Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(10)
Published: Nov. 27, 2023
Abstract
Precision
medicine
requires
precise
regulation
of
drugs
in
terms
time,
space,
and
dosage.
Exogenous
control
systems,
such
as
electrical
responsiveness,
have
made
great
progress.
However,
wearable
or
implantable
controlled
drug
release
devices
still
face
major
challenges
due
to
limitations
including
limited
battery
life,
large
size,
fixed
power
supply.
To
overcome
these
limitations,
the
fabrication
autonomous
is
available
endure
extended
periods
without
reliance
on
external
sources.
As
a
promising
strategy,
nanogenerators
(NGs)
turn
body
mechanical
energy
into
electricity,
powering
long‐term
release.
In
this
review,
current
status
delivery
systems
(DDS)
briefly
outlined
importance
self‐driven
emphasized.
The
main
types
operational
mechanisms
various
are
introduced.
This
review
also
focuses
summarizing
latest
progress
self‐powered
based
(NG‐based
CDRs).
Additionally,
their
applications
field
introduced
detail.
Finally,
existing
future
trends
NG‐based
CDRs
discussed
from
perspectives
clinical
needs
practical
translation.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(12), P. 14059 - 14071
Published: March 17, 2022
Diabetic
foot
ulcer
is
a
serious
complication
in
diabetes
patients,
imposing
physical
and
economic
burden
to
patients
the
healthcare
system
as
whole.
Oxidative
stress
thought
be
key
driver
of
pathogenesis
such
ulcers.
However,
no
antioxidant
drugs
have
received
clinical
approval
date,
underscoring
need
for
further
development
medications.
Hydrogels
can
applied
directly
wound
site,
wherein
they
function
prevent
infection
maintain
local
moisture
concentrations,
addition
serving
reservoir
delivery
range
therapeutic
compounds
with
potential
expedite
healing
synergistic
manner.
Herein,
we
synthesized
Prussian
blue
nanoparticles
(PBNPs)
capable
efficiently
scavenging
reactive
oxygen
species
(ROS)
owing
their
ability
mimic
activity
catalase
(CAT),
peroxidase
(POD),
superoxide
dismutase
(SOD).
In
context
vitro
oxidative
stress,
these
PBNPs
were
able
protect
against
cytotoxicity,
mitochondria
from
stress-related
damage,
restore
nuclear
factor
erythroid
2-related
2
(NRF2)/heme
oxygenase-1
(HO-1)
pathway
activity.
To
expand
on
results
an
vivo
context,
prepared
thermosensitive
poly
(d,l-lactide)-poly(ethylene
glycol)-poly(d,l-lactide)
(PDLLA-PEG-PDLLA)
hydrogel
(PLEL)-based
dressing
which
had
been
homogenously
incorporated,
then
used
this
platform
controlled
PBNP
release.
The
resultant
PBNPs@PLEL
was
improve
diabetic
healing,
decrease
ROS
production,
promote
angiogenesis,
reduce
pro-inflammatory
interleukin-6
(IL-6)
tumor
necrosis
factor-α
(TNF-α)
levels
within
wounds.
Overall,
our
suggest
that
holds
great
promise
treatment
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 21, 2024
Abstract
Inflammation-associated
diseases
encompass
a
range
of
infectious
and
non-infectious
inflammatory
diseases,
which
continuously
pose
one
the
most
serious
threats
to
human
health,
attributed
factors
such
as
emergence
new
pathogens,
increasing
drug
resistance,
changes
in
living
environments
lifestyles,
aging
population.
Despite
rapid
advancements
mechanistic
research
development
for
these
current
treatments
often
have
limited
efficacy
notable
side
effects,
necessitating
more
effective
targeted
anti-inflammatory
therapies.
In
recent
years,
nanotechnology
has
provided
crucial
technological
support
prevention,
treatment,
detection
inflammation-associated
diseases.
Various
types
nanoparticles
(NPs)
play
significant
roles,
serving
vaccine
vehicles
enhance
immunogenicity
carriers
improve
targeting
bioavailability.
NPs
can
also
directly
combat
pathogens
inflammation.
addition,
facilitated
biosensors
pathogen
imaging
techniques
This
review
categorizes
characterizes
different
NPs,
summarizes
their
applications
It
discusses
challenges
associated
with
clinical
translation
this
field
explores
latest
developments
prospects.
conclusion,
opens
up
possibilities
comprehensive
management
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 24, 2023
Abstract
The
stimuli-responsive
nanofibers
prepared
by
electrospinning
have
become
an
ideal
material
due
to
their
large
specific
surface
area
and
porosity,
which
can
respond
extremely
quickly
external
environmental
incitement.
As
intelligent
drug
delivery
platform,
efficiently
load
drugs
then
be
stimulated
conditions
(light,
temperature,
magnetic
field,
ultrasound,
pH
or
ROS,
etc.)
achieve
slow,
on-demand
targeted
release,
showing
great
potential
in
areas
such
as
delivery,
tumor
therapy,
wound
dressing,
tissue
engineering.
Therefore,
this
paper
reviews
the
recent
trends
of
electrospun
platforms
field
biomedicine.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
35, P. 181 - 207
Published: Feb. 2, 2024
Peptide
molecules
have
design
flexibility,
self-assembly
ability,
high
biocompatibility,
good
biodegradability,
and
easy
functionalization,
which
promote
their
applications
as
versatile
biomaterials
for
tissue
engineering
biomedicine.
In
addition,
the
functionalization
of
self-assembled
peptide
nanomaterials
with
other
additive
components
enhances
stimuli-responsive
functions,
promoting
function-specific
that
induced
by
both
internal
external
stimulations.
this
review,
we
demonstrate
recent
advance
in
molecular
design,
self-assembly,
functional
tailoring,
biomedical
peptide-based
nanomaterials.
The
strategies
on
synthesis
single,
dual,
multiple
various
dimensions
are
analyzed,
regulation
active
such
metal/metal
oxide,
DNA/RNA,
polysaccharides,
photosensitizers,
2D
materials,
others
discussed.
designed
temperature-,
pH-,
ion-,
light-,
enzyme-,
ROS-responsive
abilities
drug
delivery,
bioimaging,
cancer
therapy,
gene
antibacterial,
well
wound
healing
dressing
presented
This
comprehensive
review
provides
detailed
methodologies
advanced
techniques
from
biology,
materials
science,
nanotechnology,
will
guide
inspire
level
peptides
specific
functions
applications.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(2), P. 351 - 351
Published: Feb. 8, 2023
The
effective
prevention
and
treatment
of
bacterial
infections
is
imperative
to
wound
repair
the
improvement
patient
outcomes.
In
recent
years,
nanomaterials
have
been
extensively
applied
in
infection
control
healing
due
their
special
physiochemical
biological
properties.
Incorporating
antibacterial
into
dressing
has
associated
with
improved
biosafety
enhanced
outcomes
compared
naked
nanomaterials.
this
review,
we
discuss
progress
application
nanomaterial-based
dressings
for
advanced
management
infected
wounds.
Focus
given
therapy
as
well
all-in-one
detection
infections.
Notably,
highlight
use
nanoparticles
intrinsic
performances,
such
metals
metal
oxide
that
are
capable
killing
bacteria
reducing
drug-resistance
through
multiple
antimicrobial
mechanisms.
addition,
proven
be
ideal
drug
carriers
delivery
release
antimicrobials
either
passive
or
stimuli-responsive
manners.
ability
kill
based
on
photo-triggered
heat
(photothermal
therapy)
ROS
(photodynamic
therapy),
unparalleled
advantages
control.
Moreover,
examples
intelligent
can
detect
in-situ
while
providing
timely
Finally,
challenges
current
provide
further
perspectives
future
healing.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: April 23, 2024
Abstract
Currently,
microbial
infections
have
posed
an
arduous
challenge
to
global
public
health,
whereas
the
rise
of
antibiotic
resistance
is
rendering
traditional
therapies
futile,
prompting
development
new
antimicrobial
technologies.
Photoactive
nanomaterials
thus
garnered
a
thriving
interest
for
disinfection
owing
their
superior
antibacterial
efficaciousness,
favorable
biosafety,
and
rapidness
spatiotemporal
precision
in
excreting
bactericidal
actions.
The
review
summarizes
recent
advances
emerging
trends
design,
nanoengineering,
bioapplications
photoactive
antimicrobials.
It
commences
by
elaborating
fundamental
theories
on
bacterial
resistance,
mechanisms
phototherapy.
Subsequently,
regulation
effectiveness
comprehensively
discussed,
centering
criteria
strategies
tuning
photoabsorption
spectra,
photothermal
conversion,
photocatalytic
efficiency,
alongside
tactics
enabling
synergistic
therapies.
This
followed
comparative
analyses
techniques
modalities
synthesizing
engineering
with
diverse
structures,
forms,
functionalities.
Thereafter,
state‐of‐the‐art
applications
phototherapies
across
various
medical
sectors
are
portrayed,
key
challenges
opportunities
finally
discussed
spur
future
innovations
translation.
envisaged
provide
useful
guidance
devising
developing
nanomaterials‐based
photoresponsive
antimicrobials
application‐specific
materials
properties
biological
functions.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(5)
Published: March 15, 2024
Abstract
Recently,
the
field
of
nanomedicine
has
witnessed
substantial
advancements
in
development
nanocarriers
for
targeted
drug
delivery,
emerges
as
promising
platforms
to
enhance
therapeutic
efficacy
and
minimize
adverse
effects
associated
with
conventional
chemotherapy.
Notably,
deformable
have
garnered
considerable
attention
due
their
unique
capabilities
size
changeable,
tumor‐specific
aggregation,
stimuli‐triggered
disintegration,
morphological
transformations.
These
present
significant
opportunities
revolutionizing
delivery
strategies,
by
responding
specific
stimuli
or
environmental
cues,
enabling
achieved
various
functions
at
tumor
site,
including
size‐shrinkage
penetration,
aggregative
retention
effect,
disintegrating
enable
controlled
release,
shape‐changing
improve
cellular
uptake,
allowing
personalized
treatment
approaches
combination
therapies.
This
review
provides
an
overview
recent
developments
applications
enhancing
therapy,
underscores
diverse
design
strategies
employed
create
elucidates
remarkable
potential
therapy.
