International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 12171 - 12188
Published: Nov. 1, 2024
Osteoporosis
is
a
metabolic
disorder
characterized
by
the
loss
of
bone
mass
and
density.
Nucleic
acid-based
therapies
are
among
most
innovative
approaches
for
osteoporosis
management,
although
their
effective
delivery
to
tissue
remains
challenge.
In
this
work,
SFRP1-silencing
GampeR
loaded-nanoparticles
were
prepared
functionalized
with
specific
moieties
improve
targeting
and,
consequently,
therapeutic
efficacy.
would
promote
osteoblastic
differentiation
enhancing
WNT/β-catenin
pathway
thus
diminishing
progression
osteoporosis.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(2), P. e24207 - e24207
Published: Jan. 1, 2024
High
blood
glucose
levels
are
a
hallmark
of
the
metabolic
syndrome
known
as
diabetes
mellitus.
More
than
600
million
people
will
have
by
2045
global
prevalence
disease
continues
to
rise.
Contemporary
antidiabetic
drugs
reduce
hyperglycemia
and
its
consequences.
However,
these
come
with
undesirable
side
effects,
so
it's
encouraging
that
research
into
plant
extracts
bioactive
substances
characteristics
is
on
Natural
remedies
preferable
conventional
anti-diabetic
since
they
safer
for
body,
more
affordable
fewer
potential
adverse
effects.
Biological
macromolecules
such
liposomes,
niosomes,
polymeric
nanoparticles,
solid
lipid
nanoemulsions
metallic
nanoparticles
explored
in
this
review.
Current
drug
restrictions
been
addressed,
effectiveness
plant-based
therapies
has
enhanced
merits
methods.
Plant
extracts'
loading
capacity
carriers'
stability
primary
obstacles
developing
nanocarriers.
Hydrophilic,
hydrophobic,
amphiphilic
covered,
brief
overview
amphipathic
features
phospholipids,
nanocarriers
provided.
Metallic
nanoparticles'
benefits
attendant
risks
highlighted
emphasize
their
efficiency
treating
hyperglycemia.
Researchers
interested
loaded
therapeutics
may
find
current
helpful
Journal of Oral Biology and Craniofacial Research,
Journal Year:
2025,
Volume and Issue:
15(1), P. 129 - 135
Published: Jan. 1, 2025
Retention
is
an
essential
element
of
orthodontic
treatment.
In
the
past
two
decades,
numerous
biological
treatments
have
been
developed
to
alleviate
relapse.
Pharmacologic
bone
modulation
a
viable
approach
mitigate
The
aim
this
investigation
was
determine
whether
administering
nanoemulsion
carbonated
hydroxyapatite-statin
(CHA-statin)
would
increase
Runx-2
expression
and
decrease
Acp
5
in
rats
experiencing
experimental
Forty-eight
(n
=
48)
were
assigned
four
groups:
control,
CHA,
statin,
CHA-statin,
with
12
each
group.
A
30
g
mesial
traction
applied
for
7
days
via
closed-coil
spring
that
connected
first
maxillary
molar
incisor.
To
maintain
moved
teeth,
statin
hydrogel,
CHA-statin
administered
intrasulcularly
every
3
period
days.
removal
devices
facilitated
occurrence
evaluated
using
immunohistochemistry
method.
collected
data
analysis
variance
post
hoc
tests,
p
<
0.05.
significant
reduction
5-positive
cells
group
observed
on
14
relapse
movement
compared
other
groups
(p
0.05),
whereas
average
expressions
significantly
higher
than
1,
7,
during
phase
0.05).
increased
decreased
expression,
thereby
potentially
preventing
rats.
Current Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
31(28), P. 4479 - 4494
Published: Aug. 1, 2024
Nanomedicine's
application
of
nanotechnology
in
medicine
holds
tremendous
potential
for
diagnosing
and
treating
life-threatening
diseases
such
as
cancer.
Unlike
conventional
therapies,
nanomedicine
offers
a
promising
strategy
to
enhance
clinical
outcomes
while
minimizing
severe
side
effects.
The
principle
drug
targeting
enables
specific
delivery
therapeutic
agents
their
intended
sites,
making
it
more
precise
effective
therapy.
Combination
strategies,
the
co-delivery
chemotherapeutic
drugs
with
nucleic
acids
or
receptor-specific
molecules,
are
being
employed
outcomes.
Nanocarriers
systems
designed
using
these
approaches
offer
resourceful
anticancer
Targeted
via
nanotechnology-based
techniques
has
become
an
urgent
need
shown
significant
improvements
implications,
pharmacokinetics,
specificity,
reduced
toxicity,
biocompatibility.
This
review
discusses
extrapolation
nanomaterials
developing
innovative
novel
Additionally,
we
explore
role
concepts
research.
Jordan Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
17(2), P. 344 - 361
Published: June 25, 2024
Aptamers,
which
are
single-stranded
DNA
or
RNA
molecules,
increasingly
recognized
as
important
tools
in
diagnostics
and
therapeutics
across
various
medical
disciplines
such
oncology,
respiratory
diseases,
neurological
disorders.
This
review
provides
a
comprehensive
evaluation
of
the
recent
progress
obstacles
encountered
field
aptamer-based
applications.
Aptamers
have
shown
promise
oncology
for
early
cancer
detection
targeted
drug
delivery,
effectively
reducing
off-target
effects.
They
also
hold
potential
significantly
impacting
management
conditions
asthma
Chronic
Obstructive
Pulmonary
Disease
(COPD)
by
selectively
targeting
cytokines
regulating
inflammatory
response.
In
realm
disorders,
aptamers
offer
novel
methods
influencing
gut-brain
axis
proposing
approaches
specific
therapy.
Despite
these
notable
benefits,
persistent
challenges
remain
areas
molecular
stability,
delivery
mechanisms,
economic
viability.
offers
overview
while
exploring
avenues
future
research.
