Protection against Cholinesterase and Oxidative Stress Contributes to The Effect of Rutin ameliorating Ethanol-Induced Memory Dysfunction in Rats DOI Open Access
Shaktipal Patil, Amrapali Mhaiskar,

Ujwal Katolkar

et al.

American Journal of PharmTech Research, Journal Year: 2019, Volume and Issue: 9(3), P. 16 - 35

Published: June 8, 2019

Ethanol-induced memory impairment in rats is a consequence of changes within the central nervous system that are secondary to impaired oxidative stress and cholinergic dysfunction.Treatment with antioxidants agonists reported produce beneficial effects animal models.Rutin exhibit antioxidant effect cholinesterase (ChE) inhibitor activity.However, no report available on influence rutin ethanol-induced impairment.Therefore, we tested its against cognitive dysfunction using Morris water maze test Novel object recognition test.Lipid peroxidation glutathione levels as parameter ChE activity marker function were assessed cerebral cortex hippocampus.Forty five days after ethanol treated showed severe deficit learning associated increased lipid peroxidation, decreased glutathione, elevated activity.In contrast, chronic treatment (20-80 mg/kg, p.o., once day for 45 days) vitamin C (100 p.o.) improved performance, lowered rats.In conclusion, present study demonstrates prevents activity, consequently rats.

Language: Английский

The Central Amygdala and Alcohol: Role of -Aminobutyric Acid, Glutamate, and Neuropeptides DOI Open Access
Marisa Roberto, Nicholas W. Gilpin,

George R. Siggins

et al.

Cold Spring Harbor Perspectives in Medicine, Journal Year: 2012, Volume and Issue: 2(12), P. a012195 - a012195

Published: Oct. 19, 2012

Alcohol dependence is a chronically relapsing disorder characterized by compulsive drug seeking and taking, loss of control in limiting intake, the emergence withdrawal syndrome absence drug. Accumulating evidence suggests an important role for synaptic transmission central amygdala (CeA) mediating alcohol-related behaviors neuroadaptative mechanisms associated with alcohol dependence. Acute facilitates γ-aminobutyric acid-ergic (GABAergic) CeA via both pre- postsynaptic mechanisms, chronic increases baseline GABAergic transmission. inhibits glutamatergic effects at N-methyl-d-aspartate (NMDA) AMPA receptors CeA, whereas up-regulates receptor (NMDAR)-mediated Pro- (e.g., corticotropin-releasing factor [CRF]) anti-stress NPY, nociceptin) neuropeptides affect alcohol- anxiety-related behaviors, also alter alcohol-induced on neurotransmission. produces plasticity these neuropeptide systems, reflecting recruitment those systems during transition to

Language: Английский

Citations

128
Alcohol use disorder: pathophysiology, effects, and pharmacologic options for treatment DOI Creative Commons

Peter Clapp,

Robin C. Wackernah,

Matthew Minnick

et al.

Substance Abuse and Rehabilitation, Journal Year: 2014, Volume and Issue: unknown, P. 1 - 1

Published: Jan. 1, 2014

Abstract: Alcohol use disorders (AUD) continue to be a concerning health issue worldwide. Harmful alcohol leads 2.5 million deaths annually Multiple options exist for the management of dependence on alcohol, not all which are approved by drug-regulating agencies. Current practice in treating AUD does reflect diversity pharmacologic that have potential provide benefit, and guidance clinicians is limited. Few medications treatment AUD, these exhibited small and/or inconsistent effects broad patient populations with diverse drinking patterns. The need continued research into this disease evident order patients more specific effective options. This review describes neurobiological mechanisms amenable drug therapies target pathophysiological conditions reduce drinking. In addition, current literature (both non-approved) offered United States elsewhere reviewed. aim inform regarding abuse treatment, keeping mind treatments completely successful reducing craving or heavy increasing abstinence. Keywords: abuse, alcoholism, craving, dependence, relapse

Language: Английский

Citations

52
Synchrony between midbrain gene transcription and dopamine terminal regulation is modulated by chronic alcohol drinking DOI Creative Commons
Zahra Z. Farahbakhsh, Katherine M. Holleran, Jonathon Sens

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 25, 2025

Abstract Alcohol use disorder is marked by disrupted behavioral and emotional states which persist into abstinence. The enduring synaptic alterations that remain despite the absence of alcohol are interest for interventions to prevent relapse. Here, 28 male rhesus macaques underwent over 20 months drinking interspersed with three 30-day forced abstinence periods. After last period, we paired direct sub-second dopamine monitoring via ex vivo voltammetry in nucleus accumbens core RNA-sequencing ventral tegmental area. We found persistent augmentation transporter function, kappa opioid receptor sensitivity, putative dynorphin release – all inhibitory regulators act decrease extracellular dopamine. Surprisingly, though transcript expression was not altered, relationship between gene functional readouts these encoded proteins highly dynamic altered history. These results outline long-lasting impact suggest assessment transcript-function relationships critical rational design precision therapeutics.

Language: Английский

Citations

0
Anterior and Posterior Basolateral Amygdala Projections of Cell Type–Specific D1-Expressing Neurons From the Medial Prefrontal Cortex Differentially Control Alcohol-Seeking Behavior DOI
Ziyi Li, Jiaxin Li,

Yanxia Wei

et al.

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(10), P. 963 - 973

Published: Nov. 10, 2023

Language: Английский

Citations

6
Consumo de alcohol en la adolescencia. Consideraciones médicas y orientaciones educativas DOI Creative Commons

Francisco David Rodríguez García,

María Luisa Sanchiz Ruiz,

Rafael Bisquerra Alzina

et al.

Salud Mental, Journal Year: 2014, Volume and Issue: 37(3), P. 255 - 255

Published: Jan. 1, 2014

El consumo de alcohol por parte los adolescentes supera en España el otras sustancias psicoactivas. Los daños que cerebro humano sufre a causa del etanol, especialmente la etapa adolescencia, son objeto muchos estudios y se centran principalmente cómo afecta neurotransmisión. Además, vulnerabilidad influencia ofrece rasgos peculiares cuanto encuentra una intensa actividad remodelación sináptica. Es necesario unir fuerzas, conocimientos recursos dirigidos un mejor conocimiento, tanto efectos biológicos individuo adolescente como derivados ámbitos emocional, social familiar, para diseñar actuaciones educativas faciliten modificación o erradicación hábitos no saludables relacionados con ingesta alcohol. La evaluación previa dirige promover calidad vida Educación Secundaria, crucial desarrollo global ser humano.

Citations

9
Reducing the harms of alcohol: nutritional interventions and functional alcohol alternatives DOI
Delia Belelli, Antonio Riva, David Nutt

et al.

International review of neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 241 - 276

Published: Jan. 1, 2024

Language: Английский

Citations

0
Chronic alcohol induces subcircuit-specific striatonigral plasticity shifting action control to the sensorimotor striatum DOI Open Access
Giacomo Sitzia, Sebastiano Bariselli, Alexa L. Gracias

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 15, 2023

Abstract While cortico-striatal circuit deficits contribute to Alcohol Use Disorder, the impact of alcohol on synaptic function in basal ganglia output, substantia nigra pars reticulata (SNr), remains unclear. Here, we found that inputs from dorsomedial (DMS) and dorsolateral striatum (DLS) differ their presynaptic properties target molecularly distinct subpopulations SNr neurons. We also discovered indirect pathway subthalamic (STN) medial lateral have different STN are stronger SNr. Chronic exposure (CIE) potentiated DLS but did not affect strength release DMS Chemogenetic inhibition direct projection neurons impaired action performance an operant conditioning task CIE mice control mice. Overall, our work identifies a mechanism whereby chronic induces gain for striatum. Teaser selectively potentiates SNr, enhancing role control.

Language: Английский

Citations

1
Synchrony between midbrain gene transcription and dopamine terminal regulation is modulated by chronic alcohol drinking DOI Open Access
Zahra Z. Farahbakhsh, Katherine M. Holleran, Jonathon Sens

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 17, 2024

Alcohol use disorder is marked by disrupted behavioral and emotional states which persist into abstinence. The enduring synaptic alterations that remain despite the absence of alcohol are interest for interventions to prevent relapse. Here, 28 male rhesus macaques underwent over 20 months drinking interspersed with three 30-day forced abstinence periods. After last period, we paired direct sub-second dopamine monitoring via

Language: Английский

Citations

0
MicroRNAs as biomarkers in alcohol use disorder: from diagnostics to therapy. Review of literature DOI Creative Commons
Anna Mach, Grażyna Gromadzka

Alcoholism and Drug Addiction, Journal Year: 2020, Volume and Issue: 33(4), P. 313 - 340

Published: Jan. 1, 2020

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Mach A, Gromadzka G. MicroRNAs as biomarkers in alcohol use disorder: from diagnostics to therapy. Review of literature. Alcoholism and Drug Addiction/Alkoholizm i Narkomania. 2020;33(4):313-340. doi:10.5114/ain.2020.104815. APA Mach, A., & Gromadzka, (2020). Narkomania, 33(4), 313-340. https://doi.org/10.5114/ain.2020.104815 Chicago Anna, Grażyna Gromadzka. 2020. "MicroRNAs literature". Narkomania 33 (4): Harvard pp.313-340. MLA Anna et al. literature." vol. 33, no. 4, 2020, pp. Vancouver

Language: Английский

Citations

2
Treatment of Methamphetamine Withdrawal with Methylphenidate and Modafinil DOI Open Access
Jamshid Ahmadi,

Adnan Ahmadiazad,

Zahra Noorbakhsh

et al.

Published: Sept. 7, 2022

The most common cause of substance use disorders is psychiatric disease.A significant number people self-medicate to decrease or improve their mental such as irritability, anxiety, agitation, depression, mania, aggression, exhaustion, insomnia, impotency, and pain.Considering increasing level problems globally, related diseases, especially mainly stimulants induced have been considered progressing dilemma .At present, outpatient inpatient referrals resulted from abuse are going up .Use methamphetamine produces a state well-being accompanied with enhanced energy, wakefulness, physical activity [1,111].Repeatedly extended results driven drug abuse, reduced weight, increased violence, memory deficits, poor impulse control, low concentration, prolonged health consequences, severe dependency, unstable mood affect, delusions hallucinations [112,113].Methamphetamine universally abused.

Language: Английский

Citations

1