Materials & Design,
Journal Year:
2023,
Volume and Issue:
237, P. 112535 - 112535
Published: Dec. 6, 2023
Oral
squamous
cell
carcinoma
(OSCC)
produces
malignant
tumours
in
the
oral
cavity
and
adjacent
anatomical
structures,
ranking
sixth
among
11
most
common
body.
The
poor
surgical
outcomes
for
OSCC
have
led
to
increasing
interest
nanomedicines.
Major
challenges
with
concentration-dependent
therapies
include
effective
precise
delivery
of
gases
lesion
combination
other
achieve
treatment.
Herein,
novel
Cu2Se
nanosheets
(Cu2Se
NSs)
were
ingeniously
synthesized
enveloped
a
thermosensitive
nitric
oxide
(NO)
supplier
(sodium
nitroprusside
dihydrate,
SNP)
within
sodium
alginate
(ALG)
hydrogel
matrix
effectively
eradicate
by
combining
photothermal
therapy
(PTT)
gas
(GT).
NSs
reduced
glutathione
(GSH)
present
high
concentrations
disulfide
(GSSG),
killing
cells
under
1064
nm
laser
irradiation.
Moreover,
NS
wrapped
SNP
exhibited
good
NIR-controlled
NO
release
behaviour,
thus
realizing
combined
application
PTT
GT.
along
is
expected
improve
antitumour
effect
provide
new
solutions
treating
OSCC.
BIO Integration,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: Jan. 1, 2024
Abstract
Cancer
is
a
significant
disease
that
poses
major
threat
to
human
health.
Image-guided
cancer
therapy
refers
series
of
medical
procedures
use
imaging
technology
precisely
locate
and
treat
cancer.
Combining
the
dual
characteristics
images
functional
nanomaterial
(NM)
drug
carriers,
various
integrated
diagnosis
treatment
probes
have
been
developed
for
in
vivo
dynamic
monitoring
therapeutic
effect
evaluation
drugs
based
on
imaging.
Copper
(Cu)-based
NMs
emerged
as
valuable
products
nanotechnology
due
their
unique
physicochemical
properties,
which
are
influenced
by
factors,
such
size,
shape,
surface
properties.
In
field
imaging,
Cu-based
offer
combination
desirable
characteristics,
including
fluorescence
emission,
contrast
enhancement,
radiolabeling
stability.
These
properties
form
foundation
wide
range
modalities.
addition,
can
be
used
carrier
diagnostic
or
synergistic
multiple
modalities
realized
doping
transition
metals
into
heterostructures.
become
an
important
basis
imaging-guided
with
NMs.
this
review
we
introduce
biocompatible
image-guided
provide
overview
promising
outcomes
biomedical
research.
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
Studies
have
reported
on
the
significance
of
copper
incorporated
nanomaterials
(CINMs)
in
cancer
theranostics
and
tissue
regeneration.
Given
their
unique
physicochemical
properties
tunable
nanostructures,
CINMs
are
used
photothermal
therapy
(PTT)
photothermal-derived
combination
therapies.
They
potential
to
overcome
challenges
unsatisfactory
efficacy
conventional
therapies
an
efficient
non-invasive
manner.
This
review
summarizes
recent
advances
CINMs-based
PTT
biomedicine.
First,
classification
structure
introduced.
tumors
guided
by
multiple
imaging
modalities
then
reviewed.
Various
representative
designs
bone,
skin
other
organs
presented.
Furthermore,
biosafety
is
discussed.
Finally,
this
analysis
delves
into
current
that
researchers
face
offers
optimistic
outlook
prospects
clinical
translational
research
field.
aims
at
elucidating
applications
derived
biomedicine
encourage
future
design
translation.
Materials & Design,
Journal Year:
2023,
Volume and Issue:
237, P. 112535 - 112535
Published: Dec. 6, 2023
Oral
squamous
cell
carcinoma
(OSCC)
produces
malignant
tumours
in
the
oral
cavity
and
adjacent
anatomical
structures,
ranking
sixth
among
11
most
common
body.
The
poor
surgical
outcomes
for
OSCC
have
led
to
increasing
interest
nanomedicines.
Major
challenges
with
concentration-dependent
therapies
include
effective
precise
delivery
of
gases
lesion
combination
other
achieve
treatment.
Herein,
novel
Cu2Se
nanosheets
(Cu2Se
NSs)
were
ingeniously
synthesized
enveloped
a
thermosensitive
nitric
oxide
(NO)
supplier
(sodium
nitroprusside
dihydrate,
SNP)
within
sodium
alginate
(ALG)
hydrogel
matrix
effectively
eradicate
by
combining
photothermal
therapy
(PTT)
gas
(GT).
NSs
reduced
glutathione
(GSH)
present
high
concentrations
disulfide
(GSSG),
killing
cells
under
1064
nm
laser
irradiation.
Moreover,
NS
wrapped
SNP
exhibited
good
NIR-controlled
NO
release
behaviour,
thus
realizing
combined
application
PTT
GT.
along
is
expected
improve
antitumour
effect
provide
new
solutions
treating
OSCC.
