A multiscale inflammatory map: linking individual stress to societal dysfunction

Frontiers in Science, Journal Year: 2024, Volume and Issue: 1

Published: March 12, 2024

As populations worldwide show increasing levels of stress, understanding emerging links among inflammation, cognition, and behavior is vital to human planetary health. We hypothesize that inflammation a multiscale driver connecting stressors affect individuals large-scale societal dysfunction and, ultimately, planetary-scale environmental impacts. propose “central map” hypothesis explain how the brain regulates impairs emotion, action. According our hypothesis, these interdependent inflammatory neural processes, inter-individual transmission environmental, infectious, behavioral stressors—amplified via high-throughput digital global communications—can culminate in multiscale, runaway, feed-forward process could detrimentally decision-making at scale, ultimately impairing ability address same stressors. This perspective provide non-intuitive explanations for behaviors relationships cells, organisms, communities potentially including population-level responses as diverse climate change, conflicts, COVID-19 pandemic. To illustrate elucidate its mechanistic underpinnings, we present mathematical model applicable individual test control, healing, implications transmission, intervention (e.g., lifestyle modification or medication), resilience. Future research needed validate model’s assumptions conclusions against empirical benchmarks expand factors/variables employed. Our illustrates need multilayered, stress mitigation interventions, measures, precision therapeutics, ecosystem design. analysis shows coordinated, interdisciplinary, international effort understand nature stress. Doing so would inform creation interventions improve individuals’ lives; enhance communities’ resilience stress; mitigate adverse effects on world.

Language: Английский

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Intergenerational Effects of Maternal Holocaust Exposure on FKBP5 Methylation

American Journal of Psychiatry, Journal Year: 2020, Volume and Issue: 177(8), P. 744 - 753

Published: April 21, 2020

Objective: There is growing evidence that exposure to trauma prior conception can affect offspring. The authors have reported adult offspring of Holocaust survivors showed lower methylation FK506 binding protein 5 (FKBP5) intron 7, site 6 compared with Jewish comparison volunteers. present study sought replicate this finding in a larger sample and examine parental correlates observed effects. Methods: Cytosine was measured blood using pyrosequencing. independent replication consisted 125 31 control subjects. Additional analyses, performed 147 40 subjects included the previously studied participants, examined associations trauma–related variables (i.e., sex exposed parent, posttraumatic stress disorder, age at exposure) characteristics childhood exposure, lifetime psychiatric diagnoses, psychotropic medication use, FKBP5 rs1360780 genotype, gene expression, neuroendocrine measures) methylation. Results: significantly than subjects, an effect associated maternal self-reported anxiety symptoms. expression elevated indices glucocorticoid sensitivity but not basal expression. Conclusions: This replicates extends decrement predominance mothers during implicates developmental programming as putative mechanism.

Language: Английский

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Structural Racism in the COVID-19 Pandemic: Moving Forward

The American Journal of Bioethics, Journal Year: 2020, Volume and Issue: 21(3), P. 56 - 74

Published: Dec. 19, 2020

The COVID-19 pandemic has taken a substantial human, social and economic toll globally, but its impact on Black/African Americans, Latinx, American Indian/Alaska Native communities in the U.S. is unconscionable. As continues to combat current cycle prepares for future pandemics, it will be critical learn from rectify past contemporary wrongs. Drawing experiences genomic research intersecting areas medical ethics, health disparities, human rights, this article considers three key COVID-19-related issues: identify remedies; testing, contact tracing surveillance; lingering needs disability. It provides pathway future: community engagement develop culturally-sensitive responses myriad genomic/bioethical dilemmas that arise, establishment of Truth Reconciliation Commission transition country state segregation healthcare outcomes into an equitable prosperous society all.

Language: Английский

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Molecular Decolonization: An Indigenous Microcosm Perspective of Planetary Health

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(12), P. 4586 - 4586

Published: June 25, 2020

Indigenous peoples are resilient with deep traditional knowledge and scientific thought spanning millennia. Global discourse on climate change however has identified populations as being a highly vulnerable group due to the habitation in regions undergoing rapid change, disproportionate burden of morbidity mortality already faced by this population. Therefore, need for self-determination formal recognition knowledges, including micro-level molecular microbial critical foundation planetary health is urgent need. Through process decolonization, even at smallest scale, we define method back our original selves therefore origin story. Our well-being directly reflected suggest, can be rooted through concept which English language emerged from ‘First 1000 Days Australia’ otherwise collectively synthesized globally. It evolving understanding decolonization level, many cultural healing practices subtly embody, that better able translate intricacies within current worldview Western forms discourse.

Language: Английский

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The Roadmap for Resilience: The California Surgeon General's Report on Adverse Childhood Experiences, Toxic Stress, and Health

Published: Dec. 9, 2020

In one of my first acts as Governor, I established the role California Surgeon General.Among all myriad challenges facing our administration on day, addressing persistent to health and welfare people state-especially that youngest Californians-was an essential priority.We led with overwhelming scientific consensus upstream factors, including toxic stress social determinants health, are root causes many most harmful challenges, from heart disease homelessness.An issue so critical 40 million Californians deserved nothing less than a world-renowned expert advocate.Appointed in 2019 be firstever General, Dr. Nadine Burke Harris brought groundbreaking research expertise childhood trauma adversity State's efforts.In this new role, set three key priorities -early childhood, equity Adverse Childhood Experiences (ACEs) -and is working across give voice science evidence-based practices foundational success work state.The Office General has already strong programs, first-in-the-nation ACEs Aware initiative, partnership Department Health Care Services (DHCS), taking systematic science-based approach by training healthcare providers screen for children adults.We have also matched resolve funding.Through Initiative Advance Precision Medicine, we invested $9 demonstration projects address impacts using precision medicine approaches.California leading way public crisis because it one.This preventive measure improve societal outcomes state's residents generations come.As collectively face unprecedented confluence challenges-the COVID-19 pandemic, ensuing economic recession, ongoing national reckoning racial injustice, devastating wildfires exacerbated climate change-our state communities grateful Harris' leadership respond waves upon us.It responsibility meet moment.This report provides roadmap systemic equitable forward, based cross-sector partnerships.We must listen advised evidence clearly tells us cumulative adversity, particularly when experienced early life, cause some detrimental, longest lasting costly nation.This highlights how stress, if unaddressed, will cost over trillion dollars next 10 years due costs direct care life lost poor disability or death.It clear me implementing type evidence-based, responses necessary decrease burden not only ethical moral imperative, but vitality.This General's Report offers insights policymakers, scientists, providers, educators, advocates, advances solutions approaches better safety Golden now future.Furthermore, exceptional blueprint can truly stage well-being countless here elsewhere nation world.

Language: Английский

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