Clinical Rheumatology, Journal Year: 2024, Volume and Issue: 44(1), P. 425 - 432
Published: Dec. 17, 2024
Language: Английский
Inflammation Research, Journal Year: 2024, Volume and Issue: 73(4), P. 655 - 667
Published: March 15, 2024
Language: Английский
Citations
34
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 22, 2024
Introduction Our objective was to explore the potential link between systemic inflammation response index (SIRI) and chronic kidney disease (CKD). Methods The data used in this study came from National Health Nutrition Examination Survey (NHANES), which gathers 1999 2020. CKD diagnosed based on low estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m 2 or albuminuria (urinary albumin-to-creatinine ratio (ACR) more 30 mg/g). Using generalized additive models weighted multivariable logistic regression, independent relationships SIRI other inflammatory biomarkers (systemic immune-inflammation (SII), monocyte/high-density lipoprotein (MHR), neutrophil/high-density (NHR), platelet/high-density (PHR), lymphocyte/high-density (LHR)) with CKD, albuminuria, low-eGFR were examined. Results Among recruited 41,089 participants, males accounted for 49.77% total. Low-eGFR, prevalent 8.30%, 12.16%, 17.68% people, respectively. shown be positively correlated (OR = 1.24; 95% CI: 1.19, 1.30). Furthermore, a nonlinear correlation discovered CKD. are both two sides breakpoint (SIRI 2.04). Moreover, increased levels associated greater prevalences (albuminuria: OR 1.27; 1.21, 1.32; low-eGFR: 1.11; 1.05, 1.18). ROC analysis demonstrated that, compared indices (SII, NHR, LHR, MHR, PHR), exhibited superior discriminative ability accuracy predicting low-eGFR. Discussion When low-eGFR, may show up as biomarker when PHR). American adults elevated SIRI, SII, PHR should attentive risks their health.
Language: Английский
Citations
25
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: April 8, 2024
Background systemic inflammation disorders were observed in chronic kidney disease (CKD). Whether the inflammatory indicators could be optimal predictors for survival of CKD remains less studied. Methods In this study, participants selected from datasets National Health and Nutrition Examination Survey (NHANES) between 1999 to 2018 years. Four evaluated by peripheral blood tests including immune-inflammation index (SII, platelet*neutrophil/lymphocyte), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR). Kaplan-Meier curves, restricted cubic spline (RCS), Cox regression analysis used evaluate association with all-cause mortality CKD. Receiver operating characteristic (ROC) concordance (C-index) determine predictive accuracy varied indicators. Sensitive analyses conducted validate robustness main findings. Results A total 6,880 included study. The mean age was 67.03 years old. Among study population, levels 588.35 SII, 2.45 NLR, 133.85 PLR, 3.76 LMR, respectively. PLR all significantly positively associated patients, whereas high value LMR played a protectable role patients. NLR leading patients [Hazard (HR) =1.21, 95% confidence interval (CI): 1.07-1.36, p = 0.003 (3 rd quartile), HR 1.52, 95%CI: 1.35-1.72, p<0.001 (4 th quartile) 0.83, 0.75-0.92, (2 nd 0.73, 0.65-0.82, 0.74, 0.65-0.83, LMR], C-index 0.612 0.624, RCS curves showed non-linearity risk population. Conclusion Our highlights that are important predicting U.S. population would add additional clinical health care
Language: Английский
Citations
23
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 11
Published: Jan. 10, 2024
Inflammation and obesity have been widely recognized to play a key role in Diabetes mellitus (DM), there exists complex interplay between them. We aimed clarify the relationship inflammation DM, as well mediating of relationship.
Language: Английский
Citations
18
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 9, 2025
Severe obesity is often associated with inflammation and insulin resistance (IR), which expected to increase the risks of mortality cancers. However, this relationship remains controversial, it's unclear whether healthy lifestyles can mitigate these risks. The independent joint associations severe (body mass index ≥ 35 m/kg2), (C-reactive protein > 10 mg/L systemic markers 9th decile), IR surrogates all-cause all-site cancers, were evaluated in 163,008 participants from UK Biobank cohort. Further analyses conducted investigate how modified by lifestyle. During a median follow-up 11.0 years, we identified 8844 deaths 20,944 cancer cases. obesity, each independently increased [HRs(95%CIs) 1.24(1.17–1.30), 1.63(1.55–1.72) 1.11(1.05–1.17)] cancers [1.06(1.02–1.10), 1.14(1.10–1.19) 1.02(0.99–1.06)]. Joint revealed significantly elevated due interaction between IR, highest HRs(95%CIs) 1.88(1.67–2.11) 1.20(1.08–1.34), respectively. showed stronger inflammation, lifestyles, similar observed both males females. Additionally, compared unfavorable favorable attenuated [the 2.35(1.75–3.15) vs. 3.72(2.86–4.84) for lifestyles] [1.16(0.89–1.53) 1.63(1.26–2.10)]. interacts exacerbate Nonetheless, adherence recommended
Language: Английский
Citations
2
Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10
Published: May 18, 2023
As a composite immunonutritional biomarker, the Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) score has shown promise in assessing patient's overall health status by integrating several routinely collected laboratory indicators. This biomarker been examined many different populations of patients and disease states (i.e., cancer), but an integrated, universal rubric using standardized thresholds not thus far developed. Pre-existing large population-based databases represent ideal source to examine distribution HALP influence diverse statuses on this score.We conducted cross-sectional study data from National Health Nutrition Examination Survey (NHANES) between 2017-2020, evaluating 8,245 participants across numerous demographic, socioeconomic, health-related variables. Univariate multivariate linear regression analyses assessed associations scores these factors.Our findings revealed significant various conditions. The median among representative population was 49.0, with varying groups normal reference ranges for males females. Multivariate analysis showed that anemia treatment, age over 65 years, weak/failing kidneys, cancer were independent risk factors associated lower scores. Male demonstrated higher than female participants, inversely related HALP. Moreover, negatively number comorbidities.This set out explore perspective, uncovering notable offer vital insights into score's clinical relevance future applications. By determining 49.0 within our diverse, sample, we establish robust foundation researchers refine optimal applications thresholds. Considering growing focus personalized medicine, holds as prognostic tool, enabling clinicians comprehend their patients' better deliver customized care.
Language: Английский
Citations
22
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(2), P. e0292646 - e0292646
Published: Feb. 8, 2024
Systemic immune-inflammation index (SII) is a new indicator of inflammation, and chronic kidney disease (CKD) has connection to inflammation. However, the relationship between SII CKD still unsure. The aim this study was whether there an association in adult US population.
Language: Английский
Citations
9
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 21, 2024
Objectives The systemic immune-inflammation index (SII), a novel and systematic inflammatory biomarker that is associated with chronic kidney disease (CKD), has not received much attention. This study aimed to investigate the relationship between SII CKD in United States (U.S.) population. Methods Our ultimately included nationally representative sample of 10,787 adults who participated 2007-2018 National Health Nutrition Examination Survey. Weighted multivariate logistic regression was used assess correlation CKD, restricted cubic spline (RCS) model subsequently explore non-linear CKD. Subgroup analyses were performed further effects other covariates on Results Following confounder adjustment, higher related incidence (OR =1.36; 95% CI, 1.07–1.73; p =0.01), as validated by multivariable regression. RCS curve revealed positive SII/1000 ( for =0.0206). Additionally, subgroup analysis confirmed stronger male participants =2.628; 1.829-3.776) than female =1.733; 1.379-2.178) interaction =0.046). Conclusions positively among U.S. adults, especially males. However, studies are needed confirm our findings causal factors can contribute prevention treatment
Language: Английский
Citations
9
Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15
Published: April 23, 2024
Background A novel inflammatory marker that measures the degree of systemic immunoinflammation, immuno-inflammation index (SII) is frequently used to forecast a number illnesses. According earlier studies, inflammation may play role in pathophysiology hearing loss (HL). Methods sample from National Health and Nutrition Examination Survey (NHANES) covering years 2009 2018 was current cross-sectional survey. Subgroup analysis weighted multiple linear regression models were examine independent correlation between SII HL. Fitted smoothed curve analyses also conducted show non-linear relationship two variables. Results Among 8,535 participants, mean age 40.92 ± 18.6 years, with 49.01% being male. Notably, individuals demonstrated an 530.00 320.72, while those normal displayed 491.21 265.15. The SD values low-frequency, speech-frequency, high-frequency Pure Tone Average (PTA) thresholds 10.33 9.79, 12.20 11.11, 22.48 19.49 dB, respectively. positive dose–response higher observed after adjusting for potential confounders. Furthermore, interaction did not reveal any significant impact on this correlation. Conclusion results our investigation suggest Systemic Inflammatory Index serve as biomarker likelihood loss. However, additional research required further elucidate nature association.
Language: Английский
Citations
7
Endocrine, Journal Year: 2023, Volume and Issue: 84(2), P. 399 - 411
Published: Dec. 4, 2023
Abstract Purpose There have been limited studies examining the prospective association between Systemic Immune-Inflammation Index (SII), a novel inflammatory marker, and mortality among individuals with diabetes in United States. Methods We utilized data from National Health Nutrition Examination Survey (NHANES), representative sample of US adults, linked information Death Index. Results Our study included 8697 NHANES spanning years 1999 to 2018. SII was calculated by dividing platelet count neutrophil then that result lymphocyte count. employed multivariable Cox proportional hazards regression analysis investigate associations levels all-cause as well cause-specific mortality, while adjusting for potential confounding factors. were categorized into quartiles based on population distribution. Over median follow-up period 94.8 months (with maximum 249 months), we observed total 2465 deaths, 853 deaths cardiovascular causes, 424 cancer, 88 related chronic kidney disease. After multiple variables, higher significantly non-linearly associated an increased risk Quartile 4 (HR 1.74, 95% CI 1.15–2.63, P trend = 0.043) when 1 used reference group. Additionally, identified linear 70% 1.70, 1.18–3.30, 0.041) compared 1. Conclusion findings indicate is elevated adults diabetes.
Language: Английский
Citations
12