
administration
via
different
delivery
routes,
followed
targeting
intended
tissues
including
tumors
other
organs,
eventually
clearance
through
liver
or
kidneys.
We
outlined
tools
investigating
as
well.
Finally,
discussed
how
may
leverage
tackle
some
challenges
nanomedicine
translation
also
raised
important
size-related
questions
remain
be
answered
future.
Industrial & Engineering Chemistry Research,
Journal Year:
2022,
Volume and Issue:
61(22), P. 7547 - 7593
Published: May 16, 2022
Nature
has
inspired
scientists
to
develop
green
and
sustainable
nanomaterials
with
biomimetic
functions.
Particularly,
metallic
nanostructures
(biometal
NPs)
unique
optical,
catalytic,
electrical
properties
have
received
tremendous
attention
in
many
fields,
ranging
from
healthcare
agriculture
energy
environmental
sciences.
Biometal
NPs
synthesized
by
various
natural
resources
such
as
plant
extracts,
biomolecules,
bacteria,
even
viruses
possess
functions
including
but
not
limited
precise
biorecognition,
self-assembly,
antibacterial/antiviral,
enzymatic
properties.
In
this
report,
we
first
review
the
bioinspired
synthesis
of
industrially
important
metal
nanoparticles,
followed
discussion
on
how
different
biological
sources
affect
as-synthesized
biometal
NPs.
Next,
recent
advancement
applications
these
fields
biomedical
engineering
catalysis,
which
include
development
nanobiosensors,
imaging
probes,
nanotherapeutics
(e.g.,
antimicrobial
photodynamic/photothermal
therapeutic
agents),
well
design
multifunctional
nanozymes
artificial
metalloenzymes
for
chemical
biopharmaceutical
industries.
Finally,
highlight
some
latest
advancements
nanobiomimicry
their
emerging
clean
energy,
electronic
devices,
data
storage,
shows
game-changing
role
technological
near
future.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Sept. 27, 2023
Abstract
Lymph
nodes
(LNs)
are
important
hubs
for
metastatic
cell
arrest
and
growth,
immune
modulation,
secondary
dissemination
to
distant
sites
through
a
series
of
mechanisms,
it
has
been
proved
that
lymph
node
metastasis
(LNM)
is
an
essential
prognostic
indicator
in
many
different
types
cancer.
Therefore,
oncologists
understand
the
mechanisms
tumor
cells
metastasize
LNs,
as
well
how
LNM
affects
prognosis
therapy
patients
with
cancer
order
provide
accurate
disease
assessment
effective
treatment
strategies.
In
recent
years,
updates
both
basic
clinical
studies
on
application
advanced
medical
technologies,
much
progress
made
understanding
strategies
diagnosis
LNM.
this
review,
current
knowledge
anatomical
physiological
characteristics
molecular
LNM,
described.
The
significance
summarized,
including
roles
playing
staging,
prediction,
selection
various
cancers.
And
novel
exploration
academic
disputes
recognition,
diagnosis,
therapeutic
interventions
LNs
also
discussed.
Advances in Colloid and Interface Science,
Journal Year:
2024,
Volume and Issue:
332, P. 103263 - 103263
Published: July 31, 2024
The
growing
field
of
nanotechnology
has
witnessed
numerous
advancements
over
the
past
few
years,
particularly
in
development
engineered
nanoparticles.
Compared
with
bulk
materials,
metal
nanoparticles
possess
more
favorable
properties,
such
as
increased
chemical
activity
and
toxicity,
owing
to
their
smaller
size
larger
surface
area.
Metal
exhibit
exceptional
stability,
specificity,
sensitivity,
effectiveness,
making
them
highly
useful
biomedical
field.
are
high
demand
nanotechnology,
including
Au,
Ag,
Pt,
Cu,
Zn,
Co,
Gd,
Eu,
Er.
These
particles
excellent
physicochemical
amenable
functionalization,
non-corrosiveness,
varying
optical
electronic
properties
based
on
shape.
can
be
modified
different
targeting
agents
antibodies,
liposomes,
transferrin,
folic
acid,
carbohydrates.
Thus,
hold
great
promise
for
various
applications
photoacoustic
imaging,
magnetic
resonance
computed
tomography
(CT),
photothermal,
photodynamic
therapy
(PDT).
Despite
potential,
safety
considerations,
regulatory
hurdles
must
addressed
safe
clinical
applications.
This
review
highlights
nanoparticle
engineering
explores
integration
emerging
technologies
bioimaging,
cancer
therapeutics
nanomedicine.
By
offering
valuable
insights,
this
comprehensive
offers
a
deep
understanding
potential
research.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(3), P. 3754 - 3807
Published: March 2, 2021
X-ray-based
analytics
are
routinely
applied
in
many
fields,
including
physics,
chemistry,
materials
science,
and
engineering.
The
full
potential
of
such
techniques
the
life
sciences
medicine,
however,
has
not
yet
been
fully
exploited.
We
highlight
current
upcoming
advances
this
direction.
describe
different
methodologies
(including
those
performed
at
synchrotron
light
sources
X-ray
free-electron
lasers)
their
potentials
for
application
to
investigate
nano–bio
interface.
discussion
is
predominantly
guided
by
asking
how
methods
could
better
help
understand
improve
nanoparticle-based
drug
delivery,
though
concepts
also
apply
interactions
general.
discuss
limitations
they
might
be
overcome,
particularly
future
use
vivo.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Sept. 24, 2022
Abstract
Sentinel
lymph
node
imaging
and
biopsy
is
important
to
clinical
assessment
of
cancer
metastasis,
novel
non-radioactive
lymphographic
tracers
have
been
actively
pursued
over
the
years.
Here,
we
develop
gold
molecular
clusters
(Au
25
)
functionalized
by
phosphorylcholine
(PC)
ligands
for
NIR-II
(1000–3000
nm)
fluorescence
draining
nodes
in
4T1
murine
breast
CT26
colon
tumor
mouse
models.
The
Au-phosphorylcholine
(Au-PC)
probes
exhibit
‘super-stealth’
behavior
with
little
interactions
serum
proteins,
cells
tissues
vivo,
which
differs
from
indocyanine
green
(ICG)
dye.
Subcutaneous
injection
Au-PC
allows
mapping
at
an
optimal
time
~
0.5
−
1
hour
postinjection
followed
rapid
renal
clearance.
Preclinical
LN
affords
high
signal
background
ratios
safety
biocompatibility,
promising
future
translation.
Journal of Clinical Medicine,
Journal Year:
2021,
Volume and Issue:
10(24), P. 5757 - 5757
Published: Dec. 9, 2021
The
X-ray
imaging
field
is
currently
undergoing
a
period
of
rapid
technological
innovation
in
diagnostic
equipment.
An
important
recent
development
the
advent
new
detectors,
i.e.,
photon-counting
detectors
(PCD),
which
have
been
introduced
clinical
prototype
systems,
called
PCD
computed
tomography
(PCD-CT)
or
CT
(PCCT)
spectral
(SPCCT)
systems.
allows
pixel
up
to
200
microns
pixels
at
iso-center,
much
smaller
than
that
can
be
obtained
with
conventional
energy
integrating
(EID).
PCDs
also
higher
dose
efficiency
EID
mainly
because
electronic
noise
suppression.
In
addition,
energy-resolving
capabilities
these
allow
generating
basis
imaging,
such
as
mono-energetic
images
water/iodine
material
well
K-edge
contrast
agent
based
on
atoms
high
atomic
number.
years,
studies
therefore
conducted
determine
potential
PCD-CT
an
alternative
for
chest
imaging.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: May 2, 2022
Abstract
As
a
typical
class
of
crystalline
porous
materials,
metal–organic
framework
possesses
unique
features
including
versatile
functionality,
structural
and
compositional
tunability.
After
being
reduced
to
two-dimension,
ultrathin
metal-organic
layers
possess
more
external
excellent
properties
favoring
various
technological
applications.
In
this
review
article,
the
nanosheets
benefiting
from
planar
topography
were
highlighted,
involving
light
transmittance,
electrical
conductivity.
Moreover,
design
strategy
fabrication
methodology
summarized
covering
discussions
on
their
applicability
accessibility,
especially
for
porphyritic
nanosheet.
The
current
achievements
in
bioapplications
two-dimensional
frameworks
presented
comprising
biocatalysis,
biosensor,
theranostic,
with
an
emphasis
reactive
oxygen
species-based
nanomedicine
oncology
treatment.
Furthermore,
challenges
confronting
utilization
future
opportunities
emerging
research
frontiers
presented.
Graphical
