Regioselective Access to Substituted Benzothiophenes/furans through Electrochemical Selenium-Promoted Skeletal Rearrangement DOI
Debabrata Maiti, Atreyee Halder, Anushree Saha

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: 27(4), P. 961 - 966

Published: Jan. 21, 2025

An electrochemical strategy for the regioselective construction of seleno-benzothiophenes/furans is reported through selenocyclization, followed by Wagner-Meerwein rearrangement. This electro-oxidative tandem process operates under metal-free and external chemical oxidant-free conditions. Advantageously, unprotected homopropargyl alcohols were found to be compatible reaction conditions, releasing water dihydrogen as biproduct. methodology reveals good functional group tolerance, allowing a broad spectrum substrate scopes up 87% isolated yield.

Language: Английский

Regioselective Access to Substituted Benzothiophenes/furans through Electrochemical Selenium-Promoted Skeletal Rearrangement DOI
Debabrata Maiti, Atreyee Halder, Anushree Saha

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: 27(4), P. 961 - 966

Published: Jan. 21, 2025

An electrochemical strategy for the regioselective construction of seleno-benzothiophenes/furans is reported through selenocyclization, followed by Wagner-Meerwein rearrangement. This electro-oxidative tandem process operates under metal-free and external chemical oxidant-free conditions. Advantageously, unprotected homopropargyl alcohols were found to be compatible reaction conditions, releasing water dihydrogen as biproduct. methodology reveals good functional group tolerance, allowing a broad spectrum substrate scopes up 87% isolated yield.

Language: Английский

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