Metabolites,
Journal Year:
2024,
Volume and Issue:
14(4), P. 236 - 236
Published: April 19, 2024
This
study
evaluated
effects
of
high
starch
(20%)
on
hematological
variations,
glucose
and
lipid
metabolism,
antioxidant
ability,
inflammatory
responses,
histopathological
lesions
in
largemouth
bass.
Results
showed
hepatic
crude
triacylglycerol
(TAG)
contents
were
notably
increased
fish
fed
starch.
High
could
increase
counts
neutrophils,
lymphocytes,
monocytes,
eosinophils,
basophils
serum
TAG,
TBA,
BUN,
LEP
(
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
252, P. 114589 - 114589
Published: Jan. 30, 2023
Selenium
plays
a
vital
role
in
cancer
prevention,
antioxidation,
and
the
growth
of
humans
other
vertebrates.
Excessive
selenium
can
cause
liver
injury
metabolic
disorders,
which
lead
to
hepatic
disease,
but
few
studies
have
shown
effects
excessive
on
development
its
mechanism
zebrafish
embryos.
In
this
study,
glucolipid
metabolism
were
investigated
selenium-stressed
Under
treatment,
transgenic
fabp10a-eGFP
embryos
showed
reduced
size,
wild-type
exhibited
steatosis
altered
lipid
metabolism-related
indexes
glucose
enzyme
activities.
addition,
damaged
mitochondria
inhibited
autophagy
liver.
An
inducer
(rapamycin)
alleviated
selenium-induced
restored
expression
some
genes
related
metabolism.
summary,
our
research
evaluated
developmental
toxicity
disorders
under
stress,
confirmed
that
oxidative
stress
might
involve
defects.
Animal nutrition,
Journal Year:
2024,
Volume and Issue:
17, P. 11 - 24
Published: Jan. 3, 2024
Fibroblast
growth
factor
1
(FGF1)
regulates
vertebrate
cell
growth,
proliferation
and
differentiation,
energy
metabolism.
In
this
study,
we
cloned
rainbow
trout
(Oncorhynchus
mykiss)
fgf1
fgf1a,
prepared
their
recombinant
proteins
(rFGF1
rFGF1a),
described
the
molecular
mechanisms
by
which
they
improve
glycolipid
metabolism
in
carnivorous
fish.
A
31-day
feeding
trial
was
conducted
to
investigate
whether
could
enhance
on
high-carbohydrate
diets
(HCD).
The
720
(8.9
±
0.5
g)
were
equally
divided
into
four
groups:
chow
diet
(CD)
group
received
PBS,
HCD
rFGF1
(400
ng/g
body
weight),
rFGF1a
weight).
results
showed
that
short-term
had
a
significant
positive
effect
specific
rate
(SGR)
of
(P
<
0.05).
However,
it
led
an
increase
crude
fat,
serum
triglyceride
(TG)
glucose
content,
as
well
glutamic
pyruvic
transaminase
(GPT)
oxalacetic
(GOT)
contents
0.05),
suggesting
negative
health
HCD.
Nevertheless,
beneficial
therapeutic
effects.
They
significantly
reduced
fat
content
liver,
TG,
GOT,
GPT
caused
upregulation
atgl,
hsl,
acc2
mRNAs
implied
promotion
TG
catabolism.
Moreover,
contributed
promoting
lipolysis
activating
AMPK
pathway
reducing
lipid
accumulation
liver
addition,
rFGF1a-treated
groups
levels
elevated
hepatic
glycogen
under
HCD,
increased
uptake
hepatocytes.
We
observed
decrease
mRNA
for
pepck,
g6pase,
pygl,
along
with
gys,
glut2,
gk
liver.
Furthermore,
these
regulate
gluconeogenesis
synthesis
increasing
phosphorylation
level
AKT,
ultimately
leading
GSK3β
phosphorylation.
conclusion,
study
demonstrates
can
utilization
AKT/GSK3β
axis.
Metabolites,
Journal Year:
2024,
Volume and Issue:
14(4), P. 236 - 236
Published: April 19, 2024
This
study
evaluated
effects
of
high
starch
(20%)
on
hematological
variations,
glucose
and
lipid
metabolism,
antioxidant
ability,
inflammatory
responses,
histopathological
lesions
in
largemouth
bass.
Results
showed
hepatic
crude
triacylglycerol
(TAG)
contents
were
notably
increased
fish
fed
starch.
High
could
increase
counts
neutrophils,
lymphocytes,
monocytes,
eosinophils,
basophils
serum
TAG,
TBA,
BUN,
LEP
(
