Autophagy‐associated non‐coding RNAs: Unraveling their impact on Parkinson's disease pathogenesis

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Parkinson's disease (PD) is a degenerative neurological condition marked by the gradual loss of dopaminergic neurons in substantia nigra pars compacta. The precise etiology PD remains unclear, but emerging evidence suggests significant role for disrupted autophagy-a crucial cellular process maintaining protein and organelle integrity.

Language: Английский

---

ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102327 - 102327

Published: May 10, 2024

Language: Английский

---

Connecting the Dots: LncRNAs in the KRAS Pathway and Cancer

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155570 - 155570

Published: Aug. 29, 2024

Language: Английский

---

The Role of Sirtuin 1 in Ageing and Neurodegenerative Disease: A Molecular Perspective

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102545 - 102545

Published: Oct. 17, 2024

Language: Английский

---

Uncovering the impact of alcohol on internal organs and reproductive health: Exploring TLR4/NF‐kB and CYP2E1/ROS/Nrf2 pathways

Animal Models and Experimental Medicine, Journal Year: 2024, Volume and Issue: 7(4), P. 444 - 459

Published: June 9, 2024

This review delves into the detrimental impact of alcohol consumption on internal organs and reproductive health, elucidating underlying mechanisms involving Toll-like receptor 4 (TLR4)/Nuclear factor kappa light chain enhancer activated B cells (NF-kB) pathway Cytochrome P450 2E1 (CYP2E1)/reactive oxygen species (ROS)/nuclear erythroid 2-related 2 (Nrf2) pathways. The TLR4/NF-kB pathway, crucial for inflammatory immune responses, triggers production pro-inflammatory agents type-1 interferon, disrupting balance between antioxidant responses when tissues are chronically exposed to alcohol. Alcohol-induced dysbiosis in gut microbes heightens wall permeability pathogen-associated molecular patterns (PAMPs), leading liver cell infection subsequent inflammation. Concurrently, CYP2E1-mediated metabolism generates ROS, causing oxidative stress damaging cells, lipids, proteins, deoxyribonucleic acid (DNA). To counteract this imbalance, Nrf2 regulates gene expression, inhibiting progression promoting responses. Excessive intake results elevated enzymes (ADH, CYP2E1, catalase), NADH, acetaldehyde, acetate, damage vital such as heart, brain, lungs. Moreover, negatively affects health by hypothalamic-pituitary-gonadal axis, infertility both men women. These findings underscore profound concerns associated with alcohol-induced damage, emphasizing need public awareness regarding intricate interplay multi-organ impacts consumption.

Language: Английский

---

Exploring Ubiquitin-Specific Proteases as Therapeutic Targets in Glioblastoma

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155443 - 155443

Published: Aug. 1, 2024

Language: Английский

---

Noncoding RNAs in the COVID-19 Saga: An Untold Story

Viral Immunology, Journal Year: 2024, Volume and Issue: 37(6), P. 269 - 286

Published: July 5, 2024

Language: Английский

---

Proteostasis disruption and senescence in Alzheimer’s disease pathways to neurodegeneration

Brain Research, Journal Year: 2024, Volume and Issue: 1845, P. 149202 - 149202

Published: Aug. 30, 2024

Language: Английский

---

Pharmacological, computational, and mechanistic insights into triptolide’s role in targeting drug-resistant cancers

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Language: Английский

---

Tailored therapies for triple-negative breast cancer: current landscape and future perceptions

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

---