Bubble‐Based Microrobots with Rapid Circular Motions for Epithelial Pinning and Drug Delivery

Small, Journal Year: 2023, Volume and Issue: 19(32)

Published: April 14, 2023

Remotely powered microrobots are proposed as next-generation vehicles for drug delivery. However, most swim with linear trajectories and lack the capacity to robustly adhere soft tissues. This limits their ability navigate complex biological environments sustainably release drugs at target sites. In this work, bubble-based geometries shown efficiently non-linear in a mouse bladder, pin epithelium, slowly therapeutic drugs. The asymmetric fins on exterior bodies of induce rapid rotational component swimming motions up ≈150 body lengths per second. Due fast speeds sharp fins, can mechanically themselves bladder epithelium endure shear stresses commensurate urination. Dexamethasone, small molecule used inflammatory diseases, is encapsulated within polymeric microrobots. sustained temper inflammation manner that surpasses performance free controls. system provides potential strategy use large volumes, tissue boundaries, over several days range diseases.

Language: Английский

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Gastrointestinal digestion of food proteins: Anticancer, antihypertensive, anti-obesity, and immunomodulatory mechanisms of the derived peptides

Food Research International, Journal Year: 2024, Volume and Issue: 189, P. 114573 - 114573

Published: May 28, 2024

Language: Английский

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Improving geriatric outcomes through nutritional and immunonutritional strategies: Focus on surgical setting by a comprehensive evidence review

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102272 - 102272

Published: March 15, 2024

Language: Английский

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Exploring the medicinal significance of l-Arginine mediated nitric oxide in preventing health disorders

European Journal of Medicinal Chemistry Reports, Journal Year: 2024, Volume and Issue: 12, P. 100175 - 100175

Published: June 15, 2024

l-Arginine is an essential amino acid that plays a crucial role in various physiological processes. It serves as precursor for nitric oxide (NO), which has potent antioxidant and anti-inflammatory properties. This review aims to comprehensively examine the medicinal importance of l-arginine natural preventing human health disorders. A comprehensive literature search was conducted using PubMed, Google Scholar, other databases. Studies investigating effects its potential diseases were included. been shown mediate NO production with strong properties, scavenging free radicals reducing oxidative stress. demonstrated therapeutic mitigating conditions, including: Cardiovascular diseases, Neurodegenerative Metabolic disorders, Immune function Anti-aging effects. significant importance. Its ability scavenge radicals, improve endothelial function, support immune makes it promising agent treating wide range Further research warranted fully elucidate mechanisms action optimal dosage specific conditions.

Language: Английский

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Quercitrin improves cardiac remodeling following myocardial infarction by regulating macrophage polarization and metabolic reprogramming

Phytomedicine, Journal Year: 2024, Volume and Issue: 127, P. 155467 - 155467

Published: Feb. 19, 2024

The death and disability caused by myocardial infarction is a health problem that needs to be addressed worldwide, poor cardiac repair fibrosis after seriously affect patient recovery. Postmyocardial M2 macrophages of great significance for ventricular remodeling. Quercitrin (Que) common flavonoid in fruits vegetables has antioxidant, anti-inflammatory, antitumor other effects, but whether it role the treatment unclear. In this study, we constructed mouse model administered Que. We found through ultrasound Que administration improved ejection fraction reduced Staining heart sections detection marker protein levels revealed slowed infarction. Flow cytometry showed proportion was increased expression macrophage markers were Que-treated group. Finally, identified metabolomics reduces glycolysis, increases aerobic phosphorylation, alters arginine metabolic pathways, polarizing toward phenotype. Our research lays foundation future application cardiovascular diseases.

Language: Английский

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Beyond protein synthesis: the emerging role of arginine in poultry nutrition and host-microbe interactions

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 3, 2024

Arginine is a functional amino acid essential for various physiological processes in poultry. The dietary essentiality of arginine poultry stems from the absence enzyme carbamoyl phosphate synthase-I. specific requirement varies based on several factors, such as age, and status. Additionally, absorption utilization are also influenced by presence antagonists. However, interventions can mitigate effect these factors affecting utilization. In poultry, utilized four enzymes, namely, inducible nitric oxide synthase arginase, decarboxylase arginine: glycine amidinotransferase (AGAT). intermediates products metabolism enzymes mediate different functions most studied function humans, well its role immune response. exerts immunomodulatory primarily through metabolites (NO), ornithine, citrulline, polyamines, which take part inflammation or resolution inflammation. These properties potentiate use nutraceutical to prevent incidence enteric diseases Furthermore, gut microbiota, might have important implications microbial composition, regulation, metabolism, overall host health. This comprehensive review provides insights into multifaceted roles nutrition wellbeing, with particular emphasis potential regulation homeostasis

Language: Английский

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New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 28, 2024

Arginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage polarization immune activation. Specifically, interferon-gamma (IFN-γ) stimulates inducible nitric oxide synthase (iNOS) expression), leading to the conversion of arginine into citrulline (NO), while Interleukin-4 (IL4) promotes arginase activation, shifting metabolism toward ornithine. Concomitantly, IFN-γ triggers indoleamine 2,3-dioxygenase 1 (IDO1) induced (IL4i1), resulting kynurenine indole-3-pyruvic acid. These metabolic pathways tightly regulated by NAD + -dependent sirtuin proteins, with Sirt2 Sirt5 playing integral roles. In this review, we present novel insights that augment our understanding following Mycobacterium tuberculosis infection, particularly their relevance responses. Additionally, discuss methylation demethylation role regulating metabolism, potentially driving polarization.

Language: Английский

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Polyamines: the pivotal amines in influencing the tumor microenvironment

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 18, 2024

Abstract Cellular proliferation, function and survival is reliant upon maintaining appropriate intracellular polyamine levels. Due to increased metabolic needs, cancer cells elevate their pools through coordinated metabolism uptake. High levels of polyamines have been linked more immunosuppressive tumor microenvironments (TME) as support the growth many cell types such MDSCs, macrophages regulatory T-cells. As other pro-tumorigenic are highly dependent on for survival, pharmacological modulation a promising therapeutic strategy. This review covers roles in various TME including both immune stromal cells, well how competition nutrients, namely precursors, influences cellular landscape TME. It also details use biomarkers ways which depletion can increase immunogenicity reprogram tumors become responsive immunotherapy.

Language: Английский

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The flow cytometric analysis of depression focusing on modern-type depression and hikikomori: Exploring the link between subtypes of depression and immunological imbalances

Dialogues in Clinical Neuroscience, Journal Year: 2025, Volume and Issue: 27(1), P. 13 - 25

Published: Jan. 20, 2025

Introduction Depression includes different phenotypes. Modern-type depression (MTD) is a gateway disorder to pathological social withdrawal, known as hikikomori. Adverse childhood experiences (ACEs) are also important aetiologies of depression. Recently, immune imbalance has been proposed biological basis We hypothesised that peripheral immunological characteristics may be involved in subtyping

Language: Английский

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Aqueous humor metabolomic profiling identifies a distinct signature in pseudoexfoliation syndrome

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 23, 2025

Purpose PEXS was first described in 1917, yet its etiology still needs clarification. An imbalance between oxidants and antioxidants plays a significant role. leads to various ocular complications, including increased risk during cataract surgery due weak zonules, lens dislocation, reduced visual outcomes. Our study investigates whether metabolomics can provide insights into this pathology. Methods The included 183 patients undergoing at Pauls Stradins Clinical University Hospital. 104 did not have PEXS, while 79 were diagnosed with the condition. Intraocular fluid samples from these analyzed using targeted metabolite analysis, performed through HILIC liquid chromatography coupled mass spectrometry detection. Results aqueous humor of contains statistically higher levels cystine ( p < 0.001), citrulline phenylalanine = 0.041), tyrosine 0.025), serine 0.030), arginine 0.017), lactic acid 0.055), tryptophan creatinine 0.022). These results suggest potential link ferroptosis. Conclusion Ferroptosis is form programmed cell death characterized by iron-dependent LPO. inhibition antiporter system X c − oxidative stress, suggesting that changes seen could be linked findings indicate cysteine synthesis occurs via transsulfation pathway, attributable inhibiting . Treatment pseudoexfoliation should lower stress inside anterior chamber reducing uptake PUFAs, iron levels, supplementation.

Language: Английский

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