Nanoengineered Copper: Revolutionizing Breast Cancer Care

International Journal of Scientific Research in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 12(1), P. 164 - 180

Published: Feb. 3, 2025

Breast cancer continues to rank as a predominant cause of illness and death among women globally, emphasizing the critical need for innovative effective treatment approaches. Traditional methods such chemotherapy, surgery, radiation therapy often face limitations, including toxicity, resistance, non-specific targeting. In recent years, advancements in nanotechnology have brought about transformative solutions, with nanoengineered copper emerging frontrunner. Nanoengineered copper’s unique properties- its catalytic capabilities, biocompatibility, potential surface modification- offer unprecedented opportunities revolutionize breast care. These nanoparticles not only enable precise targeting cells but also improve diagnostic accuracy through advanced imaging techniques. Furthermore, their application photothermal photodynamic therapies provides dual approach destroying while minimizing harm healthy tissues. With ability modulate tumor microenvironment act platform combination therapies, holds immense promise both early detection treatment. This article explores wide-ranging applications copper, from innovations therapeutic breakthroughs, underscoring redefine management patient outcomes.

Language: Английский

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Integrative analysis of single-cell and bulk RNA sequencing reveals the oncogenic role of ANXA5 in gastric cancer and its association with drug resistance

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 7, 2025

Background Gastric cancer (GC) remains a leading cause of cancer-related mortality, with over one million new cases and 769,000 deaths reported in 2020. Despite advancements chemotherapy, surgery, targeted therapies, delayed diagnosis due to overlooked early symptoms leads poor prognosis. Methods We integrated bulk RNA sequencing single-cell datasets from TCGA, GEO, OMIX001073, employing normalization, batch effect correction, dimensionality reduction methods identify key cell populations associated GC invasion epithelial-mesenchymal transition (EMT), as well analyze the tumor immune microenvironment. Results Our analysis identified MUC5AC+ malignant epithelial cluster significant player EMT. Cluster 1, representing this population, exhibited higher EMT scores compared other clusters. Survival showed that high abundance 0 correlated improved survival rates (P=0.012), whereas 1 was poorer outcomes (P=0.045). A prognostic model highlighted ANXA5 GABARAPL2 two critical genes upregulated tumors. High-risk patients demonstrated increased infiltration worse prognosic. Analysis mutation burden (TMB) indicated low TMB high-risk group had worst Wet-lab validation experiments confirmed oncogenic role ANXA5, showing its facilitation proliferation, invasion, migration while suppressing apoptosis. Conclusion This study offers novel insights into subpopulations cells their roles progression. It provides potential therapeutic targets combat GC, contributing crucial understanding fundamental mechanisms drug resistance gastrointestinal cancers.

Language: Английский

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Dual-pathway tumor radiosensitization strategy based on engineered bacteria capable of targeted delivery of AuNPs and specific hypoxia alleviation

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 29, 2025

Radiotherapy efficacy remains constrained by two key challenges: dose-dependent toxicity to healthy tissues at high radiation doses and hypoxia-mediated tumor radioresistance. While radiosensitizers like gold nanoparticles can enhance tumor-specific deposition, their targeted delivery tumors presents a significant hurdle. Bacteria have emerged as promising bio-carriers that not only actively target penetrate complex microenvironments, but also be genetically engineered multifunctional platforms for radiosensitizer hypoxia alleviation. An integrated nanosystem (PCM@AuNPs), composed of bacteria (PCM) (AuNPs), is used increase the effectiveness radiotherapy. PCM colonize sites more effectively, thus improving efficiency radiosensitizers. Furthermore, overexpresses catalase (CAT), which decomposes excess H2O2 into O2, helping mitigate in TME. Under X-ray irradiation, PCM@AuNPs significantly radiosensitization, leading improved growth inhibition while maintaining good biocompatibility. effective strategy based on an (PCM@AuNPs) radiosensitization through multiple pathways developed. This novel bacterial holds great promise enhancing cancer therapy.

Language: Английский

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Epigenetic modifications in breast cancer: from immune escape mechanisms to therapeutic target discovery

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Breast cancer (BC) is one of the most prevalent malignant tumors among women globally, with number cases accounting for even more than 1/3 all tumor patients in women. Recent studies have found that incidence BC increasing every year. Despite great progress made treatment, characteristics cells, such as strong immune evasion, easy recurrence and drug resistance, are still main reasons limiting survival patients. Epigenetics becoming an important method to reveal development cancer, mainly through study DNA methylation, histone modification, chromatin structure changes non-coding RNA. In addition, researchers epigenetic markers potential early detection personalized treatment BC. Inhibitors targeting epigenetically modified enzymes effective treating a wide range provide significant patient quality life. Therefore, this review will comprehensively summarize role modifications development. Second, paper focus on summarizing how induce formation microenvironment (TIME) Targeting mechanism action provides new perspectives unravel complex process development, while paving way novel diagnostic therapeutic targets. future, by integrating multi-omics data enable deeper understanding pathogenesis BC, we be able promote overall precision medicine.

Language: Английский

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Critical role of neem and jujube extracts in stabilizing copper nanostructures: A comparative study in green synthesis of CuNSs

Current Research in Green and Sustainable Chemistry, Journal Year: 2024, Volume and Issue: 9, P. 100437 - 100437

Published: Jan. 1, 2024

Language: Английский

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