International Journal of Bipolar Disorders,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Dec. 23, 2024
Abstract
Background
The
rate
of
suicide
attempts
by
patients
with
bipolar
disorder
is
high.
In
addition
to
patient
and
country
specific
factors,
environmental
factors
may
contribute
suicidal
behavior.
Sunlight
has
multiple
diverse
impacts
on
human
physiology
Solar
insolation
defined
as
the
electromagnetic
energy
from
sun
striking
a
surface
area
earth.
We
previously
found
that
large
change
in
solar
between
minimum
maximum
monthly
values
was
associated
an
increased
risk
I
disorder.
Methods
association
history
again
investigated
using
international
database
15%
more
data
sites
at
locations
countries.
Results
Data
were
available
5641
living
wide
range
latitudes
41
countries
both
hemispheres.
A
disorder,
replication
our
prior
analysis.
estimated
model
also
state
sponsored
religion
onset
country,
female
gender,
alcohol
or
substance
abuse,
being
part
younger
birth
cohort
attempts.
Conclusions
replicating
research.
Physicians
should
be
aware
daylight
ranging
physiological
psychiatric
impacts,
changes
risk.
Bipolar Disorders,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
ABSTRACT
Background
Individuals
with
bipolar
disorder
have
been
reported
to
increased
white
matter
hyperintensities
(WMH)
in
fluid‐attenuated
inversion
recovery
(FLAIR)
magnetic
resonance
scans.
However,
it
is
unknown
whether
this
WMH
increase
has
any
impact
on
connectivity.
The
present
study
aimed
evaluate
the
effects
of
disorder‐related
tracts
and
networks.
Methods
An
expert
neuroradiologist
blindly
assessed
type,
size,
location
from
128
FLAIR
scans
(bipolar
disorder:
n
=
64,
age
38
±
7
years;
53%
females;
matched
healthy
controls:
36
10
years,
58%
females).
Afterward,
we
conducted
an
atlas‐based
analysis
comparing
mean
percentage
parcel
damage
Human
Connectome
Project
tractography
template
networks
7‐Network
Cortical
Parcellation
template.
Results
We
did
not
detect
WMH‐related
connectivity
when
correcting
for
multiple
comparisons.
at
uncorrected
level,
found
a
higher
disconnection
right
inferior
fronto‐occipital
fasciculus
middle
longitudinal
fasciculus.
Conclusion
This
evaluates,
first
time,
brain
structural
It
finds
effect
two
fasciculi,
providing
hints
into
one
potential
origin
networks'
alterations
disorder.
only
observed
these
results
statistical
which
they
are
likely
small
should
be
taken
caution
until
replicated.
Current Psychiatry Reports,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
Abstract
Purpose
of
Review
This
paper
explores
Predominant
Polarity
(PP)
in
Bipolar
Disorder
(BD),
defined
as
the
predominance
either
manic
or
depressive
episodes
over
a
patient’s
course
illness.
We
examine
its
clinical
relevance,
neurobiological
foundations,
and
potential
for
guiding
personalized
treatment
strategies.
The
review
seeks
to
determine
whether
PP
is
reliable
specifier
how
it
can
be
utilized
improve
outcomes.
Recent
Findings
has
significant
impact
on
prognosis
planning
BD.
Manic
are
associated
with
distinct
profiles
BD,
while
individuals
without
clear
episode
type
represent
more
severe
to-treat
subgroup
patients.
development
Index
(PI)
facilitates
decisions
based
PP.
Summary
offers
valuable
framework
refining
BD
understanding
complexity.
Future
research
should
focus
definitions,
validating
markers,
integrating
these
insights
into
comprehensive
models
patient
