Scientia Sinica Chimica, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Biology, Journal Year: 2024, Volume and Issue: 13(6), P. 391 - 391
Published: May 29, 2024
Methyltransferases are a wide-ranging, yet well-conserved, class of molecules that have been found to modify wide variety substrates. Interest in RNA methylation has surged recent years with the identification major eukaryotic mRNA m6A methyltransferase METTL3. METTL16 also identified as an methyltransferase; however, much less is known about its targets and actions. Interestingly, addition their catalytic activities, both METTL3 “methylation-independent” functions, including translational regulation, which discovered. However, evidence suggests METTL16’s role RNA-binding protein may be more significant than currently recognized. In this review, we will introduce methylation, specifically m6A, enzymes responsible for deposition. We discuss varying roles these perform delve deeper into possible methylation-independent binding proteins. Finally, touch upon many open questions still remaining.
Language: Английский
Citations
5
Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)
Published: Feb. 3, 2025
N6-methyladenosine (m6A) RNA modifications have emerged as crucial epigenetic regulators in various biological processes, including spermatogenesis. This review aims to elucidate the role of m6A spermatogenesis and their implications for male infertility, particularly non-obstructive azoospermia (NOA). We conducted a comprehensive recent studies focusing on methyltransferases, demethylases, reader proteins involved Our analysis reveals that play vital regulating mRNA stability, translation efficiency, splicing, RNA–protein interactions during Key such METTL3, METTL14, ALKBH5, YTHDF are critical proper spermatogenic function. Abnormalities these regulators, due genetic mutations, expression dysregulation, or environmental factors, linked impaired NOA. Studies also indicate significant dysregulation m6A-related genes NOA patients, suggesting potential diagnostic therapeutic target infertility. integral regulation fertility. Further research is needed fully understand mechanisms by which influence explore interventions. highlights importance reproductive health underscores need continued investigation this emerging field.
Language: Английский
Citations
0
European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 994, P. 177397 - 177397
Published: Feb. 18, 2025
Language: Английский
Citations
0
Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115471 - 115471
Published: March 25, 2025
Language: Английский
Citations
0
Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 53(D1), P. D310 - D317
Published: Nov. 5, 2024
We present Sci-ModoM, the first next-generation RNome database offering a holistic view of epitranscriptomic landscape. Sci-ModoM has simple yet powerful interface, underpinned by FAIR data principles, standardized nomenclature, and interoperable formats, fostering use common standards within epitranscriptomics community. provides quantitative measurements per site dataset, enabling users to assess confidence levels based on score, coverage, stoichiometry. Data in is directly traceable its sources. Users can Search Compare over six million modifications across 156 datasets, Browse or download retrieve metadata. A comparison tool offers novel unique opportunity compare site-wise with ability securely upload user against latest published research. empowers researchers, including non-experts, access broad spectrum recent RNA modification data, thereby enhancing utility impact discoveries, opening new avenues biological medical
Language: Английский
Citations
2
Oncology Reports, Journal Year: 2024, Volume and Issue: 52(5)
Published: Aug. 23, 2024
Language: Английский
Citations
1
Molecular Therapy — Nucleic Acids, Journal Year: 2024, Volume and Issue: 35(4), P. 102391 - 102391
Published: Nov. 15, 2024
RNA modifications play a crucial role in regulating gene expression by altering structure and modulating interactions with RNA-binding proteins (RBPs). In this study, we explore the impact of specific chemical modifications-N
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 31, 2024
Abstract RNA modifications play a crucial role in regulating gene expression by altering structure and modulating interactions with RNA-binding proteins (RBPs). In this study, we explore the impact of specific chemical modifications—N6-methyladenosine (m⁶A), A-to-I editing, pseudouridine (Ψ)—on secondary protein-RNA interactions. Utilizing genome-wide data, including predictions interaction datasets, classify into distinct categories based on their binding behaviors: modification-specific structure-independent, or modification-promiscuous structure-dependent. For instance, m⁶A readers like YTHDF2 exhibit structure-independent binding, consistently attaching to regardless structural changes. Conversely, such as U2AF2 display structure-dependent behavior, preferences response changes induced different modifications. which causes significant changes, typically reduces protein interactions, while Ψ enhances stability, albeit variable effects binding. To better predict these developed catRAPID 2.0 algorithm, forecasts propensities. This algorithm serves valuable tool for researchers, enabling prediction analysis modifications’ thus offering new insights biology engineering. The is available at http://service.tartaglialab.com/new_submission/catrapid_omicsv2_rna_mod . Figure
Language: Английский
Citations
0
Scientia Sinica Chimica, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Citations
0