Published: Jan. 1, 2024
Language: Английский
Experimental Gerontology, Journal Year: 2024, Volume and Issue: 188, P. 112389 - 112389
Published: March 8, 2024
Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently needed. Kaempferol, flavonoid found in several plants, has emerged as promising candidate for ameliorating ARDs. This comprehensive review examines Kaempferol's chemical properties, safety profile, pharmacokinetics, highlights its potential therapeutic utility against underpinned by distinctive structure, which confers antioxidative anti-inflammatory properties. Kaempferol counteracts reactive oxygen species (ROS) modulates crucial cellular pathways, thereby combating oxidative stress inflammation, hallmarks low toxicity wide margins, demonstrated preclinical clinical studies, further substantiate potential. Compelling evidence supports substantial addressing ARDs through mechanisms, notably anti-inflammatory, antioxidant, anti-apoptotic actions. exhibits versatile neuroprotective effect modulating various proinflammatory signaling including NF-kB, p38MAPK, AKT, β-catenin cascade. Additionally, it hinders formation aggregation beta-amyloid protein regulates brain-derived neurotrophic factors. In terms anticancer potential, kaempferol acts diverse inducing apoptosis, arresting cell cycle at G2/M phase, suppressing epithelial-mesenchymal transition (EMT)-related markers, affecting phosphoinositide 3-kinase/protein kinase B pathways. Subsequent studies should focus on refining dosage regimens, exploring innovative delivery systems, conducting trials to translate these findings into applications.
Language: Английский
Citations
50
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4969 - 4983
Published: Sept. 1, 2023
Abstract: Osteoarthritis (OA) is a prevalent global health concern, posing significant and increasing public challenge worldwide. Recently, nanotechnology-boosted biomaterials have emerged as highly promising strategy for OA therapy due to their exceptional physicochemical properties capacity regulate pathological processes. However, there an urgent need deeper understanding of the potential therapeutic applications these in clinical management diseases, particularly treatment OA. In this comprehensive review, we present extensive discussion current status future prospects concerning therapy. Initially, discuss pathophysiology constraints associated with existing modalities. Subsequently, various types nanomaterials utilized therapy, including nanoparticles, nanofibers, nanocomposites, are thoroughly discussed summarized, elucidating respective advantages challenges. Furthermore, analyze recent preclinical studies that highlight Additionally, research directions evolving field highlighted. By establishing link between structural functions treatment, aim foster advances designing sophisticated OA, ultimately resulting improved efficacy through translation into setting near future. Keywords: nanotechnology, nanomaterials, osteoarthritis, cartilage, RANKL
Language: Английский
Citations
23
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 11, 2025
Abstract Background Alterations in intercellular communication driven by cellular senescence constitute an important factor skin aging. Migrasome, a newly discovered vesicular organelle, efficiently participates communication; however, the relationship between and migrasomes remains unreported. Objective This study aims to explore possible formation, investigate effects of young fibroblast-derived on senescent keratinocytes wound healing aged skin. Result Single-cell RNA sequencing (scRNA-seq) data analysis revealed that fibroblasts exhibited highest level transcriptional variability during aging, degree fibroblast negatively correlated with expression migrasome-associated markers. Further multiplex Immunohistochemistry (mIHC) results suggested younger mouse contained more than older Transmission electron microscopy (TEM) observations demonstrated abundant from individuals. In vitro experiments indicated produced significantly fibroblasts, as confirmed wheat germ agglutinin (WGA) staining scanning (SEM). Importantly, purified were found reduce senescence-associated markers HaCaT cells. vivo, using model naturally mice, we observed derived not only accelerated but also reduced marker Conclusion Migrasomes formation ability aging progress, rejuvenated promoted These findings offer new ideas for alleviating enhancing Graphical abstract
Language: Английский
Citations
1
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 129, P. 111588 - 111588
Published: Jan. 29, 2024
Language: Английский
Citations
8
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3315 - 3332
Published: April 1, 2024
Background: Acute myocardial infarction (AMI) is a common cardiovascular disease in clinic.Currently, there no specific treatment for AMI.Carbon dots (CDs) have been reported to show excellent biological activities, which hold promise the development of novel nanomedicines diseases.Methods: In this study, we firstly prepared CDs from natural herb Curcumae Radix Carbonisata (CRC-CDs) by green, simple calcination method.The aim study investigate cardioprotective effect and mechanism CRC-CDs on isoproterenol (ISO) -induced (MI) rats. Results:The results showed that pretreatment with significantly reduced serum levels cardiac enzymes (CK-MB, LDH, AST) lipids (TC, TG, LDL) st-segment elevation infarct size ECG AMI rats.Importantly, ejection fraction (EF) shortening (FS) were markedly elevated, as was ATPase activity.In addition, could increase superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), reduce malondialdehyde (MDA) reactive oxygen species (ROS) tissue, thereby exerting enhancing antioxidant capacity tissue.Moreover, TUNEL staining image positive apoptotic cells declined after treatment, indicate inhibit cardiomyocyte apoptosis.Importantly, The protective H 2 O -pretreated H9c2 also verified vitro.Conclusion: Taken together, has potential clinical application an anti-myocardial ischemia drug candidate, not only provides evidence further broadening diseases, but offers hope nanomedicine treat intractable diseases.
Language: Английский
Citations
4
Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 21, 2025
The escalating demand for chronic disease management has presented substantial challenges to traditional methods. However, the emergence of Internet Things (IoT) and artificial intelligence (AI) technologies offers a potential resolution by facilitating more precise through data-driven strategies. This review concentrates on utilization IoT mobile sensing devices in managing major diseases such as cardiovascular diseases, cancer, respiratory diabetes. It scrutinizes their efficacy diagnosis when integrated with machine learning algorithms, ANN, SVM, RF, deep models. Through an exhaustive literature review, this study dissects how these aid risk assessment, personalized treatment planning, management. research addresses gap existing concerning application AI specific diseases. particularly demonstrates methodological novelty introducing advanced models based learning, tight frame-based methodologies real-time monitoring systems. employs rigorous examination method, which includes systematically searching relevant databases, filtering that meets inclusion exclusion criteria, adopting quality assessment tools ensure rigor selected studies. identifies biases weaknesses related data collection, algorithm selection, user interaction. platforms integrating algorithms are not only technically viable but also yield economic social advantages real-world applications. Future studies could investigate use quantum computing processing vast medical datasets novel techniques merge biosensors nanotechnology drug delivery surveillance. Furthermore, paper examines recent progress image reconstruction, emphasizing methodologies. We discuss principles, benefits, constraints methods, assessing across diverse contexts.
Language: Английский
Citations
0
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
The geriatric population, comprising ages 65 and above, encounters distinct health obstacles because of physiological changes heightened vulnerability to diseases. New technologies are being investigated tackle the intricate requirements this population. Recent advancements in probiotics nanotechnology offer promising strategies enhance by improving nutrient absorption, modulating gut microbiota, delivering targeted therapeutic agents. Probiotics play a crucial role maintaining homeostasis, reducing inflammation, supporting metabolic functions. However, challenges such as limited viability efficacy harsh gastrointestinal conditions hinder their potential. Advanced can overcome these constraints enhancing through nano-encapsulation, controlled delivery, improvement bioavailability. This review explores synergistic potential advanced addressing age-related concerns. It highlights key developments probiotic formulations, nano-based delivery systems, combined impact on health, immunity, neuroprotection. convergence represents novel transformative approach promoting healthy aging, paving way for innovative interventions.
Language: Английский
Citations
0
Published: July 5, 2023
Rice bran arabinoxylan compound (RBAC) is derived from rice enzymatically treated with Lentinus Edodes mycelium. This review explores biologically active compounds and mechanisms of action that support RBAC as an immunomodulating nutraceutical in generally healthy and/or aging individuals. Thirty-seven (n=37) primary research articles fulfiled the selection criteria for review. Most based on Biobran MGN-3, which consists complex heteropolysaccharides its structure while also containing galactan glucan. was found to invoke immunological activities through direct absorption via digestive tract interaction immune cells at Peyer’s patches. shown promote innate defence by upregulating macrophage phagocytosis enhancing natural killer cell activity lowering oxidative stress. Through induction dendritic maturation, augments adaptive immunity promoting T B lymphocyte proliferation. acts immunomodulator inhibiting mast degranulation during allergic reactions, attenuating inflammation, downregulating angiogenesis modulating cytokines growth factors. be a safe effective neutraceutical improving health, notably individuals reduced function. Human clinical trials geriatric participants have demonstrated prophylactic benefits against viral infection may improve their quality life. Further should explore RBAC’s bioavailability, pharmacodynamics, pharmacokinetics within. Translational assess nuetraceutical population still required, particularly human studies larger sample sizes cohort long follow-up periods.
Language: Английский
Citations
4
Molecules, Journal Year: 2023, Volume and Issue: 28(17), P. 6313 - 6313
Published: Aug. 29, 2023
Rice bran arabinoxylan compound (RBAC) is derived from defatted rice enzymatically treated with Lentinus edodes mycelium. This review explores biologically active compounds and mechanisms of action that support RBAC as an immunomodulating nutraceutical in generally healthy and/or aging individuals. Thirty-seven (n = 37) primary research articles fulfilled the selection criteria for review. Most based on Biobran MGN-3, which consists complex heteropolysaccharides its structure while also containing galactan glucan. was found to invoke immunological activities through direct absorption via digestive tract interaction immune cells at Peyer’s patches. shown promote innate defence by upregulating macrophage phagocytosis enhancing natural killer cell activity lowering oxidative stress. Through induction dendritic maturation, augments adaptive immunity promoting T B lymphocyte proliferation. acts immunomodulator inhibiting mast degranulation during allergic reactions, attenuating inflammation, downregulating angiogenesis modulating cytokines growth factors. has been be a safe effective improving health, notably individuals reduced function. Human clinical trials geriatric participants have demonstrated prophylactic benefits against viral infection may improve their quality life. Further should explore RBAC’s bioavailability, pharmacodynamics, pharmacokinetics within. Translational assess population still required, particularly human studies larger sample sizes cohort long follow-up periods.
Language: Английский
Citations
4
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(1), P. e0288669 - e0288669
Published: Jan. 12, 2024
This paper examines whether nanotechnology projects funded under the European Union (EU) Framework Programmes (FPs) are a possible trigger for path upgrading (i.e., infusion of new technologies in existing traditional sectors) less-advanced regions. First, adoption cluster analysis and set key indicators technological intensity, scientific excellence, human capital, research development expenditure) allowed us to distinguish between 79 more-advanced 127 EU Subsequently, through social network nonparametric testing we were able demonstrate how regions (average degree centrality: 40.5) play marginal role compared with ones 98.5) created within Horizon 2020—i.e., programming cycle implemented 2014–2020 period. Despite this, observed that few (33 out 127) score higher than median terms participation targeted network, thus benefiting from relevant knowledge flows potentially leading re-industrialization processes. The qualitative comparative determine which combinations innovation, socioeconomic factors could facilitate such beneficial interregional interactions related exchange these types primarily what defined as “relative innovativeness,” excellence comparatively high level gross domestic product per capita). Our empirical results provided some clear policy implications. For instance, necessity I) remove barriers impeding more balanced promote widespread renewal industries II) implement coordinated actions designed encourage involvement great majority regions, remain periodically launched FPs.
Language: Английский
Citations
1