Cross-sectional studies: Is pressing the pause button worth it in research?

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 85, P. 32 - 33

Published: June 22, 2024

Language: Английский

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Association Between Fine Particle Waves and Sexual Function: A Nationwide Cross-Sectional Survey in China

Toxics, Journal Year: 2025, Volume and Issue: 13(1), P. 39 - 39

Published: Jan. 6, 2025

The effect of the long-term persistently elevated air pollutants, often referred to as pollution waves, on sexual function has not been sufficiently addressed. This nationwide cross-sectional study involved 12,157 participants, with 5496 females and 5039 males. PM waves were characterized by daily average concentrations surpassing Grade II thresholds China's ambient quality standards (PM2.5 > 75 μg/m3, PM10 150 μg/m3) for three or more consecutive days (3-8 days). Male was assessed through International Index Erectile Function-5 (IIEF-5) Premature Ejaculation Diagnostic Tool (PEDT), while female evaluated using Female Sexual Function (FSFI). A multivariate linear regression model employed investigate link between wave exposure function. Exposure defined 3 (β = -0.0145, 95%CI -0.0280, -0.0010), 4 5 -0.0193, -0.0371, -0.0015), 6 -0.0218, -0.0415, -0.0021), 7 -0.0243, -0.0458, -0.0028), 8 -0.0028) days, negatively impacted IIEF-5 scores male Moreover, depression levels, PHQ-9, played a mediating role in connection scores. potentially vulnerable subgroups younger 20-30 low-income groups. Our results suggest first time that are associated decreased scores, which mediated score informing policy formulation public health interventions individual safeguarding.

Language: Английский

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Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117658 - 117658

Published: Jan. 1, 2025

The causal relationship between PM2.5 (particulate matter with an aerodynamic diameter ≤2.5 μm) and common mental disorders, along its neuropathological mechanisms, remains unclear. We used genome-wide association study datasets from the UK Biobank Psychiatric Genomics Consortium to systematically investigate nine psychiatric disorders using two-sample Mendelian randomization (TSMR) methods. Subsequently, we two-step MR mediating effect of 108 potential mediators in disorders. Our findings indicated that was positively associated major depressive disorder (odds ratio (OR): 1.33, 95 % confidence interval (CI): 1.11-1.55), anxiety (OR: 2.96, CI: 2.13-3.79), schizophrenia 1.55, 1.29-1.81), attention deficit hyperactivity (ADHD) 1.95, 1.66-2.24). Unexpectedly, inversely bipolar 0.65, 0.37-0.93). Additionally, not significantly autism spectrum 1.24, 0.83-1.65), post-traumatic stress 1.51, 1.11-1.91), obsessive-compulsive 0.81, -0.07-1.69), or anorexia nervosa 1.42, 0.86-1.98). Further analysis revealed Neurotrophin-3 mediated 9.86 PM2.5-ADHD 5.88 PM2.5-schizophrenia association. Sensitivity analyses supported these findings. This TSMR provides a comprehensive examination exposure mediation offering insight into underlying mechanisms. aims raise public awareness how air quality affects health through empirical evidence.

Language: Английский

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Short-Term Effect of Air Pollution on Daily Hospital Visits for Anxiety Disorders in Southern China with Low Pollution Concentrations

Toxics, Journal Year: 2025, Volume and Issue: 13(1), P. 45 - 45

Published: Jan. 9, 2025

The global prevalence and burden of anxiety disorders (ADs) are increasing. However, findings on the acute effects air pollution ADs remain inconclusive. We evaluated short-term exposure to ambient pollutants, including fine particulate matter (PM2.5), inhalable (PM10), nitrogen dioxide (NO2), carbon monoxide (CO), sulfur (SO2), ozone (O3), daily hospital visits for ADs. A generalized additive model was used perform a time-series analysis data from Southern China city's medical insurance system between 1 March 2021, 31 July 2023. Although levels most pollutants (PM10, SO2, CO, NO2 O3) were consistently below WHO's Ambient Air-Quality Standards, significant associations observed all six pollutants. Each interquartile range increase in concentrations resulted largest odds ratios 1.08 (95% CI: 1.01, 1.16) at lag1 PM2.5, 1.19 1.05, 1.34) lag07 NO2, 1.14 1.23) lag02 1.12 1.25) PM10, 1.06 1.12) lag7 SO2 1.15) O3, respectively. CO remained robust across subgroup analyses sensitivity analyses. Females middle-aged individuals showed stronger than other subgroups. underscore necessity public health efforts alleviate impact mental health, even low-concentration settings.

Language: Английский

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Modelling the impact of environmental and social determinants on mental health using generative agents

npj Digital Medicine, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 17, 2025

Abstract Mental health is shaped by socio-environmental determinants, yet traditional research approaches struggle to capture their complex interactions. This review explores the potential of generative agents, powered large language models, simulate human-like behaviour in virtual environments for mental research. We outline applications including modelling adverse life events, urbanicity, climate change, discuss challenges and describe how agents could transform

Language: Английский

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How objective and subjective greenspace, combined with air and noise pollution, impacts mental health through the mediation of physical activity

Urban forestry & urban greening, Journal Year: 2025, Volume and Issue: unknown, P. 128683 - 128683

Published: Jan. 1, 2025

Language: Английский

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Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: 51, P. 104472 - 104472

Published: Jan. 5, 2025

Cholangiocarcinoma is a rare and often fatal malignancy. Numerous studies have demonstrated promising outcomes survival rates associated with adjuvant photodynamic therapy (PDT) in the palliative treatment of cholangiocarcinoma. To systematically evaluate existing meta-analyses on PDT for cholangiocarcinoma, assessing evidence quality strength while performing updated to refine outcomes. PubMed, EMBASE, Cochrane Library, Web Science were searched up September 18, 2024, identify clinical patients The random-effects model was employed re-synthesize meta-analyses, comprehensive evaluation methodological quality. Updated data conducted, including subgroup analyses stratified by cholangiocarcinoma type intervention modality. A total 5 21 included. findings indicated that combining stenting or chemotherapy can significantly improve overall reduce mortality rate, without increasing risk adverse events (AEs) such as cholangitis abscess formation. For extrahepatic adding notable improvement 2-year rate. Meanwhile, hilar addition showed more pronounced enhancement 1-year Current indicates combined decreases enhances OS incidence AEs. Adding may be beneficial long-term efficacy.

Language: Английский

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The connection between climate change and perinatal mental health

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 21, 2025

Climate change and extreme weather events are particularly concerning for pregnant postpartum women have been related to negative birth outcomes. However, the impact of climate on perinatal mental health outcomes is not well studied. Mood anxiety disorders among leading comorbidities during pregnancy period, they associated with significant familial societal burdens. It crucial include environmental factors in risk profile illness optimize prevention early intervention strategies. In clinical experience one authors, new mothers can feel concerned about their baby’s physical when faced heat or may present as agitated due heat-related sleep deprivation. This line qualitative research showing maternal worrying a thermal dysregulation emerging themes. With becoming more frequent, clinicians role advocating adaptation healthcare settings. inequalities need be addressed alongside social inequalities.

Language: Английский

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Anxiety and activism in response to climate change

Current Opinion in Psychology, Journal Year: 2025, Volume and Issue: 62, P. 101996 - 101996

Published: Jan. 23, 2025

Increasing evidence for climate change is leading to increasing awareness of human impacts, including threats mental health as well social relationships. Experiencing the impacts change, such extreme weather events or wildfires, threat that presents, can lead anxiety, loss connections and support, relational challenges aggression conflict. However, also has potential increase engagement in activism designed promote an effective societal response. Activism help mitigate environmental harm well-being those involved. Further research needed understand circumstances which anxiety encourage activism, conditions limits surrounding positive on anxiety. Policies programs could be established among distressed about change.

Language: Английский

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Cancer Risk and Estimated Lithium Exposure in Drinking Groundwater in the US

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(2), P. e2460854 - e2460854

Published: Feb. 20, 2025

Lithium is a naturally occurring element in drinking water and commonly used as mood-stabilizing medication. Although clinical studies have reported associations between receiving lithium treatment reduced cancer risk among patients with bipolar disorder, to our knowledge, the association environmental exposure has never been studied general population. To evaluate groundwater This cohort study included participants electronic health record residential address information but without history at baseline from All of Us Research Program May 31, 2017, June 30, 2022. Participants were followed up until February 15, 2023. Statistical analysis was performed September 2023 through October 2024. concentration groundwater, based on kriging interpolation publicly available US Geological Survey data for 4700 wells across contiguous 12, 1999, November 6, 2018. The main outcome diagnosis or condition, obtained records. Stratified Cox proportional hazards regression models estimate hazard ratios (HRs) 95% CIs overall individual types increasing quintiles estimated adjusting socioeconomic, behavioral, neighborhood-level variables. further conducted western eastern halves restricted long-term residents living their current least 3 years. A total 252 178 (median age, 52 years [IQR, 36-64 years]; 60.1% female). median follow-up time 3.6 (IQR, 3.0-4.3 years), 7573 incident cases identified. Higher consistently associated risk. Compared first (lowest) quintile exposure, HR all cancers 0.49 (95% CI, 0.31-0.78) fourth 0.29 0.15-0.55) fifth quintile. These found investigated both females males, residents, states. For example, vs cancers, 0.17 0.07-0.42) 0.13 0.04-0.38) males; 0.32 0.15-0.66) 0.24 0.11-0.52) 0.01 0.00-0.09) states 0.34 0.21-0.57) In this participants, Given sparse evidence unknown mechanisms association, investigation warranted.

Language: Английский

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