How
to
accurately
diagnose
and
treat
bacterial
infections
in
vivo
remains
a
huge
challenge.
Therefore,
we
have
developed
targeted
delivery
nanosystem
by
coextruding
the
pretreated
macrophage
membrane
of
S.
aureus
with
carbon
dots
(M@CD).
The
M@CD
demonstrates
potent
antibacterial
effects
both
vitro
through
generation
reactive
oxygen
species
(ROS).
Furthermore,
exhibits
enhanced
targeting
ability
stable
fluorescence
properties,
addressing
issues
such
as
poor
efficiency
high
immunogenicity
vivo.
This
innovative
approach
enables
infection
site
specific
aggregation
elimination
infections,
thereby
providing
promising
strategy
for
integrated
diagnosis,
treatment,
monitoring
infections.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(10), P. 4127 - 4146
Published: Jan. 1, 2024
Biomarker-driven
molecular
imaging
has
emerged
as
an
integral
part
of
cancer
precision
radiotherapy.
The
use
probes,
including
nanoprobes,
have
been
explored
in
radiotherapy
to
precisely
and
noninvasively
monitor
spatiotemporal
distribution
biomarkers,
potentially
revealing
tumor-killing
mechanisms
therapy-induced
adverse
effects
during
radiation
treatment.
We
report
the
assembly
of
poly(ethylene
glycol)
nanoparticles
(PEG
NPs)
and
optimize
their
surface
chemistry
to
minimize
formation
protein
coronas
immunogenicity
for
improved
biodistribution.
PEG
NPs
cross-linked
with
disulfide
bonds
are
synthesized
utilizing
zeolitic
imidazolate
framework-8
as
templates,
which
subsequently
modified
molecules
different
end
groups
(carboxyl,
methoxy,
or
amino)
vary
chemistry.
Among
modifications,
amino
residual
carboxyl
form
a
pair
zwitterionic
structures
on
NPs,
adsorption
proteins
(e.g.,
immunoglobulin,
complement
proteins)
maximize
blood
circulation
time.
The
influence
preexisting
antibodies
in
mice
pharmacokinetics
is
negligible,
demonstrates
resistance
anti-PEG
inhibition
accelerated
clearance
phenomenon.
This
research
highlights
importance
PEGylated
design
delivery
systems
reveals
translational
potential
cancer
therapy.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
19(5), P. 5253 - 5268
Published: Jan. 31, 2025
Methicillin-resistant
Staphylococcus
aureus
(MRSA)
causes
osteomyelitis
(OM),
which
seriously
threatens
public
health
due
to
its
antimicrobial
resistance.
To
increase
the
sensitivity
of
antibiotics
and
eradicate
intracellular
bacteria,
a
Zn2+
vancomycin
(Van)
codelivered
nanotherapeutic
(named
Man-Zn2+/Van
NPs)
was
fabricated
characterized
via
mannose
(Man)
modification.
NPs
exhibit
significant
inhibitory
activity
against
extra-
MRSA
obviously
decrease
minimum
concentration
Van.
can
be
easily
internalized
by
MRSA-infected
macrophages
significantly
accumulated
in
infected
bone
Man-mediated
targeting.
In
vivo
experiments
mouse
OM
model
verified
that
reduce
burden,
improve
gait
patterns,
mass,
inflammatory
cytokine
expression.
The
antibacterial
mechanism
includes
destruction
membrane,
degeneration
proteins
DNA,
inhibition
glycolysis,
intervention
energy
metabolism
bacteria.
Overall,
this
metal-antibiotic
nanotherapeutics
strategy
provides
new
insight
for
combating
infections
caused
MRSA-induced
OM.
Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
Tumor
immunotherapy,
which
utilizes
the
immune
system
to
fight
cancer,
represents
a
revolutionary
method
for
cancer
treatment.
Poly
(lactic-co-glycolic
acid)
(PLGA)
copolymer
has
emerged
as
promising
material
tumor
immunotherapy
due
its
biocompatibility,
biodegradability,
and
versatility
in
drug
delivery.
By
tuning
size,
shape,
surface
properties
of
PLGA-based
systems,
researchers
have
improved
their
ability
align
with
requirements
diverse
modalities.
In
this
review,
basic
PLGA
materials
are
first
introduced
further
principal
forms
systems
controlled
release
summarized
delivery
applications
targeted.
addition,
recent
advances
use
highlighted
enhance
antitumor
responses
terms
vaccines,
immunogenic
cell
death-mediated
responses,
microenvironment
modulation,
combination
immunotherapies.
Finally,
prospects
future
research
clinical
translation
proposed.
