The Scientific World JOURNAL,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 15
Published: March 11, 2022
The
utilization
of
microbial
pectinase
in
different
industries
has
been
increased
its
world
demand.
major
sources
are
microorganisms
mainly
bacteria,
fungi
and
yeast.
low-cost
agro-industrial
wastes
as
substrates
preferable
production.
Pectinase
production
faced
various
parameters
optimization
constraints
such
temperature,
pH
times
which
the
main
factors
enzyme
is
getting
attention
due
to
several
advantages;
hence,
it
needs
be
explored
further
take
maximum
advantage
industries.
This
review
discusses
pectin
substance
structure,
substrate
for
production,
influencing
industrial
application
also
challenges
future
opportunities
applying
industry.
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
19, P. 100560 - 100560
Published: Jan. 21, 2023
Filamentous
fungi
drive
carbon
and
nutrient
cycling
across
our
global
ecosystems,
through
its
interactions
with
growing
decaying
flora
their
constituent
microbiomes.
The
remarkable
metabolic
diversity,
secretion
ability,
fiber-like
mycelial
structure
that
have
evolved
in
filamentous
been
increasingly
exploited
commercial
operations.
industrial
potential
of
fermentation
ranges
from
the
discovery
bioproduction
enzymes
bioactive
compounds,
decarbonization
food
material
production,
to
environmental
remediation
enhanced
agricultural
production.
Despite
fundamental
impact
ecology
biotechnology,
molds
mushrooms
not,
to-date,
significantly
intersected
synthetic
biology
ways
comparable
other
cell
factories
(e.g.
Escherichia
coli,Saccharomyces
cerevisiae,
Komagataella
phaffii).
In
this
review,
we
summarize
a
suite
computational
tools
for
mining,
engineering
optimization
as
chassis.
A
combination
methods
genetic
engineering,
mutagenesis,
experimental
evolution,
modeling
can
be
used
address
strain
development
bottlenecks
established
emerging
industries.
These
include
slow
mycelium
growth
rate,
low
production
yields,
non-optimal
alternative
feedstocks,
difficulties
downstream
purification.
scope
biomanufacturing,
then
detail
previous
efforts
improving
key
by
targeting
protein
processing
pathways,
hyphae
morphogenesis,
transcriptional
control.
Bringing
practices
into
hidden
world
will
serve
expand
limited
panel
host
organisms
allow
commercially-feasible
environmentally-sustainable
enzymes,
chemicals,
therapeutics,
foods,
materials
future.
Annual Review of Food Science and Technology,
Journal Year:
2023,
Volume and Issue:
15(1), P. 173 - 187
Published: Dec. 22, 2023
Animal-based
agriculture
and
the
production
of
protein-rich
foods
from
animals,
particularly
ruminants,
are
not
sustainable
have
serious
climate
effects.
A
new
type
alternative
proteins
is
now
on
menu,
namely
animal
produced
recombinantly
by
microbial
fermentation.
This
technology,
precision
fermentation,
projected
to
completely
disrupt
traditional
animal-based
agriculture.
Certain
milk
egg
along
with
specific
meat
substitute
analog
components
fermentation
already
entering
market.
first
wave
products
targets
use
these
as
protein
additives,
several
commercial
players
active
in
field.
The
cost-efficiency
requirements
involve
titers
above
50
g/L
which
orders
magnitude
higher
than
those
for
pharmaceutical
manufacture,
making
strain
engineering,
process
optimization,
scale-up
critical
success
factors.
development
within
defines
a
research
direction
integrating
biotechnology,
food
production.
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: July 24, 2024
Abstract
A
major
roadblock
towards
the
realisation
of
a
circular
economy
are
lack
high-value
products
that
can
be
generated
from
waste.
Black
soldier
flies
(BSF;
Hermetia
illucens
)
gaining
traction
for
their
ability
to
rapidly
consume
large
quantities
organic
wastes.
However,
these
primarily
used
produce
small
variety
products,
such
as
animal
feed
ingredients
and
fertiliser.
Using
synthetic
biology,
BSF
could
developed
into
novel
sustainable
biomanufacturing
platform
valorise
broader
waste
feedstocks
enhanced
feeds,
biomolecules
including
industrial
enzymes
lipids,
improved
Applied Microbiology and Biotechnology,
Journal Year:
2024,
Volume and Issue:
108(1)
Published: Jan. 10, 2024
Application
of
filamentous
fungi
for
the
production
commercial
enzymes
such
as
amylase,
cellulase,
or
xylanase
is
on
rise
due
to
increasing
demand
degrade
several
complex
carbohydrates
raw
material
biotechnological
processes.
Also,
protein
by
food
and
feed
gains
importance.
In
any
case,
involves
both
cellular
synthesis
secretion
outside
cell.
Unfortunately,
proteins
can
be
hampered
accumulation
unfolded
misfolded
in
endoplasmic
reticulum
(ER)
a
result
too
high
(heterologous)
expression.
To
cope
with
this
ER
stress,
cell
generates
response
known
(UPR).
Even
though
mechanism
should
re-establish
homeostasis
equivalent
under
non-stress
conditions,
enzyme
expression
might
still
suffer
from
repression
secretory
stress
(RESS).
Among
eukaryotes,
Saccharomyces
cerevisiae
only
fungus,
which
studied
quite
extensively
unravel
UPR
pathway.
Several
homologs
involved
signal
transduction
cascade
are
also
found
fungi.
Since
RESS
seems
absent
S.
was
reported
Trichoderma
reesei
presence
folding
glycosylation
inhibitors
dithiothreitol
tunicamycin,
more
in-depth
study
about
mechanism,
specifically
fungi,
need
hour.
Hence,
review
article
gives
an
overview
both,
associated
responses
KEY
POINTS:
•
Enzymes
produced
crucial
industrial
processes
conserved
among
many
but
mediated
different
not
fully
understood
industrially
relevant
